MicroRNAs: critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression
Article first published online: 9 DEC 2011
Copyright © 2012 Soçiété Francaise des Microscopies and Société de Biologie Cellulaire de France
Biology of the Cell
Volume 104, Issue 1, pages 3–12, January 2012
How to Cite
Bullock, M. D., Sayan, A. E., Packham, G. K. and Mirnezami, A. H. (2012), MicroRNAs: critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression. Biology of the Cell, 104: 3–12. doi: 10.1111/boc.201100115
- Issue published online: 3 JAN 2012
- Article first published online: 9 DEC 2011
- Accepted manuscript online: 25 NOV 2011 06:10AM EST
- Manuscript Accepted: 3 NOV 2011
- Manuscript Received: 13 SEP 2011
- Cancer progression;
MicroRNAs (miRNAs) are a class of small highly conserved RNAs that provide widespread expressional control through the translational repression of mRNA. MiRNAs have fundamental roles in the regulation of intracellular processes, and their importance during malignant transformation and metastasis is becoming increasingly well recognized. An important event in the metastatic cascade is epithelial to mesenchymal transition (EMT), a reversible phenotypic switch over, which endows malignant epithelial cells with the capacity to break free from one another and invade the surrounding stroma. Our understanding of EMT has been significantly improved by the characterization of miRNAs that influence the signalling pathways and downstream events that define EMT on a molecular<?brk?> level.
Here, we detail the role of miRNAs in EMT, and in doing so demonstrate their importance in the early stages of the metastatic cascade; we discuss a significant body of data that suggest new opportunities for drug development, and we highlight critical knowledge gaps that remain to be addressed.