- Top of page
- The Involvement of α-Synuclein in Parkinson's Disease
- The Braak Hypothesis
- Cell-to-Cell Transfer: Evidence from Human Grafting Studies
- Cell-to-Cell Release, Uptake, Transfer and Seeding of α-Synuclein: Evidence from in vitro and in vivo Studies
- Crucial Factors Affecting the Capacity of α-Synuclein to Act in a Prion-Like Fashion
- Axonal Transport of α-Synuclein: is α-Synuclein the Long Distance Runner?
- An Evaluation of the Braak Staging
- Conflict of interest
Parkinson's disease is characterized by α-synuclein pathology in the form of Lewy bodies and Lewy neurites. Braak et al described the spatial and temporal spread of α-synuclein pathology in Parkinson's disease. Recent experimental studies have demonstrated that α-synuclein can transfer from cell to cell. In this review, we highlight the involvement of α-synuclein in Parkinson's disease and in Braak's staging of Parkinson's disease pathology. We discuss whether a prion-like mechanism of α-synuclein spread might contribute to Parkinson's disease pathology. We describe recent studies investigating cell-to-cell transfer of α-synuclein and focus our review on the long-distance axonal transport of α-synuclein along neurons.