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bph12458-sup-0001-si.tif257K

Figure S1 Shows overlays of the chemical structures of the four loop diuretics studied.

bph12458-sup-0002-si.tif2011K

Figure S2 Uses noise analysis to explore the kinetics of CFTR block by loop diuretics.

bph12458-sup-0003-si.tif1080K

Figure S3 Investigates whether loop diuretics are allosteric blockers of CFTR by exploring whether changing the intracellular ATP concentration affects the efficacy of channel block.

bph12458-sup-0004-si.tif15586K

Figure S4 Examines whether loop diuretic-blocked channels reopen first before closing on washout of loop diuretic, PKA and ATP from the intracellular solution.

bph12458-sup-0005-si.docx40K

Table S1 Effects of loop diuretics on corner frequencies derived from spectral analysis of CFTR Cl currents.

Table S2 Effects of furosemide and piretanide on the open- and closed-time constants of wild-type CFTR.

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