Severity of hydronephrosis correlates with tumour invasiveness and urinary bladder recurrence of ureteric cancer

Authors

  • Hao Lun Luo,

    1. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
    2. Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
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  • Chih Hsiung Kang,

    1. Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
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  • Yen Ta Chen,

    1. Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
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  • Yao Chi Chuang,

    1. Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
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  • Wei Ching Lee,

    1. Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
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  • Yuan Tso Cheng,

    1. Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
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  • Po Hui Chiang

    Corresponding author
    1. Department of Urology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan
    • Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan
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Correspondence: Po Hui Chiang, Department of Urology, Kaohsiung Chang Gung Memorial Hospital, 123, Ta-Pei Road, Niaosung, Kaohsiung, Taiwan.

e-mail: tuoa480713@yahoo.com.tw

Abstract

Objectives

  • To explore the prognostic role of hydronephrosis grade in patients with pure ureteric cancer.

Patients and Methods

  • The study included 162 patients with pure ureteric cancer who were treated between January 2005 and December 2010 at a single tertiary referral centre.
  • The association between hydronephrosis grade with pathological findings and oncological outcomes was assessed using multivariate Cox regression analysis.

Results

  • Hydronephrosis grade >2 was independently associated with non-organ-confined ureteric cancer (P = 0.003).
  • Hydronephrosis grade <2 was highly prevalent in organ-confined disease.
  • Hydronephrosis grade >2 and bladder cancer history independently predict bladder cancer recurrence (P = 0.021 and P = 0.002, respectively)
  • Hydronephrosis of grade >2 was found to be associated with local and distant recurrence only in univariate analysis; non-organ-confined pathology independently predicted local and distant oncological failure (P ≤ 0.001 and P = 0.002, respectively).

Conclusions

  • Hydronephrosis grade >2 is associated with non-organ-confined ureteric cancer and with bladder cancer recurrence.
  • Non-organ-confined pathology is still the most important predictor for local and distant oncological failure.

Ancillary