Single nucleotide polymorphisms and the risk of venous thrombosis: results from a Danish case-cohort study

Authors

  • Tarec C. El-Galaly,

    1. Department of Haematology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
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  • Marianne T. Severinsen,

    1. Department of Haematology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
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  • Kim Overvad,

    1. Department of Cardiology, Centre for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    2. Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark
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  • Rudi Steffensen,

    1. Department of Clinical Immunology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
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  • Anders K. Vistisen,

    1. Department of Haematology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
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  • Anne Tjønneland,

    1. Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
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  • Søren R. Kristensen

    Corresponding author
    1. Department of Clinical Biochemistry, Centre for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark
    • Correspondence: Søren Risom Kristensen, Department of Biochemistry, Aalborg Hospital, Aarhus University Hospital, Hobrovej 18-22, DK-9000 Aalborg, Denmark. E-mail: srk@rn.dk

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Summary

A number of single nucleotide polymorphisms (SNP) have been linked to higher risk of venous thromboembolism (VTE). We investigated the VTE risk associated with SNPs in the GP6 (rs1613662), SERPINC1 (rs2227589), F11 (rs2036914 and rs2289252), FGG (rs2066865), and F12 (rs1801020) genes. In F11, the CC genotype for rs2036914 and the CT and TT genotypes for rs2289252 were associated with a significantly higher VTE risk. A trend toward a thrombogenic effect was observed for the risk alleles of the GP6 and FGG SNPs. Risk estimates were unaffected by adjustments for blood type and F5 rs6025 (Factor V Leiden) mutation.

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