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  • Bartel, D.P. (2009) MicroRNAs: target recognition and regulatory functions. Cell 136, 215233
  • Batlle, E., Sancho, E., Franci, C., Dominguez, D., Monfar, M., Baulida, J., Monfar, M., Baulida, J. and Garcia De Herreros, A. (2000) The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat. Cell Biol. 2, 8489
  • Bemis, L.T., Chen, R., Amato, C.M., Classen, E.H., Robinson, S.E., Coffey, D.G., Erickson, P.F., Shellman, Y.G. and Robinson, W.A. (2008) MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines. Cancer Res. 68, 13621368
  • Bernstein, E., Kim, S.Y., Carmeil, M.A., Murchinson, E.P., Alcorn, H. and Li, M.Z. (2003) Dicer is essential for mouse development. Nat. Genet. 35, 215217
  • Brabletz, S. and Brabletz, T. (2010) The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer? EMBO Rep. 11, 670677
  • Brabletz, S., Bajdak, K., Meidhof, S., Burk, U., Niedermann, G., Dimmler, A., Faller, G., Schubert, J. and Brabletz, T. (2011) The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J. 30, 770782
  • Bracken, C.P., Gregory, P.A., Kolesnikoff, N., Bert, A.G., Wang, J., Shannon, M.F. and Goodall, G.J. (2008) A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 68, 78467854
  • Burk, U., Schubert, J., Wellner, U., Schmalhofer, O., Vincan, E., Spaderna, S. and Brabletz, T. (2008) A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 9, 582589
  • Cairo, S., Wang, Y., De Reynies, A., Duroure, K., Dahan, J., Redon, M.J., Fabre, M., McClelland, M., Wang, X.W., Croce, C.M. and Buendia, M.A. (2010) Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer. Proc. Natl. Acad. Sci. U.S.A. 107, 2047120476
  • Cano, A., Perez-Moreno, M.A., Rodrigo, I., Locascio, A., Blanco, M.J., Del Barrio, M.G., Portillo, F. and Nieto, M.A. (2000) The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2, 7683
  • Chang, C.J., Chao, C.H., Xia, W., Yang, J.Y., Xiong, Y., Li, C.W., Yu, W.H., Rehman, S.K., Hsu, J.L., Lee, H.H., Liu, M., Chen, C.T., Y, D. and Hung, M.C. (2011) p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat. Cell Biol. 13, 317323
  • Chinnadurai, G. (2009) The transcriptional co-repressor CtBP: a foe of multiple tumor suppressors. Cancer Res. 69, 731734
  • Coghlin, C. and Murray, G.I. (2010) Current and emerging concepts in tumour metastasis. J. Pathol. 222, 115
  • Comijn, J., Berx, G., Vermassen, P., Verschueren, K., van Grunsven, L., Bruyneel, E., Mareel, M., Huylebroeck, D. and van Roy, F. (2001) The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol. Cell 7, 12671278
  • Cottonham, C.L., Kaneko, S. and Xu, L. (2010) miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells. J. Biol. Chem. 285, 3529335302
  • Deng, Y., Deng, H., Bi, F., Liu, J., Bemis, L.T., Norris, D., Wang, X.J. and Zhang, Q. (2011) MicroRNA-137 targets carboxyl-terminal binding protein 1 in melanoma cell lines. Int. J. Biol. Sci. 7, 133137
  • Dykxhoorn, D.M., Wu, Y., Xie, H., Yu, F., Lal, A., Petrocca, F., Martinvalet, D., Song, E., Lim, B. and Lieberman, J. (2009) miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One 4, e7181.
  • Eades, G., Yao, Y., Yang, M., Zhang, Y., Chumsri, S. and Zhou, Q. (2011) miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells. J. Biol. Chem. 286, 2599226002
  • Eis, P.S., Tam, W., Sun, L., Chadburn, A., Li, Z., Gomez, M.F., Lund, E. and Dahlberg, J.E. (2005) Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc. Natl. Acad. Sci. U.S.A. 102, 36273632
  • Gebeshuber, C.A., Zatloukal, K. and Martinez, J. (2009) miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. EMBO Rep. 10, 400405
  • Gibbons, D.L., Lin, W., Creighton, C.J., Rizvi, Z.H., Gregory, P.A., Goodall, G.J., Thilaganathan, N., Du, L., Zhang, Y., Pertsemlidis, A. and Kurie, J.M. (2009) Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev. 23, 21402151
  • Gregory, P.A., Bert, A.G., Paterson, E.L., Barry, S.C., Tsykin, A., Farshid, G., Vadas, M.A., Khew-Goodall, Y. and Goodall, G.J. (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat. Cell Biol. 10, 593601
  • Hiscox, S., Jiang, W.G., Obermeier, K., Taylor, K., Morgan, L., Burmi, R., Barrow, D. and Nicholson, R.I. (2006) Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation. Int. J. Cancer 118, 290301
  • Hurteau, G.J., Carlson, J.A., Spivack, S.D. and Brock, G.J. (2007) Over-expression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin. Cancer Res. 67, 79727976
  • Imamichi, Y., Konig, A., Gress, T. and Menke, A. (2007) Collagen type I-induced Smad-interacting protein 1 expression downregulates E-cadherin in pancreatic cancer. Oncogene 26, 23812385
  • Iorio, M.V. and Croce, C.M. (2009) MicroRNAs in cancer: small molecules with a huge impact. J. Clin. Oncol. 27, 58485856
  • Iorio, M.V., Ferracin, M., Liu, C.G., Veronese, A., Spizzo, S., Sabbioni, E., Magri, M., Pedriali, M., Fabbri, M., Campiglio, S., Menard, J.P., Palazzo, A., Rosenberg, P., Musiani, S., Volinia, I., Nenci, G.A., Calin, P., Querzoli, M., Negrini, M. and Croce, C.M. (2005) MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65, 70657070
  • Iwatsuki, M., Mimori, K., Yokobori, T., Ishi, H., Beppu, T., Nakamori, S., Baba, H. and Mori, M. (2010) Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci. 101, 293299
  • Kajiyama, H., Shibata, K., Terauchi, M., Yamashita, M., Ino, K., Nawa, A. and Kikkawa, F. (2007) Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells. Int. J. Oncol. 31, 277283
  • Kalluri, R. and Weinberg, R.A. (2009) The basics of epithelial-mesenchymal transition. J. Clin. Invest. 119, 14201428
  • Kim, T., Veronese, A., Pichiorri, F., Lee, T.J., Jeon, Y.J., Volinia, S., Pineau, P., Marchio, A., Palatini, J., Suh, S.S., Alder, H., Liu, C.G., Dejean, A. and Croce, C.M. (2011) p53 regulates epithelial-mesenchymal transition through miRNAs targeting ZEB 1 and ZEB2. J. Exp. Med. 208, 875883
  • Koch, U. and Radke, F. (2007) Notch and cancer: a double edged sword. Cell. Mol. Life. Sci. 64, 27462762
  • Kokudo, T., Suzuki, Y., Yoshimatsu, Y., Yamazaki, T., Watabe, T. and Miyazono, K. (2008) Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells. J. Cell Sci. 121, 33173324
  • Kong, D., Banerjee, S., Ahmad, A., Li, Y., Wang, Z., Sethi, S. and Sarkar, F.H. (2010) Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells. Plos One 5, e12455.
  • Kong, W., Yang, H., He, L., Zhao, J.J., Coppola, D., Dalton, W.S. and Cheng, J.Q. (2008) MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol. Cell. Biol. 28, 67736784
  • Korpal, M., Lee, E.S., Hu, G. and Kang, Y. (2008) The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J. Biol. Chem. 283, 1491014914
  • Korpal, M., Ell, B.J., Buffa, F.M., Ibrahim, T., Blanco, M.A., Celia-Terrassa, T., Mercatali, L., Khan, Z., Goodarzi, H., Hua, Y., Wei, Y., Hu, G., Garcia, B.A., Ragoussis, J., Amadori, D., Harris, A.L. and Kang, Y. (2011) Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat. Med. 17, 11011108
  • Kumar, M.S., Lu, J., Mercer, K.L., Golub, T.R. and Jacks, J. (2007) Impared microRNA processing enhances transformation and tumourogenesis. Nat. Genet. 39, 673677
  • Li, Q.Q., Chen, Z.Q., Cao, X.X., Xu, J.D., Xu, J.W., Chen, Y.Y., Wang, W.J., Chen, Q., Tang, F., Liu, X.P. and Xu, Z.D. (2011) Involvement of NF-kappaB/miR-448 regulatory feedback loop in chemotherapy-induced epithelial-mesenchymal transition of breast cancer cells. Cell Death Differ. 18, 1625
  • Ma, L., Teruya-Feldstein, J. and Weinberg, R.A. (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449, 682688
  • Ma, L., Young, J., Prabhala, H., Pan, E., Mestdagh, P., Muth, D., Teruya-Feldstein, J., Reinhardt, F., Onder, T.T., Valastyan, S., Westermann, F., Speleman, F., Vandesompele, J. and Weinberg, R.A. (2010) miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat. Cell Biol. 12, 247256
  • Mani, S.A., Guo, W., Liao, M.J., Eaton, E.N., Ayyanan, A., Zhou, A.Y., Brooks, M., Reinhard, F., Zhang, C.C., Shipitsin, M., Campbell, L.L., Polyak, K., Brisken, C., Yang, J. and Weinberg, R.A. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133, 704715
  • Martello, G., Rosato, A., Ferrari, F., Manfrin, A., Cordensonsi, M. and Dupont, S. (2010) A microRNA targeting Dicer for metastasis control. Cell 141, 11951207
  • Massague, J. (2008) TGFbeta in cancer. Cell 134, 215230
  • Medici, D., Hay, E.D. and Olsen, B.R. (2008) Snail and slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3. Mol. Biol. Cell 19, 48754887
  • Meng, Z., Fu, X., Chen, X., Zeng, S., Tian, Y., Jove, R., Xu, R. and Huang, W. (2010) miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice. Hepatology 52, 21482157
  • Montserrat, N., Gallardo, A., Escuin, D., Catasus, L., Prat, J., Gutierrez-Avigno, F.J., Peiro, G., Barnadas, A. and Lerma, E. (2011) Repression of E-cadherin by SNAIL, ZEB1, and TWIST in invasive ductal carcinomas of the breast: a cooperative effort? Hum. Pathol. 42, 103110
  • Nielsen, B.S., Jorgensen, S., Fog, J.U., Sokilde, R., Christensen, I.J., Hansen, U., Brunner, N., Baker, A., Moller, S. and Nielsen, H.J. (2011) High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients. Clin. Exp. Metastasis 28, 2738
  • O'Hagan, H.M., Mohammad, H.P. and Baylin, S.B. (2008) Double stranded breaks can initiate gene silencing and SIRT-1 dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genet. 4, e1000155.
  • Rizzo, P., Osipo, C., Foreman, K., Golde, T., Osborne, B. and Miele, L. (2008) Rational targeting of Notch signalling in cancer. Oncogene 27, 51245131
  • Rodriguez, A., Griffiths-Jones, S., Ashurst, J.L. and Bradley, A. (2004) Identification of mammalian microRNA host genes and transcription units. Genome Res. 14, 19021910
  • Schubert, J. and Brabletz, T. (2011) p53 spreads out further: supression of EMT and stemness by activating miR-200c expression. Cell Res. 21, 705707
  • Shimono, Y., Zabala, M., Cho, R.W., Lobo, N., Dalerba, P., Qian, D., Diehn, M., Liu, H., Panula, S.P., Chiao, E., Dirbas, F.M., Somlo, G., Pera, R.A., Lao, K. and Clarke, MF. (2009) Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 138, 592603
  • Slaby, O., Svoboda, M., Fabian, P., Smerdova, T., Knoflickova, D., Bednarikova, M., Nenutil, R. and Vyzula, R. (2007) Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer. Oncology 72, 397402
  • Spaderna, S., Schmalhofer, O., Hlubek, F., Berx, G., Eger, A., Merkel, S., Jung, A., Kirchner, T. and Brabletz, T. (2006) A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology 131, 830840
  • Spaderna, S., Schmalhofer, O., Wahlbuhl, M., Dimmler, A., Bauer, K., Sultan, A., Hlubek, F., Jung, A., Strand, D., Eger, A., Kirchner, T., Behrens, J. and Brabletz, T. (2008) The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res. 68, 537544
  • Thiery, J.P. (2003) Epithelial-mesenchymal transitions in development and pathologies. Curr. Opin. Cell Biol. 15, 740746
  • Thiery, J.P., Acloque, H., Huang, R.Y. and Nieto, M.A. (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139, 871890
  • Vandewalle, C., Van Roy, F. and Berx, G. (2009) The role of the ZEB family of transcription factors in development and disease. Cell. Mol. Life Sci. 66, 773787
  • Vetter, G., Saumet, A., Moes, M., Vallar, L., Le Bechec, A., Laurini, C., Sabbah, M., Arar, K., Theillet, C., Lecellier, C.H. and Friederich, E. (2010) miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers. Oncogene 29, 44364448
  • Viswanathan, S.R., Daley, V.Q. and Gregory, R.I. (2008) Selective blockade of microRNA processing by Lin28. Science 320, 97100
  • Vousden, K.H. and Prives, C. (2009) Blinded by the light: the growing complexity of p53. Cell 137, 413431
  • Wang, Y., Baskerville, S., Shenoy, A., Babiarz, J.E., Baehner, L. and Blelloch, R. (2008) Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat. Genet. 40, 14781483
  • Wang, Z., Li, Y., Kong, D., Banerjee, S., Ahmad, A., Azmi, A.S., Ali, S., Abbruzzese, L., Gallick, G.E. and Sarkar, F.H. (2009) Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the Notch signaling pathway. Cancer Res. 69, 24002407
  • Wang, Z., Li, Y., Kong, D., Ahmad, A., Banerjee, S. and Sarkar, F.H. (2010) Cross-talk between miRNA and Notch signaling pathways in tumor development and progression. Cancer Lett. 292, 141148
  • Yang, J., Mani, S.A., Donaher, J.L., Ramaswamy, S., Itzykson, R.A., Come, C., Savagner, P., Gitelman, I., Richardson, A. and Weinberg, R.A. (2004) Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117, 927939
  • Yao, Q., Cao, S., Li, C., Mengesha, A., Kong, W. and Wei, M. (2011) Micro-RNA-21 regulates TGFβ induced myofibroblast differentiation by targeting PDCD4 in tumour-stroma interaction. Int. J. Cancer 128, 17831792
  • Yu, F., Yao, H., Zhu, P., Zhang, X., Pan, Q., Gong, C., Huang, Y., Hu, X., Su, F., Lieberman, J. and Song, E. (2007) let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131, 11091123
  • Zavadil, J. and Bottinger, E.P. (2005) TGF-beta and epithelial-to- mesenchymal transitions. Oncogene 24, 57645774