British Journal of Dermatology

Cover image for Vol. 168 Issue 5

May 2013

Volume 168, Issue 5

Pages i–i, 923–1147

  1. Editor's Choice

    1. Top of page
    2. Editor's Choice
    3. Editorial
    4. Commentaries
    5. Review articles
    6. Systematic Review
    7. Cutaneous biology
    8. Original articles
    9. Correspondence
    10. News and Notices
    1. You have free access to this content
  2. Editorial

    1. Top of page
    2. Editor's Choice
    3. Editorial
    4. Commentaries
    5. Review articles
    6. Systematic Review
    7. Cutaneous biology
    8. Original articles
    9. Correspondence
    10. News and Notices
  3. Commentaries

    1. Top of page
    2. Editor's Choice
    3. Editorial
    4. Commentaries
    5. Review articles
    6. Systematic Review
    7. Cutaneous biology
    8. Original articles
    9. Correspondence
    10. News and Notices
    1. You have free access to this content
  4. Review articles

    1. Top of page
    2. Editor's Choice
    3. Editorial
    4. Commentaries
    5. Review articles
    6. Systematic Review
    7. Cutaneous biology
    8. Original articles
    9. Correspondence
    10. News and Notices
    1. Outdoor workers’ sun-related knowledge, attitudes and protective behaviours: a systematic review of cross-sectional and interventional studies (pages 928–940)

      D. Reinau, M. Weiss, C.R. Meier, T.L. Diepgen and C. Surber

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12160

      What’s already known about this topic?

      • • 
        Solar ultraviolet radiation (UVR) plays a key role in the aetiology of skin cancer.
      • • 
        Occupational UVR-exposure limits are greatly exceeded in various typical outdoor occupations.
      • • 
        Outdoor workers are at increased risk of developing nonmelanocytic skin cancers compared with indoor workers.

      What does this study add?

      • • 
        Outdoor workers’ sun-protective behaviours are largely inadequate and sunburn rates are high.
      • • 
        Sun-safety education in outdoor occupational settings has proven effective in fostering outdoor workers’ sun-protection habits.
    2. Pulsed dye laser-resistant port-wine stains: mechanisms of resistance and implications for treatment (pages 941–953)

      J.A. Savas, J.A. Ledon, K. Franca, A. Chacon and K. Nouri

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12204

      What’s already known about this topic?

      •  Port-wine stains (PWS) are common congenital vascular malformations for which patients often seek treatment.
      •  Although pulsed dye laser (PDL) is considered first-line for the treatment of PWS, a substantial number of lesions reach a treatment plateau and some fail to lighten at all.
      •  These PDL-resistant PWS require special consideration.

      What does this study add?

      •  This is a comprehensive review of alternative treatments and novel approaches for PDL-resistant PWS.
      •  Evidence-based knowledge is provided to help guide management decisions made by physicians faced with recalcitrant PWS.
  5. Systematic Review

    1. Top of page
    2. Editor's Choice
    3. Editorial
    4. Commentaries
    5. Review articles
    6. Systematic Review
    7. Cutaneous biology
    8. Original articles
    9. Correspondence
    10. News and Notices
    1. You have free access to this content
      Topical therapies for the treatment of plaque psoriasis: systematic review and network meta-analyses (pages 954–967)

      E.J. Samarasekera, L. Sawyer, D. Wonderling, R. Tucker and C.H. Smith

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12276

      What's already known about this topic?

      • Topical treatments are widely available and prescribed for plaque-type psoriasis.

      What does this study add?

      • Explicit rank order of efficacy, showing that treatment strategies containing potent or very potent corticosteroids are the most effective.
      • Investigator and patient evaluation of efficacy may differ.
      • Twice-daily application of the same intervention offers no important benefit over once-daily application for most treatments.
  6. Cutaneous biology

    1. Top of page
    2. Editor's Choice
    3. Editorial
    4. Commentaries
    5. Review articles
    6. Systematic Review
    7. Cutaneous biology
    8. Original articles
    9. Correspondence
    10. News and Notices
    1. The chromene sargachromanol E inhibits ultraviolet A-induced ageing of skin in human dermal fibroblasts (pages 968–976)

      J.-A. Kim, B.-N. Ahn, C.-S. Kong and S.-K. Kim

      Article first published online: 2 APR 2013 | DOI: 10.1111/bjd.12187

      What’s already known about this topic?

      •  Sargachromanol E isolated from Sargassum horneri prevents photoageing of skin.
      •  Skin photoageing can result from extrinsic factors such as ultraviolet (UV)A, which weakens collagen fibres.

      What does this study add?

      •  Photoageing studies indicate that UVA-induced expression of matrix metalloproteinases is associated with matrix degradation in dermal fibroblasts.
      • Sargassum horneri is a valuable source for the isolation of skin-protective chemicals.
  7. Original articles

    1. Top of page
    2. Editor's Choice
    3. Editorial
    4. Commentaries
    5. Review articles
    6. Systematic Review
    7. Cutaneous biology
    8. Original articles
    9. Correspondence
    10. News and Notices
    1. Clinical and laboratory investigations

      Serum IgA reactivity against GroEL of Streptococcus sanguinis and human heterogeneous nuclear ribonucleoprotein A2/B1 in patients with Behçet disease (pages 977–983)

      S.B. Cho, Z. Zheng, K.J. Ahn, M.J. Choi, S. Cho, D.-Y. Kim, H.S. Lee and D. Bang

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12128

      What’s already known about this topic?

      •  Infectious agents, especially Streptococcus sanguinis and herpes simplex virus, have long been postulated as major triggering factors for Behçet disease (BD).
      •  Human heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 has been identified as a target antigen of the antiendothelial-cell IgA antibody in patients with BD.

      What does this study add?

      •  Chaperonin GroEL was identified as a target antigen of the antiendothelial-cell IgA antibody in patients with BD.
      •  Serum IgA reactivities against recombinant S. sanguinis GroEL and human hnRNP A2/B1 were significantly correlated.
      •  Among the eight distinctive epitopes with significant homology between S. sanguinis GroEL and human hnRNP A2/B1, serum IgA reactivity of patients with BD was particularly strong with epitopes 3 and 6.
    2. Oxidative stress and psoriasis: the effect of antitumour necrosis factor-α inhibitor treatment (pages 984–989)

      T. Bacchetti, A. Campanati, G. Ferretti, O. Simonetti, G. Liberati and A.M. Offidani

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12144

      What’s already known about this topic?

      •  Psoriasis is associated with inflammation and an increase in the levels of biochemical markers of lipid peroxidation.

      What does this study add?

      •  Etanercept exerts a protective effect against lipid peroxidation and improves high-density lipoprotein antioxidant and anti-inflammatory properties .
    3. Ustekinumab improves psoriasis-related gene expression in noninvolved psoriatic skin without inhibition of the antimicrobial response (pages 990–998)

      E.M. Baerveldt, A.J. Onderdijk, D. Kurek, M. Kant, E.F. Florencia, A.S. Ijpma, P.J. van der Spek, J. Bastiaans, P.A. Jansen, J.W.J. van Kilsdonk, J.D. Laman and E.P. Prens

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12175

      What’s already known about this topic?

      •  Ustekinumab is an effective biologic for psoriasis.
      •  Psoriasis-related gene expression levels in noninvolved psoriatic skin are elevated compared with healthy skin.

      What does this study add?

      •  Ustekinumab improves psoriasis-related gene expression in noninvolved psoriatic skin.
      •  Ustekinumab alters expression of inflammation-related proteins in serum.
      •  Induction of antimicrobial peptides by tape-stripping is not inhibited by ustekinumab.
      •  A weakness in our study is the limited number of patients studied; however, there are consistent results.
    4. Ulcer recurrence after in-hospital treatment for recalcitrant venous leg ulceration (pages 999–1002)

      S. Reeder, K.-P. de Roos, M. de Maeseneer, A. Sommer and H.A.M. Neumann

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12164

      What’s already known about this topic?

      • • 
        About 8% of venous leg ulcers show nonhealing tendency.
      • • 
        The recurrence rate of venous leg ulcers is up to 40%.

      What does this study add?

      • • 
        After hospital admission because of recalcitrant venous leg ulcer the recurrence rate is almost 100%.
      • • 
        With regard to ulcer recurrence, there is no difference between underlying primary and secondary (post-thrombotic) venous insufficiency.
    5. Provoking factors, including chemicals, in Dutch patients with vitiligo (pages 1003–1011)

      C. Vrijman, D. Hosseinpour, J.G. Bakker, A. Wolkerstorfer, J.D. Bos, J.P.W. van der Veen and R.M. Luiten

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12162

      What’s already known about this topic?

      • • 
        Few epidemiological studies are available on factors provoking vitiligo in patients, and European data on chemically induced vitiligo are lacking.

      What does this study add?

      • • 
        This study gives an insight into patient-reported factors provoking vitiligo in a Dutch population, with a focus on chemicals (contact vitiligo).
    6. Evaluating the use of the interferon-γ response to Mycobacterium tuberculosis-specific antigens in patients with psoriasis prior to antitumour necrosis factor-α therapy: a prospective head-to-head cross-sectional study (pages 1012–1018)

      C.L. Martyn-Simmons, J.B. Mee, B.W. Kirkham, R.W. Groves and H.J. Milburn

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12176

      What’s already known about this topic?

      •  Reactivation of latent tuberculosis infection (LTBI) is a significant risk of antitumour necrosis factor therapy.
      •  The tuberculin skin test (TST) has been the standard diagnostic tool for LTBI but has its limitations, especially in the immunocompromised individual.
      •  As an alternative to the TST, in vitro interferon-γ-release assays (IGRA) are used; however, there are limited head-to-head studies and very little data on their use in the immunocompromised patient.

      What does this study add?

      •  Our study adds to the currently limited data on the use of IGRA in immunocompromised patients.
      •  Our study indicates that in certain situations a combination of TST and both IGRA tests may provide the optimal diagnostic yield.
    7. Induction of senescence pathways in Kindler syndrome primary keratinocytes (pages 1019–1026)

      E. Piccinni, G. Di Zenzo, R. Maurelli, E. Dellambra, M. Teson, C. Has, G. Zambruno and D. Castiglia

      Article first published online: 2 APR 2013 | DOI: 10.1111/bjd.12184

      What’s already known about this topic?

      •  Kindler syndrome (KS) is a genodermatosis caused by mutations in the FERMT1/KIND1 gene encoding kindlin-1.
      •  A clinically diagnostic feature of KS is premature skin ageing.
      •  Kindlin-1 deficiency associates with functional abnormalities of keratinocytes.
      •  Epidermal atrophy is thought to reflect a reduced proliferation rate of KS keratinocytes both in vivo and in vitro.

      What does this study add?

      •  KS primary keratinocyte cultures are depleted in stem cells, due to premature senescence.
      •  The reduced clonogenicity of KS keratinocytes correlates with both upregulation of proteins associated with cell senescence and downregulation of markers identifying stem cells.
      •  Our findings underline the crucial contribution of kindlin-1 deficiency in the premature ageing of primary human keratinocytes.
    8. Small-diameter melanocytic lesions: morphological analysis by means of in vivo confocal microscopy (pages 1027–1033)

      G. Pupelli, C. Longo, L. Veneziano, A.M. Cesinaro, G. Ferrara, S. Piana, E. Moscarella, C. Ricci, I. Zalaudek, S. Seidenari, G. Argenziano and G. Pellacani

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12212

      What’s already known about this topic?

      •  Small melanomas represent diagnostic pitfalls under clinical, dermoscopic and histopathological examination.
      •  Confocal microscopy is a new imaging tool that provides in vivo histopathological analysis of the skin.

      What does this study add?

      •  Our study highlights the role of confocal microscopy in diagnosing small melanomas and in differentiating them from naevi.
      •  The former display cytological atypia and irregular nesting, whereas the latter are typified by a more regular architecture and, occasionally, mild cytological atypia.
    9. Preliminary findings suggest hidradenitis suppurativa may be due to defective follicular support (pages 1034–1039)

      F.W. Danby, G.B.E. Jemec, W.Ch. Marsch and M. von Laffert

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12233

      What’s already known about this topic?

      •  The inflammation that destroys the folliculopilosebaceous unit (FPSU) in hidradenitis suppurativa (HS), or acne inversa, appears to start in the follicular portion of the unit.
      •  Recent work demonstrates (i) a psoriasiform pattern in the interfollicular epidermis, (ii) inflammatory activity concentrated in the perifollicular area, (iii) loss of volume and disappearance of sebaceous glands, and (iv) invasive sinus tracts, apparently the product of stem cells originating from the follicular bulge area.

      What does this study add?

      •  The periodic acid–Schiff (PAS)-positive equivalent of the basement membrane zone that invests the FPSU is missing, wispy or fragmented in patients with HS, particularly near the sebofollicular junction in early, border and centre lesions of HS compared with control skin.
      •  In contrast, the PAS positivity is strong and homogeneous at the dermoepidermal junction, and surrounding both the apocrine and eccrine glands and ducts in the dermis of patients with HS, irrespective of adjacent inflammation.
    10. Dermatological surgery and lasers

      Side-by-side comparison of photodynamic therapy and pulsed-dye laser treatment of port-wine stain birthmarks (pages 1040–1046)

      K. Gao, Z. Huang, K.-H. Yuan, B. Zhang and Z.-Q. Hu

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12130

      What’s already known about this topic?

      •  To date, several Chinese studies of photodynamic therapy (PDT) for port-wine stains (PWS) indicate that this therapeutic modality is effective and safe for the treatment of PWS of all colour and in all ages.
      •  Our retrospective study suggested that PDT is as effective as pulsed-dye laser (PDL) treatment for pink PWS and more effective than PDL for purple PWS.

      What does this study add?

      •  This is the first side-by-side and quantitative comparison of PDL and PDT.
      •  The findings reported here confirm that PDT is at least as effective and safe as PDL, if not superior to, for the treatment of red and purple flat PWS.
    11. Epidemiology and health services research

      Skin tumours in the West of Scotland renal transplant population (pages 1047–1053)

      L.J. Mackintosh, C.C. Geddes and R.M. Herd

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12129

      What’s already known about this topic?

      •  Renal transplant recipients are known to have an increased risk of malignancy, and the highest risks are for skin cancers.
      •  The rise in skin cancer is exponential for squamous cell carcinomas (SCCs) and linear for basal cell carcinomas (BCCs), leading to a reversal of the BCC:SCC ratio.

      What does this study add?

      •  This the first study of skin cancer in Scottish renal transplant recipients.
      •  An increased incidence of skin cancer was found, with a reduction but no reversal of the SCC:BCC ratio.
      •  A significant reduction in the duration of immunosuppression before development of a first skin cancer was observed following the introduction of ciclosporin in 1985, and when comparing triple vs. dual immunosuppression regimens.
    12. Dermatomyositis is associated with an increased risk of cardiovascular and cerebrovascular events: a Taiwanese population-based longitudinal follow-up study (pages 1054–1059)

      Y.-T. Lai, Y.-S. Dai, M.-F. Yen, L.-S. Chen, H.-H. Chen, R.G. Cooper and S.-L. Pan

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12245

      What’s already known about this topic?

      •  Connective-tissue disorders, such as rheumatoid arthritis, Sjögren syndrome, systemic lupus erythematosus and primary vasculitis have been linked to an increased risk of cardiovascular disease.
      •  Data on any association between dermatomyositis and cardiovascular or cerebrovascular disease is sparse.

      What does this study add?

      •  This population-based, age- and sex-matched longitudinal follow-up study shows that dermatomyositis is associated with increased risks of acute myocardial infarction and ischaemic stroke.
    13. Genetics

      Investigation of 20 non-HLA (human leucocyte antigen) psoriasis susceptibility loci in Chinese patients with psoriatic arthritis and psoriasis vulgaris (pages 1060–1065)

      Q. Yang, H. Liu, L. Qu, X. Fu, Y. Yu, G. Yu, H. Tian, Y. Yu, D. Sun, J. Peng, F. Bao, C. Yuan, N. Lu, J. Li, Y. Zhang and F. Zhang

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12142

      What’s already known about this topic?

      •  Recent genome-wide association studies have identified a number of novel psoriasis genetic susceptibility loci, but data on their association with psoriatic arthritis (PsA) are lacking.

      What does this study add?

      •  In this study, we provided, to our knowledge previously unreported, significant evidence for the involvement of ERAP1, IL28RA, GJB2 and PTTG1 loci in PsA susceptibility and confirmed the previously reported association with PsA and psoriasis vulgaris (PsV) in a Chinese population.
    14. Paediatric dermatology

      Juvenile spring eruption: an outbreak report and systematic review of the literature (pages 1066–1072)

      S.A.G. Lava, G.D. Simonetti, M. Ragazzi, S. Guarino Gubler and M.G. Bianchetti

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12197

      What’s already known about this topic?

      •  Juvenile spring eruption is a self-limiting photodermatosis.
      •  It appears on the light-exposed skin of the ears, usually in boys and young men in early spring after sunlight exposure during cold weather.
      •  The clinical picture is characteristic and easy recognizable.
      •  No review of the literature has been published so far.

      What does this study add?

      •  The condition is quite common and tends to occur in small outbreaks.
      •  Lack of hair cover and protuberant ears predispose to the condition.
      •  The condition tends to recur each spring.
    15. Photobiology

      Determinants of personal ultraviolet-radiation exposure doses on a sun holiday (pages 1073–1079)

      B. Petersen, E. Thieden, P.A. Philipsen, J. Heydenreich, H.C. Wulf and A.R. Young

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12211

      What’s already known about this topic?

      •  Exposure to solar ultraviolet radiation (UVR) is known to cause skin cancer.
      •  Based on questionnaires, studies have shown a correlation between intermittent solar UVR exposure and malignant melanoma.

      What does this study add?

      •  By on-site investigations on a sun holiday with measurements of personal doses of UVR and diary data, we showed significant correlations between behaviour and personal UVR exposure doses.
      •  The annual UVR dose of a Danish indoor worker is increased considerably by a sun holiday.
    16. Therapeutics

      A 24-week randomized clinical trial investigating the efficacy and safety of two doses of etanercept in nail psoriasis (pages 1080–1087)

      J.P. Ortonne, C. Paul, E. Berardesca, V. Marino, G. Gallo, Y. Brault and J.M. Germain

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12060

      What’s already known about this topic?

      •  Nail psoriasis can be painful and severely debilitating.
      •  Current treatments of nail psoriasis are limited.
      •  Very few studies have specifically investigated the efficacy and safety of systemic antipsoriatic agents in nail psoriasis.

      What does this study add?

      •  This is the first randomized study specifically designed to investigate the effects of etanercept on nail psoriasis in patients with moderate-to-severe psoriasis.
      •  The results of this study show nail psoriasis can be treated effectively with both treatment regimens of 50 mg etanercept twice weekly for 12 weeks followed by once weekly for 12 weeks and 50 mg etanercept once weekly for 24 weeks.
    17. The clinical and histological effect of home-use, combination blue–red LED phototherapy for mild-to-moderate acne vulgaris in Korean patients: a double-blind, randomized controlled trial (pages 1088–1094)

      H.H. Kwon, J.B. Lee, J.Y. Yoon, S.Y. Park, H.H. Ryu, B.M. Park, Y.J. Kim and D.H. Suh

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12186

      What’s already known about this topic?

      •  Standard acne treatments have demonstrated modest efficacy, but they may cause various side-effects and discomforts.
      •  It has been reported that the beneficial effects of blue and red light on acne result from different, distinct mechanisms. However, there has been no double-blind, randomized study for phototherapy with a combination of blue and red light-emitting diodes (LEDs).
      •  Previous clinical research has rarely elucidated the molecular interactions between visible light and active acne lesions.

      What does this study add?

      •  A 12-week, double-blind, randomized sham-device-controlled study demonstrated that home-use combination phototherapy with blue and red LEDs was quite effective for safely treating not only inflammatory, but also noninflammatory acne lesions.
      •  Sebum output and the average size of the sebaceous gland decreased, and the histopathological findings correlated well with clinical results, partly elucidating the associated molecular mechanisms.
      •  This novel phototherapy appears to be safe and effective for the treatment of acne.
    18. You have free access to this content
      Topical therapies for the treatment of localized plaque psoriasis in primary care: a cost-effectiveness analysis (pages 1095–1105)

      L. Sawyer, E.J. Samarasekera, D. Wonderling and C.H. Smith

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12261

      What's already known about this topic?

      • Topical therapies are the foundation of psoriasis treatment.
      • Combining agents in a single product or through concurrent application improves response. Frequency of application and potency also affect treatment efficacy.
      • Acquisition costs of topical agents vary substantially, and their relative value for money is uncertain.

      What does this study add?

      • This study provides the most complete economic evaluation of topical therapies licensed for the treatment of psoriasis of the trunk, limbs and scalp.
    19. Concise communications

      Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients (pages 1106–1108)

      T. Lepre, R. Cascella, M. Ragazzo, E. Galli, G. Novelli and E. Giardina

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12178

    20. Unexpected extradermatological findings in 31 patients with xeroderma pigmentosum type C (pages 1109–1113)

      S. Hadj-Rabia, D. Oriot, N. Soufir, H. Dufresne, E. Bourrat, S. Mallet, N. Poulhalon, E. Ezzedine, B. Grandchamp, A. Taïeb, B. Catteau, A. Sarasin and C. Bodemer

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12183

      What’s already known about this topic?

      •  Xeroderma pigmentosum type C (XP-C) is a rare, autosomal, recessive and cancer-prone disorder.
      •  Basal cell carcinomas and squamous cell carcinomas are frequent.
      •  Care is based on ocular and cutaneous photoprotection.

      What does this study add?

      •  A large, homogeneous series of genetically proven patients with XP-C has been studied.
      •  Multinodular thyroid have been found, along with a risk of early adenocarcinoma, neurological involvement and unexplained relatively short stature, with height-for-weight z-scores below −1 SD.
      Corrected by:

      Corrigenda: Corrigenda

      Vol. 169, Issue 3, 726, Article first published online: 30 AUG 2013

    21. Long-term efficacy of single-dose radiofrequency-induced heat therapy vs. intralesional antimonials for cutaneous leishmaniasis in India (pages 1114–1119)

      R.A. Bumb, N. Prasad, K. Khandelwal, N. Aara, R.D. Mehta, B.C. Ghiya, P. Salotra, L. Wei, S. Peters and A.R. Satoskar

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12205

      What’s already known about the topic?

      •  Radiofrequency-induced heat therapy (RFHT) is an alternative to antimonials for the treatment of cutaneous leishmaniasis (CL). However, long-term efficacy of RFHT is not clear.

      What does this study add?

      •  This study demonstrates that RFHT is safe, cosmetically acceptable and effective in inducing a long-term cure of CL.
    22. Assessment of ultraviolet-radiation-induced DNA damage within melanocytes in skin of different constitutive pigmentation (pages 1120–1123)

      S. Del Bino, J. Sok and F. Bernerd

      Article first published online: 2 APR 2013 | DOI: 10.1111/bjd.12201

      What’s already known about this topic?

      •  The amount of melanin in skin inversely correlates with the risk of skin cancer, including melanoma.
      •  Specific data on the impact of ultraviolet radiation (UVR) on melanocytes in skin of different constitutive pigmentation are rare.

      What does this study add?

      •  This study yields new insights into the relationship between the level of constitutive pigmentation and UVR-induced DNA damage within melanocytes, explaining the susceptibility of certain skin types to melanoma or pigmentary disorders.
    23. Ustekinumab does not increase body mass index in patients with chronic plaque psoriasis: a prospective cohort study (pages 1124–1127)

      P. Gisondi, A. Conti, G. Galdo, S. Piaserico, C. De Simone and G. Girolomoni

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12235

      What’s already known about this topic?

      •  Chronic plaque psoriasis is frequently associated with obesity.
      •  Antitumour necrosis factor α treatments can induce body-weight increase in patients with psoriasis, whereas the effect of ustekinumab on body weight is not known.

      What does this study add?

      •  Patients with psoriasis treated with ustekinumab do not have changes in body mass index after 7 months of treatment, whereas those receiving infliximab manifest this effect.
  8. Correspondence

    1. Top of page
    2. Editor's Choice
    3. Editorial
    4. Commentaries
    5. Review articles
    6. Systematic Review
    7. Cutaneous biology
    8. Original articles
    9. Correspondence
    10. News and Notices
    1. Screening for second primary melanomas: is it efficient? (pages 1133–1135)

      S.M.E. Geurts, J.A.A.M. van Dijck, J.J. Bonenkamp, P.M.M.B. Soetekouw and A.L.M. Verbeek

      Article first published online: 25 APR 2013 | DOI: 10.1111/bjd.12138

  9. News and Notices

    1. Top of page
    2. Editor's Choice
    3. Editorial
    4. Commentaries
    5. Review articles
    6. Systematic Review
    7. Cutaneous biology
    8. Original articles
    9. Correspondence
    10. News and Notices

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