Novel anti-biofilm mechanism for wireless capsule endoscopy in the urinary tract: preliminary study in a sheep model
Version of Record online: 20 MAR 2013
© 2013 BJU International
Volume 111, Issue 7, pages 1156–1160, June 2013
How to Cite
Neheman, A., Schulman, C. and Yossepowitch, O. (2013), Novel anti-biofilm mechanism for wireless capsule endoscopy in the urinary tract: preliminary study in a sheep model. BJU International, 111: 1156–1160. doi: 10.1111/bju.12040
- Issue online: 9 MAY 2013
- Version of Record online: 20 MAR 2013
- bladder cancer;
- transitional cell carcinoma;
- wireless capsule endoscopy
- To develop and test the safety and feasibility of a novel anti-biofilm mechanism configured for wireless capsule endoscopy (WCE) in a sheep bladder model.
Materials and Methods
- A WCE mechanism, designed for long-term bladder monitoring, was developed and introduced into a sheep bladder for 5 months.
- The transparency of the surface was assessed by evaluating a resolution target placed inside the capsule at serial intervals using cystoscopy under general anaesthesia.
- Animal behaviour, voiding patterns and urine cultures were monitored throughout the study.
- At study termination, the capsule was extracted and assessed using scanning electron microscopy.
- The resolution target was visualized clearly at all investigation points.
- No notable adverse effects were noted during the entire follow-up period and no urinary tract infection occurred.
- Scanning electron microscopy confirmed the efficacy of the technology to prevent biofilm formation and surface encrustation.
- We report a novel technology that effectively prevents biofilm formation on the outer surface of foreign objects in the urinary tract.
- Further studies are under way to test the applicability of this technology in bladder WCE to enable high-quality wireless image transmission.