• Please log in or register to access this feature.

Correspondence

You have full text access to this OnlineOpen article

Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia

  1. Juan Sandoval1,†,
  2. Holger Heyn1,†,
  3. Jesús Méndez-González1,
  4. Antonio Gomez1,
  5. Sebastian Moran1,
  6. Montserrat Baiget2,
  7. Montserrat Melo3,
  8. Isabel Badell4,
  9. Josep F. Nomdedéu5,
  10. Manel Esteller1,6,7

Article first published online: 30 OCT 2012

DOI: 10.1111/bjh.12113

Issue

British Journal of Haematology

British Journal of Haematology

Volume 160, Issue 3, pages 406–409, February 2013

Additional Information

How to Cite

Sandoval, J., Heyn, H., Méndez-González, J., Gomez, A., Moran, S., Baiget, M., Melo, M., Badell, I., Nomdedéu, J. F. and Esteller, M. (2013), Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia. British Journal of Haematology, 160: 406–409. doi: 10.1111/bjh.12113

Author Information

  1. 1

    Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L Hospitalet de Llobregat, Barcelona, Catalonia, Spain

  2. 2

    Department of Genetics, Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain

  3. 3

    Department of Paediatrics, Hospital Parc Taulí de Sabadell, Barcelona, Catalonia, Spain

  4. 4

    Department of Paediatric Haematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain

  5. 5

    Department of Haematology, Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain

  6. 6

    Department of Physiological Sciences II, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain

  7. 7

    Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain

  1. †

    These authors contributed equally to this study

  1. †

    These authors contributed equally to this study

  2. Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms

Publication History

  1. Issue published online: 17 JAN 2013
  2. Article first published online: 30 OCT 2012
  3. Manuscript Accepted: 5 SEP 2012
  4. Manuscript Received: 6 JUL 2012

Funded by

  • Childhood Research Grant from the Asociación Española Contra el Cáncer (AECC)
  • Childhood Research Grant from the Asociación Española Contra el Cáncer (AECC)
  • European Community's Seventh Framework Programme. Grant Numbers: FP7/2007-2013, HEALTH-F5-2011-282510 – BLUEPRINT

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (670K)
FilenameFormatSizeDescription
bjh12113-sup-0001-FigS1-S3-TableS1-S3.pdfapplication/PDF1893K

Fig S1. DNA methylation level in different genomic features.

Fig S2. Differentially methylated CpG site (dmCpG) between B-cell (NBC) and B-ALL (ALL) samples.

Fig S3. Relative number of hyper- and hypomethylated differentially methylated sites between ALL-1 and ALL-2 considering their overlap with loci occupied by different histone marks, H2A.Z and CTCF.

Table S1. 3,414 differentially methylated CpG sites comparing healthy B-cells and B-ALL samples.

Table S2. 20,661differentially methylated CpG sites comparing B-cell group ALL-1 and ALL-2.

Table S3. Gene ontology analysis of hypomethylated gene promoters in group ALL-2.

Please note: Wiley-Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

View Full Article with Supporting Information (HTML) Get PDF (670K)