Research Paper
You have free access to this content
Combination of recombinant factor VIIa and fibrinogen corrects clot formation in primary immune thrombocytopenia at very low platelet counts
Article first published online: 15 NOV 2012
DOI: 10.1111/bjh.12118
© 2012 Blackwell Publishing Ltd
Additional Information
How to Cite
Larsen, O. H., Stentoft, J., Radia, D., Ingerslev, J. and Sørensen, B. (2013), Combination of recombinant factor VIIa and fibrinogen corrects clot formation in primary immune thrombocytopenia at very low platelet counts. British Journal of Haematology, 160: 228–236. doi: 10.1111/bjh.12118
Publication History
- Issue published online: 10 JAN 2013
- Article first published online: 15 NOV 2012
- Manuscript Accepted: 12 SEP 2012
- Manuscript Received: 19 APR 2012
Funded by
- Helga and Peter Korning's Foundation
- The A.P. Møller Foundation for the Advancement of Medical Sciences
- Aarhus University
References
- , , & (1986) Efficacy of platelet transfusions in immune thrombocytopenia. American Journal of Medicine, 80, 1051–1054.
- , , & (2007) Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count. Haematologica, 92, 694–697.
- , & (2009a) Fibrinogen concentrate – a potential universal hemostatic agent. Expert Opinion on Biological Therapy, 9, 1325–1333.
- , , & (2009b) Recombinant factor VIIa and fibrinogen display additive effect during in vitro haemodilution with crystalloids. Acta Anaesthesiologica Scandinavica, 53, 332–338.
- , , , , , & (2008) Monitoring recombinant factor VIIa treatment: efficacy depends on high levels of fibrinogen in a model of severe dilutional coagulopathy. Journal of Cardiothoracic and Vascular Anesthesia, 22, 675–680.
- , , , , , , & (2003) Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiology of Haemostasis and Thrombosis, 33, 4–15.
- , , , & (2009) The German Haemovigilance System – reports of serious adverse transfusion reactions between 1997 and 2007. Transfusion Medicine, 19, 340–349.
- , , , , & (2001) High-dose factor VIIa increases initial thrombin generation and mediates faster platelet activation in thrombocytopenia-like conditions in a cell-based model system. British Journal of Haematology, 114, 114–120.
- , , , , , , , , , & (1996) Clinical experience with recombinant factor VIIa in patients with thrombocytopenia. Haemostasis, 26 Suppl 1, 159–164.
- & (1977) Management of idiopathic thrombocytopenic purpura in the adult. Seminars in Thrombosis and Hemostasis, 3, 160–174.
- , , , , , & (2009) The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia. Anesthesia and Analgesia, 108, 751–758.
- , & (2007) Whole blood laboratory model of thrombocytopenia for use in evaluation of hemostatic interventions. Annals of Hematology, 86, 217–221.
- , , , , & (2009) Whole blood coagulation in children with thrombocytopenia and the response to platelet replacement, recombinant factor VIIa, and a potent factor VIIa analogue. British Journal of Haematology, 144, 99–106.
- , , , & (2010) Artificial contact pathway activation masks the haemostatic potential of rFVIIa and NN1731 in thrombocytopenic whole blood. British Journal of Haematology, 150, 124–127.
- , , , & (2011) Diagnostic performance and therapeutic consequence of thromboelastometry activated by kaolin versus a panel of specific reagents. Anesthesiology, 115, 294–302.
- , & (2009) rFVIIa and a new enhanced rFVIIa-analogue, NN1731, reduce bleeding in clopidogrel-treated and in thrombocytopenic rats. Journal of Thrombosis and Haemostasis, 7, 651–657.
- , , , , & (2005) Recombinant factor VIIa enhances platelet adhesion and activation under flow conditions at normal and reduced platelet count. Journal of Thrombosis and Haemostasis, 3, 742–751.
- & (2010) Recombinant factor VIIa: an assessment of evidence regarding its efficacy and safety in the off-label setting. Hematology American Society of Hematology Education Program Book, 2010, 153–159.
- & (2004) Clinical measurement of thrombin generation by calibrated automated thrombography requires contact factor inhibition. Journal of Thrombosis and Haemostasis, 2, 1954–1959.
- , , & (2007) Citrate anticoagulation and the dynamics of thrombin generation. Journal of Thrombosis and Haemostasis, 5, 2055–2061.
- , , , & (2011) Differential roles of fibrinogen and von Willebrand factor on clot formation and platelet adhesion in reconstituted and immune thrombocytopenia. Anesthesia and Analgesia, 112, 1034–1040.
- , , & (1997) Platelet activity of high-dose factor VIIa is independent of tissue factor. British Journal of Haematology, 99, 542–547.
- (2005) Fibrinogen and fibrin structure and functions. Journal of Thrombosis and Haemostasis, 3, 1894–1904.
- , , , , , , & (2011) Long-term clinical outcomes of patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study. Blood, 117, 3514–3520.
- , , , , , , & (2007) The immune thrombocytopenic purpura (ITP) bleeding score: assessment of bleeding in patients with ITP. British Journal of Haematology, 138, 245–248.
- , , , , , & (2005) Recombinant activated factor VII in treatment of bleeding complications following hematopoietic stem cell transplantation. Journal of Thrombosis and Haemostasis, 3, 1935–1944.
- , , , , , , , , , , , , , , , , , , , , & (2010) International consensus report on the investigation and management of primary immune thrombocytopenia. Blood, 115, 168–186.
- , , , & (1996) Blood clotting in minimally altered whole blood. Blood, 88, 3432–3445.
- , , , & (2008) Massive platelet transfusion is a rapidly effective emergency treatment in patients with refractory autoimmune thrombocytopenia. Thrombosis and Haemostasis, 100, 762–765.
- , , & (2009) Experiences with recombinant FVIIa in the emergency treatment of patients with autoimmune thrombocytopenia: a review of the literature. Annals of Hematology, 88, 11–15.
- , , , & (2003) Whole blood coagulation thrombelastographic profiles employing minimal tissue factor activation. Journal of Thrombosis and Haemostasis, 1, 551–558.
- , , & (2009) The combination of recombinant factor VIIa and fibrinogen correct clotting ex vivo in patient samples obtained following cardiopulmonary bypass surgery. Thrombosis Research, 124, 695–700.
- & (2008) Treatment of immune-mediated thrombocytopenia purpura with concurrent intravenous immunoglobulin and platelet transfusion: a retrospective review of 40 patients. American Journal of Hematology, 83, 122–125.
- , , , , , , & (2004) Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes. Transfusion, 44, 1143–1148.
- , , , & (2008) Improved clot formation by combined administration of activated factor VII (NovoSeven) and fibrinogen (Haemocomplettan P). Anesthesia and Analgesia, 106, 732–738.
- , , , , , , & (2006) Normal values for thrombelastography (ROTEM) and selected coagulation parameters in porcine blood. Thrombosis Research, 117, 597–602.
- , , , , , , , & (2007) The effect of fibrinogen concentrate on thrombocytopenia. Journal of Thrombosis and Haemostasis, 5, 1019–1025.

1365-2141/asset/olbannerleft.gif?v=1&s=2237887a0dba115836e329b1c5824f93749b814b)
1365-2141/asset/olbannerright.gif?v=1&s=01b5795d608a5571b530fcd8eb300f01b48de3b2)
