Nitrite in organ protection

Authors

  • Tienush Rassaf,

    Corresponding author
    1. Department of Medicine, Division of Cardiology, Pulmonary and Vascular Medicine, University Hospital Düsseldorf, Düsseldorf, Germany
    • Correspondence

      Prof Dr Tienush Rassaf, Division of Cardiology, Pulmonary and Vascular Medicine, Medical Faculty, University Hospital Düsseldorf, Moorenstrasse 5, D-40225 Düsseldorf, Germany. E-mail: tienush.rassaf@med.uni-duesseldorf.de

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  • Peter Ferdinandy,

    1. Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    2. Pharmahungary Group, Szeged, Hungary
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  • Rainer Schulz

    1. Department of Physiology, Justus-Liebig-University, Giessen, Germany
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  • Commissioning Editor: Peter Ferdinandy

Abstract

In the last decade, the nitrate-nitrite-nitric oxide pathway has emerged to therapeutical importance. Modulation of endogenous nitrate and nitrite levels with the subsequent S-nitros(yl)ation of the downstream signalling cascade open the way for novel cytoprotective strategies. In the following, we summarize the actual literature and give a short overview on the potential of nitrite in organ protection.

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