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British Journal of Pharmacology

© The British Pharmacological Society

Cover image for British Journal of Pharmacology

Special Issue: Themed Issue: Safety Pharmacology: Guest Editor: Michael Pugsley

August 2008

Volume 154, Issue 7

Pages 1379–1553

  1. Commentary

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    2. Commentary
    3. Reviews
    4. Research Papers
    5. Themed Section Commentary
    6. Themed Section Reviews
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      The failure of torcetrapib: what have we learned? (pages 1379–1381)

      T R Joy and R A Hegele

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.248

  2. Reviews

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    2. Commentary
    3. Reviews
    4. Research Papers
    5. Themed Section Commentary
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      Principles of Safety Pharmacology (pages 1382–1399)

      M K Pugsley, S Authier and M J Curtis

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.280

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      Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery (pages 1400–1413)

      T P Barros, W K Alderton, H M Reynolds, A G Roach and S Berghmans

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.249

  3. Research Papers

    1. Top of page
    2. Commentary
    3. Reviews
    4. Research Papers
    5. Themed Section Commentary
    6. Themed Section Reviews
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      Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs (pages 1414–1426)

      G Michael, K A Kane and S J Coker

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.169

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      Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines (pages 1427–1438)

      H R Lu, E Vlaminckx, A N Hermans, J Rohrbacher, K Van Ammel, R Towart, M Pugsley and D J Gallacher

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.191

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      Dose–response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys (pages 1439–1445)

      J J Lynch III, A W Wilson, L E Hernandez, R A Nelson, K C Marsh, B F Cox and S W Mittelstadt

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.206

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      Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model (pages 1446–1456)

      X Yao, D L Anderson, S A Ross, D G Lang, B Z Desai, D C Cooper, P Wheelan, M S McIntyre, M L Bergquist, K I MacKenzie, J D Becherer and M A Hashim

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.267

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      The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys (pages 1457–1464)

      T M Haushalter, G S Friedrichs, D L Reynolds, M Barecki-Roach, G Pastino, R Hayes and A S Bass

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.275

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      Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone (pages 1465–1473)

      M J Forrest, D Bloomfield, R J Briscoe, P N Brown, A-M Cumiskey, J Ehrhart, J C Hershey, W J Keller, X Ma, H E McPherson, E Messina, L B Peterson, W Sharif-Rodriguez, P K S Siegl, P J Sinclair, C P Sparrow, A S Stevenson, S-Y Sun, C Tsai, H Vargas, M Walker III, S H West, V White and R F Woltmann

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.229

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      The effect of changes in core body temperature on the QT interval in beagle dogs: a previously ignored phenomenon, with a method for correction (pages 1474–1481)

      H J Van Der Linde, B Van Deuren, A Teisman, R Towart and D J Gallacher

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.265

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      Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres (pages 1482–1490)

      K Sakamoto, H Mikami and J Kimura

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.192

  4. Themed Section Commentary

    1. Top of page
    2. Commentary
    3. Reviews
    4. Research Papers
    5. Themed Section Commentary
    6. Themed Section Reviews
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      International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes (pages 1491–1501)

      A S Bass, B Darpo, A Breidenbach, K Bruse, H S Feldman, D Garnes, T Hammond, W Haverkamp, C January, J Koerner, C Lawrence, D Leishman, D Roden, J P Valentin, M A Vos, Y-Y Zhou, T Karluss and P Sager

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.279

  5. Themed Section Reviews

    1. Top of page
    2. Commentary
    3. Reviews
    4. Research Papers
    5. Themed Section Commentary
    6. Themed Section Reviews
    1. You have full text access to this OnlineOpen article
      Cellular basis of drug-induced torsades de pointes (pages 1502–1507)

      D M Roden

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.238

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      The impact of varying autonomic states on the dynamic beat-to-beat QT–RR and QT–TQ interval relationships (pages 1508–1515)

      A A Fossa

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.123

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      In vitro models of proarrhythmia (pages 1516–1522)

      C L Lawrence, C E Pollard, T G Hammond and J-P Valentin

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.195

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      Literature-based evaluation of four ‘hard endpoint’ models for assessing drug-induced torsades de pointes liability (pages 1523–1527)

      M A Vos

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.277

    5. You have full text access to this OnlineOpen article
      Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts (pages 1528–1537)

      A Sugiyama

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.240

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      Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective (pages 1538–1543)

      C E Pollard, J-P Valentin and T G Hammond

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.203

    7. You have full text access to this OnlineOpen article
      Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes (pages 1544–1549)

      P T Sager

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.222

    8. You have full text access to this OnlineOpen article
      Moving towards better predictors of drug-induced torsades de pointes (pages 1550–1553)

      A S Bass, B Darpo, J-P Valentin, P Sager and K Thomas

      Article first published online: 29 JAN 2009 | DOI: 10.1038/bjp.2008.215

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