Patients with penile cancer and the risk of (pre)malignant cervical lesions in female partners: a retrospective cohort analysis


Correspondence: Simon Horenblas, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands.




  • To determine if female partners of patients with penile cancer have more cervical lesions and neoplasia than would be expected from population-based data.

Patients and Methods

  • We included all consecutive patients with primary penile carcinoma in the period 2004–2010.
  • Results of Dutch cervical cancer screening were used to consider (pre)malignant cervical lesions in female partners of patients with penile cancer.


  • In all, 206 women were included.
  • Gynaecological information was available in 195 women: Papanicolaou test (PAP) smears were normal were in 129 partners, 10 smears were abnormal (5.1%, 95% confidence interval 2.5–9.2).
  • PAP2 was found in five, PAP3a in two, PAP3b in two women and PAP4 in one woman.
  • Colposcopy in two women with PAP3b showed cervical intraepithelial neoplasia grade 3 in both.
  • This prevalence was not different from baseline results in the general Dutch population.


  • Female partners of patients with penile cancer did not show more premalignant cervical lesions than in the general population.