Bilateral focal ablation of prostate tissue using low-energy direct current (LEDC): a preclinical canine study
Article first published online: 23 JUL 2013
© 2013 The Authors. BJU International © 2013 BJU International
Volume 112, Issue 4, pages 526–530, August 2013
How to Cite
Tsivian, M. and Polascik, T. J. (2013), Bilateral focal ablation of prostate tissue using low-energy direct current (LEDC): a preclinical canine study. BJU International, 112: 526–530. doi: 10.1111/bju.12227
- Issue published online: 23 JUL 2013
- Article first published online: 23 JUL 2013
- Accepted manuscript online: 14 MAY 2013 10:30PM EST
- focal therapy;
- To evaluate side-effects, erectile function and capability to preserve adjacent tissues of bilateral focal prostate ablation using low-energy direct current (LEDC) in a canine model.
Materials and Methods
- In all, 12 male Beagle dogs underwent bilateral focal prostate ablation using the NanoKnife™ LEDC system.
- Three 19 G monopolar electrodes were transperineally placed on each side of the prostate under transrectal ultrasonographic (TRUS) guidance using a triangular probe array.
- Intra- and postoperative side-effects were recorded. Erectile function was evaluated at baseline and 4–5 and 26–27 days after ablation.
- The dogs were killed humanely at 7 (six) and 30 days (six) for gross and microscopic evaluation of the prostate and adjacent organs.
- The median (range) prostate volume on TRUS was 12.1 (8.9–17.2) mL. The electrodes were placed at a median distance of 0.55–0.66 cm from the capsule, urethra and rectum.
- All procedures were completed successfully and recovery was uneventful. There were no episodes of urinary retention.
- All the dogs were able to achieve erections after ablation.
- Pathological analyses revealed inflammatory changes in the ablation zone at 7 days and replacement by fibrosis at 30 days. On microscopic examination no histological injury to the capsule, urethra, rectal wall or nervous structures was identified.
- In this study, bilateral focal prostate ablation using LEDC was safe and had a favourable side-effects profile limited to transient minor events.
- LEDC ablation effectively spared adjacent structures as well as physiological functions in all the dogs.