Joshua S. Waitzman and Sarah E. Rice
Kinesin-5 motor proteins play a key role in spindle formation and maintenance during mitotic cell division. These motors are also anti-mitotic drug targets. The macromolecular structure, mechanochemical properties and regulatory mechanisms governing Kinesin-5 motors tailor them for their essential function in mitosis. This review describes the key properties of kinesin-5 motors while calling attention to critical gaps in our understanding of them.