Upper Urinary Tract
Severity of hydronephrosis correlates with tumour invasiveness and urinary bladder recurrence of ureteric cancer
Article first published online: 7 JUN 2013
© 2013 BJU International
Volume 112, Issue 4, pages 489–494, August 2013
How to Cite
Luo, H. L., Kang, C. H., Chen, Y. T., Chuang, Y. C., Lee, W. C., Cheng, Y. T. and Chiang, P. H. (2013), Severity of hydronephrosis correlates with tumour invasiveness and urinary bladder recurrence of ureteric cancer. BJU International, 112: 489–494. doi: 10.1111/bju.12157
- Issue published online: 23 JUL 2013
- Article first published online: 7 JUN 2013
- bladder recurrence;
- oncologic outcome;
- predictive factor;
- organ confined;
- ureteric cancer
- To explore the prognostic role of hydronephrosis grade in patients with pure ureteric cancer.
Patients and Methods
- The study included 162 patients with pure ureteric cancer who were treated between January 2005 and December 2010 at a single tertiary referral centre.
- The association between hydronephrosis grade with pathological findings and oncological outcomes was assessed using multivariate Cox regression analysis.
- Hydronephrosis grade >2 was independently associated with non-organ-confined ureteric cancer (P = 0.003).
- Hydronephrosis grade <2 was highly prevalent in organ-confined disease.
- Hydronephrosis grade >2 and bladder cancer history independently predict bladder cancer recurrence (P = 0.021 and P = 0.002, respectively)
- Hydronephrosis of grade >2 was found to be associated with local and distant recurrence only in univariate analysis; non-organ-confined pathology independently predicted local and distant oncological failure (P ≤ 0.001 and P = 0.002, respectively).
- Hydronephrosis grade >2 is associated with non-organ-confined ureteric cancer and with bladder cancer recurrence.
- Non-organ-confined pathology is still the most important predictor for local and distant oncological failure.