GB and KA contributed equally to this study.
Leucocytosis and thrombosis at diagnosis are associated with poor survival in polycythaemia vera: a population-based study of 327 patients
Version of Record online: 15 NOV 2012
© 2012 Blackwell Publishing Ltd
British Journal of Haematology
Volume 160, Issue 2, pages 251–254, January 2013
How to Cite
Bonicelli, G., Abdulkarim, K., Mounier, M., Johansson, P., Rossi, C., Jooste, V., Andreasson, B., Maynadié, M. and Girodon, F. (2013), Leucocytosis and thrombosis at diagnosis are associated with poor survival in polycythaemia vera: a population-based study of 327 patients. British Journal of Haematology, 160: 251–254. doi: 10.1111/bjh.12117
- Issue online: 10 JAN 2013
- Version of Record online: 15 NOV 2012
- Manuscript Accepted: 20 SEP 2012
- Manuscript Received: 29 JUN 2012
- Tulipes contre le cancer Châlon s/Saône to FG
- polycythaemia vera;
- risk factors;
Three hundred and twenty-seven patients from two population-based cohorts with an established diagnosis of polycythaemia vera were studied for prognostic risk factors for survival and leukaemia in a long-term survey. The relative survival (RS) was 72% and 46% at 10 and 20 years respectively, from the time of diagnosis. Multivariate analysis identified age >70 years, white blood cell count >13 × 109/l and thrombo-embolism at diagnosis as independent risk factors. Patients with two or three of these factors had a 10 year RS of 26%, compared with 59% and 84% in patients with one and no risk factors, respectively. Age and leucocyte count are the main predicting factors for survival in polycythaemia vera.