British Journal of Dermatology

Cover image for Vol. 169 Issue s2

Special Issue: ASDS Cellular Bioenergetics Revolution Proceedings. Guest Editors: Maritza I. Perez and Mary B. Johnson. Publication of this supplement was supported by Procter & Gamble.

July 2013

Volume 169, Issue Supplement s2

Pages 1–44

  1. ASDS Cellular Bioenergetics Revolution Proceedings. Guest Editors: Maritza I. Perez and Mary B. Johnson. Publication of this supplement was supported by Procter & Gamble.

    1. Top of page
    2. ASDS Cellular Bioenergetics Revolution Proceedings. Guest Editors: Maritza I. Perez and Mary B. Johnson. Publication of this supplement was supported by Procter & Gamble.
    1. Original Articles

      The role of mitochondrial function and cellular bioenergetics in ageing and disease (pages 1–8)

      M.D. Brand, A.L. Orr, I.V. Perevoshchikova and C.L. Quinlan

      Article first published online: 21 JUN 2013 | DOI: 10.1111/bjd.12208

      What’s already known about this topic?

      •  Mitochondrial dysfunction is widely implicated in ageing and its diseases.
      •  Mitochondria are well understood; one paper in every 154 indexed in PubMed since 1998 has studied mitochondrial function.
      •  Nonetheless, the mechanisms and regulation of mitochondrial reactive oxygen species (ROS) formation remain poorly described.

      What does this study add?

      •  The capacities and in vitro rates of different sites of mitochondrial ROS production are being established.
      •  The techniques involved are applicable to isolated cells.
    2. Mitochondrial DNA damage as a biomarker for ultraviolet radiation exposure and oxidative stress (pages 9–14)

      M.A. Birch-Machin, E.V. Russell and J.A. Latimer

      Article first published online: 21 JUN 2013 | DOI: 10.1111/bjd.12207

      What’s already known about this topic?

      •  For a number of years, mitochondrial DNA (mtDNA) damage has been identified in many diseases and ageing in many tissues. Relatively recently it been used as a sensitive and reliable biomarker of ultraviolet radiation (UVR) exposure in human skin.
      •  This is a relatively new field compared with the effects of UVR on nuclear genetic damage in skin.

      What does this study add?

      •  This review provides an update of the types of mtDNA damage associated with increasing UVR exposure and ageing as well as the effects on oxidative stress by UVR and infrared radiation.
      •  Provides potential areas of application for this technology.

SEARCH

SEARCH BY CITATION