The transcriptional activity of co-activator AIB1 is regulated by the SUMO E3 Ligase PIAS1 (pages 287–296)
Shujing Li, Chunhua Yang, Yongde Hong, Hailian Bi, Feng Zhao, Ying Liu, Xiang Ao, Pengsha Pang, Xinrong Xing, Alan K. Chang, Liyun Xiao, Yuanyuan Zhang and Huijian Wu
Article first published online: 7 MAR 2012 | DOI: 10.1111/boc.201100116
Regulation of AIB1 transcriptional activity. (A) In the presence of estrogen (E2), estrogen receptor (ER) binds to the promoter of its downstream target genes, followed by the recruitment of AIB1 as well as other transcriptional co-activators (CoA) to promote the transcription of these genes. (B) PIAS1 functions as the SUMO (S) E3 ligase that increases the SUMOylation of AIB1 and attenuates its interaction with ER, resulting in the repression of ER transactivation activity.