British Journal of Pharmacology

© The British Pharmacological Society

Cover image for Vol. 165 Issue 5

March 2012

Volume 165, Issue 5

Pages 1217–1608

  1. EDITORIAL

    1. Top of page
    2. EDITORIAL
    3. REVIEW WITH COMMENTARY
    4. REVIEWS
    5. RESEARCH PAPERS WITH COMMENTARIES
    6. RESEARCH PAPERS
    1. You have free access to this content
      Different tests for a difference: how do we do research? (pages 1217–1222)

      Gordon B Drummond and Sarah L Vowler

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01809.x

  2. REVIEW WITH COMMENTARY

    1. Top of page
    2. EDITORIAL
    3. REVIEW WITH COMMENTARY
    4. REVIEWS
    5. RESEARCH PAPERS WITH COMMENTARIES
    6. RESEARCH PAPERS
    1. You have free access to this content
      What makes the α1A-adrenoceptor gene express the α1L-adrenoceptor functional phenotype? (pages 1223–1225)

      S Ventura

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01663.x

    2. Phenotype pharmacology of lower urinary tract α1-adrenoceptors (pages 1226–1234)

      A Nishimune, H Yoshiki, J Uwada, ASM Anisuzzaman, H Umada and I Muramatsu

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01591.x

  3. REVIEWS

    1. Top of page
    2. EDITORIAL
    3. REVIEW WITH COMMENTARY
    4. REVIEWS
    5. RESEARCH PAPERS WITH COMMENTARIES
    6. RESEARCH PAPERS
    1. Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent (pages 1235–1245)

      DJ Hausenloy, EA Boston-Griffiths and DM Yellon

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01700.x

    2. Tau-targeted treatment strategies in Alzheimer's disease (pages 1246–1259)

      Jürgen Götz, Arne Ittner and Lars M Ittner

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01713.x

    3. OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies (pages 1260–1287)

      Megan Roth, Amanda Obaidat and Bruno Hagenbuch

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01724.x

    4. Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments (pages 1288–1305)

      Thérèse Keravis and Claire Lugnier

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01729.x

    5. The evolving science of detection of ‘blood doping’ (pages 1306–1315)

      Carsten Lundby, Paul Robach and Bengt Saltin

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01822.x

  4. RESEARCH PAPERS WITH COMMENTARIES

    1. Top of page
    2. EDITORIAL
    3. REVIEW WITH COMMENTARY
    4. REVIEWS
    5. RESEARCH PAPERS WITH COMMENTARIES
    6. RESEARCH PAPERS
    1. You have free access to this content
      TLR4-MyD88 signalling: a molecular target for alcohol actions (pages 1316–1318)

      Subhash C Pandey

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01695.x

    2. Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice (pages 1319–1329)

      Yue Wu, Erin L Lousberg, Lachlan M Moldenhauer, John D Hayball, Janet K Coller, Kenner C Rice, Linda R Watkins, Andrew A Somogyi and Mark R Hutchinson

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01572.x

    3. You have free access to this content
      Endothelin and bradykinin: ‘brothers-in-arms’ in Chagas vasculopathies? (pages 1330–1332)

      Pedro D'Orléans-Juste, Ghassan Bkaily and Giles Alexander Rae

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01636.x

    4. Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy (pages 1333–1347)

      Daniele Andrade, Rafaela Serra, Erik Svensjö, Ana Paula C Lima, Erivan S Ramos Junior, Fabio S Fortes, Ana Carolina F Morandini, Verônica Morandi, Maria de N Soeiro, Herbert B Tanowitz and Julio Scharfstein

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01609.x

  5. RESEARCH PAPERS

    1. Top of page
    2. EDITORIAL
    3. REVIEW WITH COMMENTARY
    4. REVIEWS
    5. RESEARCH PAPERS WITH COMMENTARIES
    6. RESEARCH PAPERS
    1. Azithromycin distinctively modulates classical activation of human monocytes in vitro (pages 1348–1360)

      M Vrančić, M Banjanac, K Nujić, M Bosnar, T Murati, V Munić, D Stupin Polančec, D Belamarić, MJ Parnham and V Eraković Haber

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01576.x

    2. Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis (pages 1361–1374)

      J Massart, MA Robin, F Noury, A Fautrel, P Lettéron, A Bado, PA Eliat and B Fromenty

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01580.x

    3. Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise (pages 1375–1389)

      Thibault Renoir, Terence YC Pang, Michelle S Zajac, Grace Chan, Xin Du, Leah Leang, Caroline Chevarin, Laurence Lanfumey and Anthony J Hannan

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01567.x

    4. Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a Mas receptor-dependent pathway (pages 1390–1400)

      Saghir Akhtar, Mariam HM Yousif, Gursev S Dhaunsi, Bindu Chandrasekhar, Omama Al-Farsi and Ibrahim F Benter

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01613.x

    5. Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys (pages 1401–1412)

      A Ulu, SE Appt, C Morisseau, SH Hwang, PD Jones, TE Rose, H Dong, J Lango, J Yang, HJ Tsai, C Miyabe, C Fortenbach, MR Adams and BD Hammock

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01641.x

    6. Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110) (pages 1413–1423)

      JY Suen, GD Barry, RJ Lohman, MA Halili, AJ Cotterell, GT Le and DP Fairlie

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01610.x

    7. Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment (pages 1424–1441)

      Yama A Abassi, Biao Xi, Nan Li, Wei Ouyang, Alexander Seiler, Manfred Watzele, Ralf Kettenhofen, Heribert Bohlen, Andreas Ehlich, Eugen Kolossov, Xiaobo Wang and Xiao Xu

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01623.x

    8. β2-Adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail (pages 1442–1456)

      Nodi Dehvari, Dana S Hutchinson, Julia Nevzorova, Olof S Dallner, Masaaki Sato, Martina Kocan, Jon Merlin, Bronwyn A Evans, Roger J Summers and Tore Bengtsson

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01647.x

    9. Long-term treatment with ivabradine in post-myocardial infarcted rats counteracts f-channel overexpression (pages 1457–1466)

      S Suffredini, F Stillitano, L Comini, M Bouly, S Brogioni, C Ceconi, R Ferrari, A Mugelli and E Cerbai

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01627.x

    10. TASK1 (K2P3.1) K+ channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation (pages 1467–1475)

      C Seyler, E Duthil-Straub, E Zitron, J Gierten, EP Scholz, RHA Fink, CA Karle, R Becker, HA Katus and D Thomas

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01626.x

    11. Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate (pages 1476–1486)

      Kenji Shintaku, Kunitoshi Uchida, Yoshiro Suzuki, Yiming Zhou, Tohru Fushiki, Tatsuo Watanabe, Susumu Yazawa and Makoto Tominaga

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01634.x

    12. Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase (pages 1487–1500)

      F Moroni, A Cozzi, A Chiarugi, L Formentini, E Camaioni, DE Pellegrini-Giampietro, Y Chen, S Liang, MM Zaleska, C Gonzales, A Wood and R Pellicciari

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01666.x

    13. Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma (pages 1501–1514)

      KS Buels, DB Jacoby and AD Fryer

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01632.x

    14. 5-HT receptors as novel targets for optimizing pigmentary responses in dorsal skin melanophores of frog, Hoplobatrachus tigerinus (pages 1515–1525)

      Sharique A Ali, Saima Salim, Tarandeep Sahni, Jaya Peter and Ayesha S Ali

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01630.x

    15. A naturally occurring naringenin derivative exerts potent bone anabolic effects by mimicking oestrogen action on osteoblasts (pages 1526–1542)

      Gaurav Swarnkar, Kunal Sharan, Jawed A Siddiqui, Jay Sharan Mishra, Kainat Khan, Mohd Parvez Khan, Varsha Gupta, Preeti Rawat, Rakesh Maurya, Anil K Dwivedi, Sabyasachi Sanyal and Naibedya Chattopadhyay

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01637.x

    16. Clozapine, but not haloperidol, enhances glial d-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes (pages 1543–1555)

      Shunske Tanahashi, Satoshi Yamamura, Masanori Nakagawa, Eishi Motomura and Motohiro Okada

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01638.x

    17. Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice (pages 1556–1571)

      M Bashashati, MA Storr, SP Nikas, JT Wood, G Godlewski, J Liu, W Ho, CM Keenan, H Zhang, SO Alapafuja, BF Cravatt, B Lutz, K Mackie, G Kunos, KD Patel, A Makriyannis, JS Davison and KA Sharkey

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01644.x

    18. A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes (pages 1572–1583)

      M Mezler, S Barghorn, H Schoemaker, G Gross and V Nimmrich

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01646.x

    19. TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ (pages 1584–1594)

      EJ Jang, H Jeong, JO Kang, NJ Kim, MS Kim, SH Choi, SE Yoo, JH Hong, MA Bae and ES Hwang

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01664.x

    20. Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor (pages 1595–1608)

      E Hoffart, L Ghebreghiorghis, AK Nussler, WE Thasler, TS Weiss, M Schwab and O Burk

      Article first published online: 10 FEB 2012 | DOI: 10.1111/j.1476-5381.2011.01665.x

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