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References

  • Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM (2005). Ca2+/calmodulin protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res 97: 13141322.
  • Anderson ME, Braun AP, Wu Y, Lu T, Wu Y, Schulman H et al. (1998). KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther 287: 9961006.
  • Andersson KB, Birkeland JAK, Finsen AV, Louch WE, Sjaastad I, Wang Y et al. (2009). Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol 47: 180187.
  • Antipenko AY, Spielman AI, Kirchberger MA (1999). Interactions of 6-gingerol and ellagic acid with the cardiac sarcoplasmic reticulum Ca2+-ATPase. J Pharmacol Exp Ther 290: 227234.
  • Aracena P, Tang W, Hamilton SL, Hidalgo C (2005). Effects of S-glutathionylation and S-nitrosylation on calmodulin binding to triads and FKBP12 binding to type 1 calcium release channels. Antioxid Redox Signal 7: 870881.
  • Babu GJ, Bhupathy P, Carnes CA, Billman GE, Periasamy M (2007a). Differential expression of sarcolipin protein during muscle development and cardiac pathophysiology. J Mol Cell Cardiol 43: 215222.
  • Babu GJ, Bhupathy P, Timofeyev V, Petrashevskaya NN, Reiser PJ, Chiamvimonvat N et al. (2007b). Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility. Proc Natl Acad Sci USA 104: 1786717872.
  • Bers DM (2001). Excitation-Contraction Coupling and Cardiac Contractile Force, 2nd edn. Kluwer Academic Publishers: Dodrecht, The Netherlands.
  • Bers DM (2002). Cardiac excitation-contraction coupling. Nature 415: 198205.
  • Beuckelmann DJ, Nabauer M, Erdmann E (1992). Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation 85: 10461055.
  • Beuckelmann DJ, Nabauer M, Erdmann E (1993). Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ Res 73: 379385.
  • Bode EF, Briston SJ, Overend CL, O'Neill SC, Trafford AW, Eisner DA (2011). Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca2+ content in rat ventricular myocytes. J Physiol 589 (Pt 19): 47234729.
  • Byrne MJ, Power JM, Preovolos A, Mariani JA, Hajjar RJ, Kaye DM (2008). Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals. Gene Ther 15: 15501557.
  • Calabrese F, Thiene G (2003). Myocarditis and inflammatory cardiomyopathy: microbiological and molecular biological aspects. Cardiovasc Res 60: 1125.
  • Cannell MB, Cheng H, Lederer WJ (1995). The control of calcium release in heart muscle. Science 268: 10451049.
  • Carvalho BM, Bassani RA, Franchini KG, Bassani JW (2006). Enhanced calcium mobilization in rat ventricular myocytes during the onset of pressure overload-induced hypertrophy. Am J Physiol Heart Circ Physiol 291: H1803H1813.
  • Chen Y, Escoubet B, Prunier F, Amour J, Simonides WS, Vivien B et al. (2004). Constitutive cardiac overexpression of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase delays myocardial failure after myocardial infarction in rats at a cost of increased acute arrhythmias. Circulation 109: 18981903.
  • Cheng H, Lederer WJ, Cannell MB (1993). Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science 262: 740744.
  • Cheng H, Lederer MR, Lederer WJ, Cannell MB (1996). Calcium sparks and [Ca2+]i waves in cardiac myocytes. Am J Physiol 270 (1 Pt 1): C148C159.
  • Cheng SH, Smith AE (2013). Gene therapy progress and prospects: gene therapy of lysosomal storage disorders. Gene Ther 10: 12751281.
  • Chopra N, Kannankeril PJ, Yang T, Hlaing T, Holinstat I, Ettensohn K et al. (2007). Modest reductions of cardiac calsequestrin increase sarcoplasmic reticulum Ca2+ leak independent of luminal Ca2+ and trigger ventricular arrhythmias in mice. Circ Res 101: 617626.
  • Cornea RL, Jones LR, Autry JM, Thomas DD (1997). Mutation and phosphorylation change the oligomeric structure of phospholamban in lipid bilayers. Biochemistry 36: 29602967.
  • Cox DE, Farmer LD, Hoyle JR, Wells GL (2005). Prognostic significance of nonsustained ventricular tachycardia during dobutamine stress echocardiography. Am J Cardiol 96: 12931298.
  • Cutler MJ, Wan X, Laurita KR, Hajjar RJ, Rosenbaum DS (2009). Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans. Circ Arrhythmia Electrophysiol 2: 686694.
  • Cutler MJ, Plummer BN, Wan X, Sun QA, Hess D, Liu H et al. (2012a). Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart. Proc Natl Acad Sci USA 109: 1818618191.
  • Cutler MJ, Wan X, Plummer BN, Liu H, Deschenes I, Laurita KR et al. (2012b). Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart. Circulation 126: 20952104.
  • Davia K, Bernobich E, Ranu HK, del Monte F, Terracciano CMN, MacLeod KT et al. (2001). SERCA2a overexpression decreases the incidence of aftercontractions in adult rabbit ventricular myocytes. J Mol Cell Cardiol 33: 10051015.
  • Duchen MR, Verkhratsky A, Muallem S (2008). Mitochondria and calcium in health and disease. Cell Calcium 44: 15.
  • Dupont Y (1977). Kinetics and regulation of sarcoplasmic reticulum ATPase. Eur J Biochem 72: 185190.
  • Feldman AM, Weinberg EO, Ray PE, Lorell BH (1993). Selective changes in cardiac gene expression during compensated hypertrophy and the transition to cardiac decompensation in rats with chronic aortic banding. Circ Res 73: 184192.
  • Flesch M, Schiffer F, Zolk O, Pinto Y, Rosenkranz S, Hirth-Dietrich C et al. (1997). Contractile systolic and diastolic dysfunction in renin-induced hypertensive cardiomyopathy. Hypertension 30: 383391.
  • Frank K, Tilgmann C, Shannon TR, Bers DM, Kranias EG (2000). Regulatory role of phospholamban in the efficiency of cardiac sarcoplasmic reticulum Ca2+ transport. Biochemistry 39: 1417614182.
  • Franzini-Armstrong C (1975). Membrane particles and transmission at the triad. Fed Proc 34: 13821389.
  • Gheorghiade M, Blair JE, Filippatos GS, Macarie C, Ruzyllo W, Korewicki J et al. (2008). Hemodynamic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failure. J Am Coll Cardiol 51: 22762285.
  • Giordano FJ, He H, McDonough P, Meyer M, Sayen MR, Dillmann WH (1997). Adenovirus-mediated gene transfer reconstitutes depressed sarcoplasmic reticulum Ca2+-ATPase levels and shortens prolonged cardiac myocyte Ca2+ transients. Circulation 96: 400403.
  • Gomez AM, Cheng H, Lederer WJ, Bers DM (1996). Ca2+ diffusion and sarcoplasmic reticulum transport both contribute to [Ca2+]i decline during Ca2+ sparks in rat ventricular myocytes. J Physiol 496 (Pt 2): 575581.
  • Gwathmey JK, Morgan JP (1985). Altered calcium handling in experimental pressure-overload hypertrophy in the ferret. Circ Res 57: 836843.
  • Gwathmey JK, Copelas L, MacKinnon R, Schoen FJ, Feldman MD, Grossman W et al. (1987). Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circ Res 61: 7076.
  • Gyorke I, Gyorke S (1998). Regulation of the cardiac ryanodine receptor channel by luminal Ca2+ involves luminal Ca2+ sensing sites. Biophys J 75: 28012810.
  • Hadri L, Bobe R, Kawase Y, Ladage D, Ishikawa K, Atassi F et al. (2010). SERCA2a gene transfer enhances eNOS expression and activity in endothelial cells. Mol Ther 18: 12841292.
  • Hagemann D, Kuschel M, Kuramochi T, Zhu W, Cheng H, Xiao RP (2000). Frequency-encoding Thr17 phospholamban phosphorylation is independent of Ser16 phosphorylation in cardiac myocytes. J Biol Chem 275: 2253222536.
  • Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO et al. (2003). Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. J Clin Invest 111: 869876.
  • Hajjar RJ, Kang JX, Gwathmey JK, Rosenzweig A (1997). Physiological effects of adenoviral gene transfer of sarcoplasmic reticulum calcium ATPase in isolated rat myocytes. Circulation 95: 423429.
  • Hajjar RJ, Zsebo K, Deckelbaum L, Thompson C, Rudy J, Yaroshinsky A et al. (2008). Design of a phase 1/2 trial of intracoronary administration of AAV1/SERCA2a in patients with heart failure. J Card Fail 14: 355367.
  • Hasenfuss G (1998). Alterations of calcium-regulatory proteins in heart failure. Cardiovasc Res 37: 279289.
  • Hasenfuss G, Schillinger W, Lehnart SE, Preuss M, Pieske B, Maier LS et al. (1999). Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium. Circulation 99: 641648.
  • Higgins ER, Cannell MB, Sneyd J (2006). A buffering SERCA pump in models of calcium dynamics. Biophys J 91: 151163.
  • Hoshijima M (2005). Gene therapy targeted at calcium handling as an approach to the treatment of heart failure. Pharmacol Ther 105: 211228.
  • Hou Z, Kelly EM, Robia SL (2008). Phosphomimetic mutations increase phospholamban oligomerization and alter the structure of its regulatory complex. J Biol Chem 283: 2899629003.
  • Huang X, Liu L (2007). A joint frailty model for survival and gap times between recurrent events. Biometrics 63: 389397.
  • Huq F, del Monte F, Hajjar RJ (2002). Modulating signaling pathways in hypertrophy and heart failure by gene transfer. J Card Fail 8 (6, Part 2): S389S400.
  • Iribe G, Ward CW, Camelliti P, Bollensdorff C, Mason F, Burton RA et al. (2009). Axial stretch of rat single ventricular cardiomyocytes causes an acute and transient increase in Ca2+ spark rate. Circ Res 104: 787795.
  • Jane Lalli M, Yong J, Prasad V, Hashimoto K, Plank D, Babu GJ et al. (2001). Sarcoplasmic reticulum Ca2+ ATPase (SERCA) 1a structurally substitutes for SERCA2a in the cardiac sarcoplasmic reticulum and increases cardiac Ca2+ handling capacity. Circ Res 89: 160167.
  • Janse MJ, Coronel R, Wilms-Schopman FJ, de Groot JR (2003). Mechanical effects on arrhythmogenesis: from pipette to patient. Prog Biophys Mol Biol 82: 187195.
  • Jaski BE, Jessup ML, Mancini DM, Cappola TP, Pauly DF, Greenberg B et al. (2009). Calcium upregulation by percutaneous administration of gene therapy in cardiac disease (CUPID trial), a first-in-human phase 1/2 clinical trial. J Card Fail 15: 171181.
  • Jessup M, Greenberg B, Mancini D, Cappola T, Pauly DF, Jaski B et al. (2011). Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure. Circulation 124: 304313.
  • Jhund PS, Macintyre K, Simpson CR, Lewsey JD, Stewart S, Redpath A et al. (2009). Long-term trends in first hospitalization for heart failure and subsequent survival between 1986 and 2003: a population study of 5.1 million people. Circulation 119: 515523.
  • Jiang D, Xiao B, Yang D, Wang R, Choi P, Zhang L et al. (2004). RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR). Proc Natl Acad Sci USA 101: 1306213067.
  • Kaab S, Nuss HB, Chiamvimonvat N, O'Rourke B, Pak PH, Kass DA et al. (1996). Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 78: 262273.
  • Kass RS, Lindegger N, Hagen B, Lederer WJ (2008). Another calcium paradox in heart failure. J Mol Cell Cardiol 45: 2831.
  • Kawase Y, Ly HQ, Prunier F, Lebeche D, Shi Y, Jin H et al. (2008). Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure. J Am Coll Cardiol 51: 11121119.
  • Keller M, Kao JP, Egger M, Niggli E (2007). Calcium waves driven by ‘sensitization’ wave-fronts. Cardiovasc Res 74: 3945.
  • ter Keurs HE (2011). Electromechanical coupling in the cardiac myocyte; stretch-arrhythmia feedback. Pflugers Arch 462: 165175.
  • Kho C, Lee A, Jeong D, Oh JG, Chaanine AH, Kizana E et al. (2011). SUMO1-dependent modulation of SERCA2a in heart failure. Nature 477: 601605.
  • Kho C, Lee A, Hajjar RJ (2012). Altered sarcoplasmic reticulum calcium cycling – targets for heart failure therapy. Nat Rev Cardiol 9: 717733.
  • Kimura Y, Kurzydlowski K, Tada M, MacLennan DH (1997). Phospholamban inhibitory function is activated by depolymerization. J Biol Chem 272: 1506115064.
  • Kushnir A, Marks AR (2010). The ryanodine receptor in cardiac physiology and disease. Adv Pharmacol 59: 130.
  • Leberer E, Hartner KT, Brandl CJ, Fujii J, Tada M, MacLennan DH et al. (1989). Slow/cardiac sarcoplasmic reticulum Ca2+-ATPase and phospholamban mRNAs are expressed in chronically stimulated rabbit fast-twitch muscle. Eur J Biochem 185: 5154.
  • Linck B, Boknik P, Baba HA, Eschenhagen T, Haverkamp U, Jackel E et al. (1998). Long-term beta adrenoceptor-mediated alteration in contractility and expression of phospholamban and sarcoplasmic reticulum Ca(++)-ATPase in mammalian ventricle. J Pharmacol Exp Ther 286: 531538.
  • Lipp P, Niggli E (1996). Submicroscopic calcium signals as fundamental events of excitation–contraction coupling in guinea-pig cardiac myocytes. J Physiol 492 (Pt 1): 3138.
  • Lipp P, Niggli E (1998). Fundamental calcium release events revealed by two-photon excitation photolysis of caged calcium in guinea-pig cardiac myocytes. J Physiol 508: 801809.
  • Lipskaia L, del Monte F, Capiod T, Yacoubi S, Hadri L, Hours M et al.(2005). Sarco/endoplasmic reticulum Ca2+-ATPase gene transfer reduces vascular smooth muscle cell proliferation and neointima formation in the rat. Circ Res 97: 488495.
  • Lipskaia L, Hadri L, Le PP, Esposito B, Atassi F, Liang L et al. (2013). SERCA2a gene transfer prevents intimal proliferation in an organ culture of human internal mammary artery. Gene Ther 20: 396406.
  • Lloyd-Jones DM, Larson MG, Leip EP, Beiser A, D'Agostino RB, Kannel WB et al. (2002). Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation 106: 30683072.
  • Lopez-Lopez JR, Shacklock PS, Balke CW, Wier WG (1995). Local calcium transients triggered by single L-type calcium channel currents in cardiac cells. Science 268: 10421045.
  • Louch WE, Hougen K, Mork HK, Swift F, Aronsen JM, Sjaastad I et al. (2010). Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout. J Physiol 588: 465478.
  • Louis JV, Joergensen JA, Hajjar RJ, Weber T (2013). Pre-existing anti-adeno-associated virus antibodies as a challenge in AAV gene therapy. Hum Gene Ther Methods 24: 5967.
  • Lyon AR, Sato M, Hajjar RJ, Samulski RJ, Harding SE (2008). Gene therapy: targeting the myocardium. Heart 94: 8999.
  • Lyon AR, MacLeod KT, Zhang Y, Garcia E, Kanda GK, Lab MJ et al. (2009). Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc Natl Acad Sci USA 106: 68546859.
  • Lyon AR, Bannister ML, Collins T, Pearce E, Sepehripour AH, Dubb SS et al. (2011). SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure. Circ Arrhythm Electrophysiol 4: 362372.
  • Lyon AR, Nikolaev VO, Miragoli M, Sikkel MB, Paur H, Benard L et al. (2012). Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circ Heart Fail 5: 357365.
  • MacLennan DH, Green NM (2000). Structural biology: pumping ions. Nature 405: 633634.
  • MacLennan DH, Kranias EG (2003). Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4: 566577.
  • Maltsev VA, Lakatta EG (2009). Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model. Am J Physiol Heart Circ Physiol 296: H594H615.
  • Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N et al. (2000). PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101: 365376.
  • Maxwell JT, Blatter LA (2012). Facilitation of cytosolic calcium wave propagation by local calcium uptake into the sarcoplasmic reticulum in cardiac myocytes. J Physiol 590 (Pt 23): 60376045.
  • Meyer M, Bluhm WF, He H, Post SR, Giordano FJ, Lew WYW et al. (1999). Phospholamban-to-SERCA2 ratio controls the force-frequency relationship. Am J Physiol Heart Circ Physiol 276: H779H785.
  • Mi YF, Li XY, Tang LJ, Lu XC, Fu ZQ, Ye WH (2009). Improvement in cardiac function after sarcoplasmic reticulum Ca2+-ATPase gene transfer in a beagle heart failure model. Chin Med J (Engl) 122: 14231428.
  • Micheletti R, Palazzo F, Barassi P, Giacalone G, Ferrandi M, Schiavone A et al. (2007). Istaroxime, a stimulator of sarcoplasmic reticulum calcium adenosine triphosphatase isoform 2a activity, as a novel therapeutic approach to heart failure. Am J Cardiol 99 (2, Suppl.): S24S32.
  • Mills GD, Kubo H, Harris DM, Berretta RM, Piacentino V, III, Houser SR (2006). Phosphorylation of phospholamban at threonine-17 reduces cardiac adrenergic contractile responsiveness in chronic pressure overload-induced hypertrophy. Am J Physiol Heart Circ Physiol 291: H61H70.
  • Miyamoto MI, del Monte F, Schmidt U, DiSalvo TS, Kang ZB, Matsui T et al.(2000). Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci USA 97: 793798.
  • del Monte F, Hajjar RJ (2003). Targeting calcium cycling proteins in heart failure through gene transfer. J Physiol 546: 4961.
  • del Monte F, O'Gara P, Poole-Wilson PA, Yacoub M, Harding SE (1995). Cell geometry and contractile abnormalities of myocytes from failing human left ventricle. Cardiovasc Res 30: 281290.
  • del Monte F, Harding SE, Schmidt U, Matsui T, Kang ZB, Dec GW et al. (1999). Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation 100: 23082311.
  • del Monte F, Williams E, Lebeche D, Schmidt U, Rosenzweig A, Gwathmey JK et al. (2001). Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase in a rat model of heart failure. Circulation 104: 14241429.
  • del Monte F, Lebeche D, Guerrero JL, Tsuji T, Doye AA, Gwathmey JK et al. (2004). Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. Proc Natl Acad Sci USA 101: 56225627.
  • Muller S, How OJ, Jakobsen O, Hermansen SE, Rosner A, Stenberg TA et al. (2010). Oxygen-wasting effect of inotropy: is there a need for a new evaluation? An experimental large-animal study using dobutamine and levosimendan. Circ Heart Fail. 3: 277285.
  • Nuss HB, Kaab S, Kass DA, Tomaselli GF, Marban E (1999). Cellular basis of ventricular arrhythmias and abnormal automaticity in heart failure. Am J Physiol 277 (1 Pt 2): H80H91.
  • O'Connor CM, Gattis WA, Uretsky BF, Adams KF, Jr, McNulty SE, Grossman SH et al. (1999). Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: insights from the Flolan International Randomized Survival Trial (FIRST). Am Heart J 138 (1 Pt 1): 7886.
  • O'Donnell JM, Fields A, Xu X, Chowdhury SA, Geenen DL, Bi J (2008). Limited functional and metabolic improvements in hypertrophic and healthy rat heart overexpressing the skeletal muscle isoform of SERCA1 by adenoviral gene transfer in vivo. Am J Physiol Heart Circ Physiol 295: H2483H2494.
  • Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM (2006). Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 355: 251259.
  • Pacak CA, Mah CS, Thattaliyath BD, Conlon TJ, Lewis MA, Cloutier DE et al. (2006). Recombinant adeno-associated virus serotype 9 leads to preferential cardiac transduction in vivo. Circ Res 99: e3e9.
  • Packer M, Medina N, Yushak M (1984). Hemodynamic and clinical limitations of long-term inotropic therapy with amrinone in patients with severe chronic heart failure. Circulation 70: 10381047.
  • Packer M, Carver JR, Rodeheffer RJ, Ivanhoe RJ, DiBianco R, Zeldis SM et al. (1991). Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. N Engl J Med 325: 14681475.
  • Palomeque J, Chemaly ER, Colosi P, Wellman JA, Zhou S, del Monte F et al.(2007). Efficiency of eight different AAV serotypes in transducing rat myocardium in vivo. Gene Ther 14: 989997.
  • Penson PE, Ford WR, Broadley KJ (2007). Vasopressors for cardiopulmonary resuscitation. Does pharmacological evidence support clinical practice? Pharmacol Ther 115: 3755.
  • Periasamy M, Reed TD, Liu LH, Ji Y, Loukianov E, Paul RJ et al. (1999). Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene. J Biol Chem 274: 25562562.
  • Pieske B, Hasenfuss G, Holubarsch C, Schwinger R, Bohm M, Just H (1992). Alterations of the force-frequency relationship in the failing human heart depend on the underlying cardiac disease. Basic Res Cardiol 87 (Suppl. 1): 213221.
  • Pogwizd SM, Schlotthauer K, Li L, Yuan W, Bers DM (2001). Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness. Circ Res 88: 11591167.
  • Prosser BL, Ward CW, Lederer WJ (2011). X-ROS signaling: rapid mechano-chemo transduction in heart. Science 333: 14401445.
  • Prunier F, Kawase Y, Gianni D, Scapin C, Danik SB, Ellinor PT et al. (2008). Prevention of ventricular arrhythmias with sarcoplasmic reticulum Ca2+ ATPase pump overexpression in a porcine model of ischemia reperfusion. Circulation 118: 614624.
  • Respress JL, van Oort RJ, Li N, Rolim N, Dixit SS, deAlmeida A et al. (2012). Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res 110: 14741483.
  • Rocchetti M, Besana A, Mostacciuolo G, Ferrari P, Micheletti R, Zaza A (2003). Diverse toxicity associated with cardiac Na+/K+ pump inhibition: evaluation of electrophysiological mechanisms. J Pharmacol Exp Ther 305: 765771.
  • Rocchetti M, Besana A, Mostacciuolo G, Micheletti R, Ferrari P, Sarkozi S et al. (2005). Modulation of sarcoplasmic reticulum function by Na+/K+ pump inhibitors with different toxicity: digoxin and PST2744 [(E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride]. J Pharmacol Exp Ther 313: 207215.
  • Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang LF et al. (2006). Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer. Mol Ther 13: 987996.
  • Sakata S, Lebeche D, Sakata N, Sakata Y, Chemaly ER, Liang LF et al. (2007a). Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins. J Mol Cell Cardiol 42: 852861.
  • Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang L et al. (2007b). Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model. Am J Physiol Heart Circ Physiol 292: H1204H1207.
  • Schmidt U, Hajjar RJ (2001). Gene therapy in heart failure. Best Pract Res Clin Anaesthesiol 15: 301312.
  • Schmidt U, Hajjar RJ, Helm PA, Kim CS, Doye AA, Gwathmey JK (1998). Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure. J Mol Cell Cardiol 30: 19291937.
  • Schulte LM, Navarro J, Kandarian SC (1993). Regulation of sarcoplasmic reticulum calcium pump gene expression by hindlimb unweighting. Am J Physiol 264 (5 Pt 1): C1308C1315.
  • Schultz JJ, Glascock BJ, Witt SA, Nieman ML, Nattamai KJ, Liu LH et al. (2004). Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity. Am J Physiol Heart Circ Physiol 286: H1146H1153.
  • 3nch, B÷lck, Karczewski, Krause, Erdmann; 1999)Schwinger RHG, M3nch G, B÷lck B, Karczewski P, Krause EG, Erdmann E (1999). Reduced Ca2+-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phoshorylation. J Mol Cell Cardiol 31: 479491.
  • Shannon TR, Ginsburg KS, Bers DM (2002). Quantitative assessment of the SR Ca2+ leak-load relationship. Circ Res 91: 594600.
  • Sodi R, Dubuis E, Shenkin A, Hart G (2008). B-type natriuretic peptide (BNP) attenuates the L-type calcium current and regulates ventricular myocyte function. Regul Pept 151: 95105.
  • Song LS, Pi Y, Kim SJ, Yatani A, Guatimosim S, Kudej RK et al. (2005). Paradoxical cellular Ca2+ signaling in severe but compensated canine left ventricular hypertrophy. Circ Res 97: 457464.
  • Song LS, Sobie EA, McCulle S, Lederer WJ, Balke CW, Cheng H (2006). Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci USA 103: 43054310.
  • Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T et al. (2010). Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium. Circ Res 107: 11501161.
  • Stewart PS, MacLennan DH (1974). Surface particles of sarcoplasmic reticulum membranes. Structural features of the adenosine triphosphatase. J Biol Chem 249: 985993.
  • Swedberg K, Komajda M, Bohm M, Borer JS, Ford I, Dubost-Brama A et al. (2010). Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet 376: 875885.
  • Tada M, Kirchberger MA, Katz AM (1975). Phosphorylation of a 22,000-dalton component of the cardiac sarcoplasmic reticulum by adenosine 3′:5′-monophosphate-dependent protein kinase. J Biol Chem 250: 26402647.
  • Talosi L, Edes I, Kranias EG (1993). Intracellular mechanisms mediating reversal of beta-adrenergic stimulation in intact beating hearts. Am J Physiol 264 (3 Pt 2): H791H797.
  • Teerlink JR, Clarke CP, Saikali KG, Lee JH, Chen MM, Escandon RD et al. (2011). Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study. Lancet 378: 667675.
  • Terracciano CM, Hajjar RJ, Harding SE (2002). Overexpression of SERCA2a accelerates repolarisation in rabbit ventricular myocytes. Cell Calcium 31: 299305.
  • Teucher N, Prestle J, Seidler T, Currie S, Elliott EB, Reynolds DF et al. (2004). Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening. Circulation 110: 35533559.
  • Toma M, Starling RC (2010). Inotropic therapy for end-stage heart failure patients. Curr Treat Options Cardiovasc Med 12: 409419.
  • Trafford AW, Diaz ME, Sibbring GC, Eisner DA (2000). Modulation of CICR has no maintained effect on systolic Ca2+: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca2+ fluxes in rat ventricular myocytes. J Physiol 522 (Pt 2): 259270.
  • Vassort G, Lacampagne A (2005). The role of ryanodine receptors and consequences of their alterations during cardiac insufficiency. Exp. Clin Cardiol. 10: 196199.
  • Vermeulen JT (1998). Mechanisms of arrhythmias in heart failure. J Cardiovasc Electrophysiol 9: 208221.
  • Volders PGA, Vos MA, Szabo B, Sipido KR, de Groot SHM, Gorgels APM et al. (2000). Progress in the understanding of cardiac early afterdepolarizations and torsades de pointes: time to revise current concepts. Cardiovasc Res 46: 376392.
  • Wehrens XH, Lehnart SE, Reiken S, van der Nagel R, Morales R, Sun J et al. (2005). Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci USA 102: 96079612.
  • Weiss JN, Qu Z, Chen PS, Lin SF, Karagueuzian HS, Hayashi H et al. (2005). The dynamics of cardiac fibrillation. Circulation 112: 12321240.
  • Weiss JN, Nivala M, Garfinkel A, Qu Z (2011). Alternans and arrhythmias: from cell to heart. Circ Res 108: 98112.
  • Wuytack F, Raeymaekers L, Missiaen L (2002). Molecular physiology of the SERCA and SPCA pumps. Cell Calcium 32: 279305.
  • Xie LH, Sato D, Garfinkel A, Qu Z, Weiss JN (2008). Intracellular Ca alternans: coordinated regulation by sarcoplasmic reticulum release, uptake, and leak. Biophys J 95: 31003110.
  • Yang D, Zhu WZ, Xiao B, Brochet DX, Chen SR, Lakatta EG et al. (2007). Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. Circ Res 100: 399407.
  • Yang Y, Nunes FA, Berencsi K, Furth EE, Gonczol E, Wilson JM (1994). Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA 91: 44074411.
  • Yuan Q, Fan GC, Dong M, Altschafl B, Diwan A, Ren X et al. (2007). Sarcoplasmic reticulum calcium overloading in junctin deficiency enhances cardiac contractility but increases ventricular automaticity. Circulation 115: 300309.
  • Zeng J, Rudy Y (1995). Early afterdepolarizations in cardiac myocytes: mechanism and rate dependence. Biophys J 68: 949964.
  • Zhao W, Uehara Y, Chu G, Song Q, Qian J, Young K et al. (2004). Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility. J Mol Cell Cardiol 37: 607612.
  • Zhao Z, Wen H, Fefelova N, Allen C, Baba A, Matsuda T et al. (2012). Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents? Am J Physiol Heart Circ Physiol 302: H1636H1644.
  • Zima AV, Blatter LA (2006). Redox regulation of cardiac calcium channels and transporters. Cardiovasc Res 71: 310321.
  • Zima AV, Bovo E, Bers DM, Blatter LA (2010). Ca2+ spark-dependent and -independent sarcoplasmic reticulum Ca2+ leak in normal and failing rabbit ventricular myocytes. J Physiol 588: 47434757.
  • Zissimopoulos S, Docrat N, Lai FA (2007). Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein. J Biol Chem 282: 69766983.