These authors contributed equally to this work as first authors.
Improved risk stratification in myeloma using a microRNA-based classifier
Version of Record online: 30 MAY 2013
© 2013 John Wiley & Sons Ltd
British Journal of Haematology
Volume 162, Issue 3, pages 348–359, August 2013
How to Cite
Wu, P., Agnelli, L., Walker, B. A., Todoerti, K., Lionetti, M., Johnson, D. C., Kaiser, M., Mirabella, F., Wardell, C., Gregory, W. M., Davies, F. E., Brewer, D., Neri, A. and Morgan, G. J. (2013), Improved risk stratification in myeloma using a microRNA-based classifier. British Journal of Haematology, 162: 348–359. doi: 10.1111/bjh.12394
- Issue online: 11 JUL 2013
- Version of Record online: 30 MAY 2013
- Manuscript Accepted: 3 APR 2013
- Manuscript Received: 28 FEB 2013
Table SI. Demographic, serological and molecular features of the patients included in the miRNA expression analysis compared with those who entered into the overall trial.
Table SII. The specific deregulation of miRNAs in (A) 4p16, (B) MAF and (C) 11q13 subtypes compared to other subtypes (SAM, FDR < 0·05 based on 1000 permutations).
Table SIII. miRNAs associated with PFS (unadjusted P < 0·05).
Table SIV. Putative targets of miR-886-5p identified using the selection criteria described in methods (ranked by P values for correlation between miRNA and mRNA expression).
Fig S1. Coexpression between individual miRNAs within the same cluster or family.
Fig S2. Density plots showing expression pattern of miR-17, miR-18a and miR-886-5p across 163 samples and the thresholds for high and low expression.
Fig S3. Kaplan-Meier estimated curves of the groups defined by high/low expression levels of (A) miR-886-5p and (B) miR-17, which is consistent across both treatment pathways.
Fig S4. The three risk groups based on 2-miRNA-classifier remain significant on myeloma-specific survival, excluding the possibility that their association with OS is due to non-myeloma-related mortalities.
Fig S5. Kaplan-Meier estimated curves in Myeloma IX GEP set (N = 261) of the groups defined by the expression levels of the candidate target for miR-886-5p, NR3C1. Lower expression of NR3C1 (1st quartile) is associated with shorter OS.
Fig S6. Boxplot distribution showing the associations between expression levels of miR-17/miR-886-5p and cytogenetic subgroups (Wilcoxon test).
Fig S7. The correlation analyses of miRNA expression and their copy numbers show that the expression levels of miR-886-5p and miR-17 are not copy number sensitive.
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