Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management


Correspondence: Julie A. Peterson, Ph.D., Blood Research Institute, BloodCenter of Wisconsin, 8727 Watertown Plank Rd, Milwaukee WI 53226-3548, US.



Neonatal alloimmune thrombocytopenia, (NAIT) is caused by maternal antibodies raised against alloantigens carried on fetal platelets. Although many cases are mild, NAIT is a significant cause of morbidity and mortality in newborns and is the most common cause of intracranial haemorrhage in full-term infants. In this report, we review the pathogenesis, clinical presentation, laboratory diagnosis and prenatal and post-natal management of NAIT and highlight areas of controversy that deserve the attention of clinical and laboratory investigators.