Biology of the Cell

Cover image for Vol. 106 Issue 1

January 2014

Volume 106, Issue 1

Pages 1–43

  1. Cover Picture

    1. Top of page
    2. Cover Picture
    3. Issue Information
    4. Review
    5. Research Articles
    1. You have free access to this content
      Cover Picture

      Version of Record online: 2 JAN 2014 | DOI: 10.1111/boc.201390025

  2. Issue Information

    1. Top of page
    2. Cover Picture
    3. Issue Information
    4. Review
    5. Research Articles
    1. You have free access to this content
      Issue Information

      Version of Record online: 2 JAN 2014 | DOI: 10.1111/boc.201390026

  3. Review

    1. Top of page
    2. Cover Picture
    3. Issue Information
    4. Review
    5. Research Articles
    1. Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle (pages 1–12)

      Joshua S. Waitzman and Sarah E. Rice

      Version of Record online: 26 NOV 2013 | DOI: 10.1111/boc.201300054

      Thumbnail image of graphical abstract

      Review

      Kinesin-5 motor proteins play a key role in spindle formation and maintenance during mitotic cell division. These motors are also anti-mitotic drug targets. The macromolecular structure, mechanochemical properties and regulatory mechanisms governing Kinesin-5 motors tailor them for their essential function in mitosis. This review describes the key properties of kinesin-5 motors while calling attention to critical gaps in our understanding of them.

  4. Research Articles

    1. Top of page
    2. Cover Picture
    3. Issue Information
    4. Review
    5. Research Articles
    1. Antisense-mediated post-transcriptional silencing of SCN1B gene modulates sodium channel functional expression (pages 13–29)

      Debora Baroni, Cristiana Picco, Raffaella Barbieri and Oscar Moran

      Version of Record online: 4 DEC 2013 | DOI: 10.1111/boc.201300040

      Thumbnail image of graphical abstract

      Research article

      The silencing of sodium channel β1 subunit modulates the expression of the pore-forming α subunits both at RNA and protein level. There is a decrease of the expression levels of the α subunit proteins in neuro-ectodermal GH3 and cardiomyocyte H9C2 β1 subunit-silenced cells (see figure). The α subunit isoform-specific down-regulatory effect exerted by β1 subunit could be related to the tissue-specific modulatory action of the β1 subunit.

    2. Regulation of PKD1-mediated Golgi to cell surface trafficking by Gαq subunits (pages 30–43)

      A. Soledad Coria, M. Luján Masseroni and Alberto M. Díaz Añel

      Version of Record online: 12 DEC 2013 | DOI: 10.1111/boc.201300052

      Thumbnail image of graphical abstract

      Research article

      This manuscript describes for the first time the role of a specific Gαq subunit as an activator of a PKD1-mediated signalling pathway that regulates vesicle transport between Golgi apparatus and plasma membrane. These observations are meant to be of great significance for the scientific community, since they would help to narrow the quest for the G-protein-coupled receptors involved in the regulation of PKD1-dependent Golgi to plasma membrane vesicle trafficking.

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