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Figure S1. BRAF V600E mutated ganglioglioma (GG): CD34, MHC-II and MHC-I immunoreactivity. A, B. Prominent CD34 immunoreactivity (IR) within the tumor area. C–E. Prominent MHC class II antigen (MHC-II) expression within the tumor area, with IR in microglial cells (arrows in D and E) and occasionally in large dysplastic neurons (arrowhead in E). F, G. Prominent MHC class I antigen (MHC-I) expression within the tumor area, with IR in large dysplastic neurons (arrows in G). Scale bar in (G): A, C, F: 400 μm; B, G: 80 μm; D, E: 40 μm.

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Figure S2. BRAF V600E mutated ganglioglioma (GG): pLKB1. A–C. Phosphorylated (p)-LKB1 immunoreactivity (IR) within the tumor area in large dysplastic neurons (arrows in A; B, C); co-localization of pLKB1 with VE1 is shown in the insert in (A). Scale bar in (C): A. 40 μm; B, C. 20 μm.

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Figure S3. VE1 immunoreactivity in ganglioglioma (GG) and in control cortex. A. GG with only few VE1-positive dysplastic neurons (arrows and insert). B. Perilesional cortex without VE1 immunoreactivity (IR). Scale bar in (B): A. 80 μm; B. 160 μm.

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Figure S4. MHC-I, MHC-II and pS6 immunoreactivity score (IRS) in GGs and DNTs. A. MHC-I (glial/neuronal) and MHC-II IR scores (total score; mean ± SEM) in GGs and DNTs. B. pS6 (glial/neuronal) IR scores (total score; mean ± SEM) in GGs and DNTs (***P < 0.001). Desmoplastic infantile gangliogliomas (DIGs); gangliogliomas (GGs); dysembryoplastic neuroepithelial tumors (DNTs); dysplastic neurons (DN).

bpa12081-sup-0005-si.doc73K

Table S1. Criteria to distinguish diffuse DNTs from other DNT types.

Table S2. Correlation of pS6 IRS with clinical data and histological/immunohistochemical features in GGs and DNTs.

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