Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study
Version of Record online: 2 MAY 2014
© 2014 John Wiley & Sons Ltd
British Journal of Haematology
Volume 166, Issue 4, pages 540–549, August 2014
How to Cite
Lucena-Araujo, A. R., Kim, H. T., Jacomo, R. H., Melo, R. A., Bittencourt, R., Pasquini, R., Pagnano, K., Fagundes, E. M., de Lourdes Chauffaille, M., Chiattone, C. S., Lima, A. S., Kwaan, H. C., Gallagher, R., Niemeyer, C. M., Schrier, S. L., Tallman, M. S., Grimwade, D., Ganser, A., Berliner, N., Ribeiro, R. C., Lo-Coco, F., Löwenberg, B., Sanz, M. A. and Rego, E. M. (2014), Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study. British Journal of Haematology, 166: 540–549. doi: 10.1111/bjh.12921
- Issue online: 25 JUL 2014
- Version of Record online: 2 MAY 2014
- Manuscript Accepted: 4 MAR 2014
- Manuscript Received: 28 DEC 2013
- Fundação de Amparo a Pesquisa do Estado de São Paulo
- FAPESP. Grant Numbers: #2013/08135-2, #2007/55067-1
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- CNpQ. Grant Number: #573754/2008-0
Data S1. Statistical analysis of the supplementary data.
Fig S1. Overall survival in APL patients divided into quartiles (Q) according to KMT2E/ABL1 expression.
Fig S2. Receiver operating characteristic (ROC) curve analysis to define the optimal cut-off point for KMT2E expression.
Fig S3. Overall survival in APL patients according to age (younger than 50 years vs. older than 50 years).
Table SI. Univariable and multivariable Cox analysis for complete remission, overall survival and disease-free survival according to KMT2E transcript levels (categorical variable).
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