Primary peripheral T-cell lymphoma, not otherwise specified of the thyroid with autoimmune thyroiditis

Authors

  • Noriaki Yoshida,

    1. Division of Molecular Medicine, Aichi Cancer Centre Research Institute, Nagoya, Japan
    2. Department of Cancer Genetics, Nagoya University Graduate School of Medicine at Aichi Cancer Centre Research Institute, Nagoya, Japan
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  • Momoko Nishikori,

    1. Department of Haematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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  • Tohru Izumi,

    1. Departments of Haematology and Pathology, Tochigi Cancer Centre, Utsunomiya, Japan
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  • Yoshitaka Imaizumi,

    1. Haematology and Molecular Medicine Unit, Nagasaki University Graduate School of Biomedical Sciences, Atomic Bomb Disease Institute, Nagasaki, Japan
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  • Yasushi Sawayama,

    1. Haematology and Molecular Medicine Unit, Nagasaki University Graduate School of Biomedical Sciences, Atomic Bomb Disease Institute, Nagasaki, Japan
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  • Daisuke Niino,

    1. Department of Pathology, Kurume University School of Medicine, Kurume, Japan
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  • Masaharu Tashima,

    1. Department of Haematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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  • Sayuri Hoshi,

    1. Departments of Haematology and Pathology, Tochigi Cancer Centre, Utsunomiya, Japan
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  • Koichi Ohshima,

    1. Department of Pathology, Kurume University School of Medicine, Kurume, Japan
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    • These authors contributed equally.
  • Masanori Shimoyama,

    1. Multi-institutional Clinical Trial Support Centre, National Cancer Centre, Tokyo, Japan
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    • These authors contributed equally.
  • Masao Seto,

    Corresponding author
    1. Department of Cancer Genetics, Nagoya University Graduate School of Medicine at Aichi Cancer Centre Research Institute, Nagoya, Japan
    • Division of Molecular Medicine, Aichi Cancer Centre Research Institute, Nagoya, Japan
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    • These authors contributed equally.
  • Kunihiro Tsukasaki

    Corresponding author
    1. Haematology and Molecular Medicine Unit, Nagasaki University Graduate School of Biomedical Sciences, Atomic Bomb Disease Institute, Nagasaki, Japan
    2. Department of Haematology, National Cancer Centre Hospital East, Kashiwa, Japan
    • Division of Molecular Medicine, Aichi Cancer Centre Research Institute, Nagoya, Japan
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    • These authors contributed equally.

Correspondence: Masao Seto, Division of Molecular Medicine, Aichi Cancer Centre Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.

E-mail: mseto@aichi-cc.jp

and

Kunihiro Tsukasaki, Department of Haematology, National Cancer Centre Hospital East 6-5-1 Kashiwanoha, Kashiwa 277-8577, Japan.

E-mail: ktsukasa@east.ncc.go.jp

Summary

Primary peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) of the thyroid is an extremely rare neoplasm. Six cases of primary PTCL-NOS of the thyroid were analysed for clinicopathological features and genomic alteration patterns using oligo-array comparative genomic hybridization. All patients had a diffusely enlarged thyroid and three cases showed leukaemic manifestation. Five of the six cases had anti-thyroid antibodies and the remaining case showed hypothyroidism, suggesting that all cases had autoimmune thyroiditis. Except for one early relapsed case, the remaining five patients are alive and three of these five individuals have survived for 70 months or more. Interestingly, two cases showed spontaneous regressions after partial thyroid biopsy without any therapy. Leukaemic manifestation disappeared after irradiation of the thyroid mass in another two cases. The tumour cells were positive for CD3, CD4 and CXCR3 in all cases, suggesting that the tumour cells are of a type 1 helper T-cell origin. All six cases showed genomic alterations that were different from those previously reported for PTCL-NOS. The loss of 6q24·2 was characteristic and was detected in four of the six cases. These results suggest that primary PTCL-NOS of the thyroid arising from autoimmune thyroiditis is a distinct disease entity among heterogeneous PTCL-NOS.

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