Urological Oncology

A comparison of patient and tumour characteristics in two UK bladder cancer cohorts separated by 20 years

  1. Richard T. Bryan1,*,
  2. Maurice P. Zeegers2,3,
  3. Eline H. van Roekel2,
  4. Deborah Bird4,
  5. Margaret R. Grant5,
  6. Janet A. Dunn6,
  7. Sarah Bathers7,
  8. Gulnaz Iqbal6,
  9. Humera S. Khan7,
  10. Stuart I. Collins4,
  11. Andrew Howman4,
  12. Nayneeta S. Deshmukh8,
  13. Nicholas D. James1,8,
  14. Kar Keung Cheng2,
  15. D. Michael A. Wallace9

Article first published online: 4 MAR 2013

DOI: 10.1111/bju.12032

Additional Information

How to Cite

Bryan, R. T., Zeegers, M. P., van Roekel, E. H., Bird, D., Grant, M. R., Dunn, J. A., Bathers, S., Iqbal, G., Khan, H. S., Collins, S. I., Howman, A., Deshmukh, N. S., James, N. D., Cheng, K. K. and Wallace, D. M. A. (2013), A comparison of patient and tumour characteristics in two UK bladder cancer cohorts separated by 20 years. BJU International. doi: 10.1111/bju.12032

Author Information

  1. 1

    School of Cancer Sciences, University of Birmingham, Birmingham, UK

  2. 2

    Unit of Urologic and Genetic Epidemiology, Department of Public Health, Epidemiology and Biostatistics, School of Population Sciences, University of Birmingham, Birmingham, UK

  3. 3

    Department of Genetics and Cell Biology, Maastricht University Medical Centre, Maastricht, the Netherlands

  4. 4

    Cancer Research UK Clinical Trials Unit, School of Cancer Sciences, Birmingham, UK

  5. 5

    Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, UK

  6. 6

    Warwick Clinical Trials Unit, Warwick Medical School, The University of Warwick, Coventry, UK

  7. 7

    Primary Care Clinical Sciences, University of Birmingham, Birmingham, UK

  8. 8

    Department of Histopathology, University Hospitals Birmingham NHS Foundation Trust, The Queen Elizabeth Hospital, Birmingham, UK

  9. 9

    Surgery (Fremantle Hospital), The University of Western Australia (M509), Crawley, WA, Australia

* Correspondence: Richard T. Bryan, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
e-mail: r.t.bryan@bham.ac.uk.

Publication History

  1. Article first published online: 4 MAR 2013

Funded by

  • Cancer Research UK
  • University of Birmingham
  • Birmingham & The Black Country and West Midlands North and South Comprehensive Local Research Networks

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Keywords:

  • bladder cancer;
  • cohort;
  • epidemiology;
  • urothelial cancer

Objectives

  • To compare patient and tumour characteristics at presentation from two large bladder cancer cohorts, with recruitment separated by 15–20 years
  • To identify significant differences in the West Midlands' urothelial cancer of the bladder (UCB) population during this period.

Patients and Methods

  • Data were collected prospectively from 1478 patients newly diagnosed with UCB in the West Midlands from January 1991 to June 1992 (Cohort 1), and from 1168 patients newly diagnosed with UBC within the same region from December 2005 to April 2011 (Cohort 2).
  • Gender, age, smoking history, and tumour grade, stage, type, multiplicity and size at presentation were compared using a Pearson chi-square test or Cochran–Armitage trend test, as appropriate.

Result

  • Cohort 2 had a higher proportion of male patients (P = 0.021), elderly patients (P < 0.001), grade 3 tumours (P < 0.001), Ta/T1 tumours (P = 0.008), multiple tumours (P < 0.001), and tumours of ≤2 cm in diameter (P < 0.001).

Conclusions

  • There were significant differences between the cohorts.
  • These differences are potentially explained by an ageing population, changes in grading practices, improved awareness of important symptoms, improved cystoscopic technology, and reductions in treatment delays.
  • Regional cohorts remain important for identifying changes in tumour and patient characteristics that may influence disease management in the UK and beyond.
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