Treatment of port wine stains with pulsed dye laser and topical timolol: a multicenter randomized controlled trial (pages 1350–1353)
T. Passeron, A. Maza, E. Fontas, G. Toubel, P. Vabres, C. Livideanu, J.-M. Mazer, B. Rossi, F. Boukari, Y. Harmelin, I. Dreyfus, J. Mazereeuw-Hautier and J.-P. Lacour
Version of Record online: 19 JUN 2014 | DOI: 10.1111/bjd.12772
What's already known about this topic?
- Neoangiogenesis occurs within days following laser treatment of port wine stains (PWS).
- The expression of vascular endothelial growth factor (VEGF) and its receptors has been shown to be increased in PWS lesions, and to play a key role in neoangiogenesis.
- By acting on VEGF, timolol gel might be useful for preventing post-laser angiogenesis.
What does this study add?
- Topical use of twice daily applications of timolol gel showed good tolerance, but failed to significantly improve the efficacy of pulsed dye laser treatment of PWS.