Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk

Authors

  • Hae Jong Kim,

    1. Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, Korea
    2. Research Institute for Biomedical and Pharmaceutical Sciences, Chung-Ang University, Seoul, Korea
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  • Kyeoung-Hwa Kim,

    1. Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, Korea
    2. Research Institute for Biomedical and Pharmaceutical Sciences, Chung-Ang University, Seoul, Korea
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  • Jaehyouk Lee,

    1. Research Institute for Translational System Biomics, Chung-Ang University College of Medicine, Seoul, Korea
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  • Jong Jin Oh,

    1. Department of Urology, CHA Bundang Medical Center, CHA University, Seongnam, Korea
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  • Hyun Sub Cheong,

    1. Department of Genetic Epidemiology, SNP Genetics Inc., Seoul, Korea
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  • Ee Lin Wong,

    1. Future Fusion Research Division, Korea Institute of Science and Technology, Seoul, Korea
    2. University of Science and Technology, Daejeon, Korea
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  • Beom-Seok Yang,

    1. Future Fusion Research Division, Korea Institute of Science and Technology, Seoul, Korea
    2. University of Science and Technology, Daejeon, Korea
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  • Seok Soo Byun,

    1. Department of Urology, Seoul National University Bundang Hospital, Seongnam, Korea
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  • Soon Chul Myung

    Corresponding author
    1. Advanced Urogenital Disease Research Center, Chung-Ang University College of Medicine, Seoul, Korea
    2. Research Institute for Biomedical and Pharmaceutical Sciences, Chung-Ang University, Seoul, Korea
    3. Department of Urology, Chung-Ang University College of Medicine, Seoul, Korea
    • Correspondence: Soon Chul Myung, Department of Urology, Chung-Ang University College of Medicine, 221 Heukseok-dong, Dongjak-ku, Seoul 156-756, Korea.

      e-mail: uromyung@cau.ac.kr

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Abstract

Objective

  • To determine whether sequence variants within the FGF23 gene are associated with the risk of developing prostate cancer in a Korean population.

Patients and Methods

  • Five common single nucleotide polymorphisms (SNPs) in the FGF23 gene were assessed in 272 patients with prostate cancer and 173 control subjects with benign prostatic hyperplasia.
  • Single-locus analyses were conducted using conditional logistic regression.
  • In addition, we performed a haplotype analysis for the five FGF23 SNPs tested.

Results

  • Three SNPs in the FGF23 gene (rs11063118, rs13312789 and rs7955866) were associated with an increased risk of prostate cancer in our study population.
  • Odds ratios for homozygous variants vs wild-type variants ranged from 1.68 (95% confidence interval [CI]: 1.15–2.46) to 1.79 (95% CI: 1.16–2.75).

Conclusion

  • This is the first study showing that genetic variations in FGF23 increase prostate cancer susceptibility.

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