The role of mitochondrial function and cellular bioenergetics in ageing and disease (pages 1–8)
M.D. Brand, A.L. Orr, I.V. Perevoshchikova and C.L. Quinlan
Article first published online: 21 JUN 2013 | DOI: 10.1111/bjd.12208
What’s already known about this topic?
Mitochondrial dysfunction is widely implicated in ageing and its diseases.
Mitochondria are well understood; one paper in every 154 indexed in PubMed since 1998 has studied mitochondrial function.
Nonetheless, the mechanisms and regulation of mitochondrial reactive oxygen species (ROS) formation remain poorly described.
What does this study add?