Funding sources This study was funded by private donations.
Q10-triggered facial vitiligo
Version of Record online: 2 DEC 2013
© 2013 British Association of Dermatologists
British Journal of Dermatology
Volume 169, Issue 6, pages 1333–1336, December 2013
How to Cite
Schallreuter, K.U. (2013), Q10-triggered facial vitiligo. British Journal of Dermatology, 169: 1333–1336. doi: 10.1111/bjd.12587
Conflicts of interest None declared.
- Issue online: 2 DEC 2013
- Version of Record online: 2 DEC 2013
- Accepted manuscript online: 17 AUG 2013 08:09AM EST
- Manuscript Accepted: 8 AUG 2013
Generation and accumulation of reactive oxygen/nitrogen species in the epidermis of patients with vitiligo has been widely documented. Moreover, semiquinone radical-mediated sensitivity has been shown in blood lymphocytes of these patients.
To determine the possible mechanism behind Q10-induced facial vitiligo.
This was a clinical assessment supported by in vivo Fourier transform–Raman spectroscopy and repigmentation.
Topical Q10 application generated hydrogen peroxide (H2O2) leading in turn to facial vitiligo in susceptible individuals. Proof of the basic result stemmed from reduction of epidermal H2O2 by using narrowband ultraviolet B-activated propseudocatalase PC-KUS in association with cessation of depigmentation and repigmentation of the lost skin colour.
Over-the-counter availability of Q10-containing topical formulations can be harmful to individuals susceptible to vitiligo.