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Brain and Behavior

Cover image for Vol. 2 Issue 1

January 2012

Volume 2, Issue 1

Pages i–i, 1–83

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Original Research
    1. You have full text access to this OnlineOpen article
      Issue Information (page i)

      Article first published online: 30 JAN 2012 | DOI: 10.1002/brb3.42

  2. Original Research

    1. Top of page
    2. Issue Information
    3. Original Research
    1. You have full text access to this OnlineOpen article
      Neuroimaging features of xeroderma pigmentosum group A (pages 1–5)

      Takehiro Ueda, Fumio Kanda, Nobukazu Aoyama, Masahiko Fujii, Chikako Nishigori and Tatsushi Toda

      Article first published online: 28 OCT 2011 | DOI: 10.1002/brb3.22

      Thumbnail image of graphical abstract

      Xeroderma pigmentosum group A (XPA) is a hereditary dermatological disease in which hypersensitivity to ultraviolet radiation and various neurological symptoms are observed. In this study, to evaluate the degeneration occurring in the brain of XPA patients, neurological examinations by an established neurologist and 3-Tesla magnetic resonance imaging (MRI) were performed in 10 Japanese XPA patients.

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      Specialization and integration of brain responses to object recognition and location detection (pages 6–14)

      Mark R. Pennick and Rajesh K. Kana

      Article first published online: 29 NOV 2011 | DOI: 10.1002/brb3.27

      Thumbnail image of graphical abstract

      Xeroderma pigmentosum group A (XPA) is a hereditary dermatological disease in which hypersensitivity to ultraviolet radiation and various neurological symptoms are observed. In this study, to evaluate the degeneration occurring in the brain of XPA patients, neurological examinations by an established neurologist and 3-Tesla magnetic resonance imaging (MRI) were performed in 10 Japanese XPA patients.

    3. You have full text access to this OnlineOpen article
      Executive deficits detected in mild Alzheimer's disease using the antisaccade task (pages 15–21)

      Liam D. Kaufman, Jay Pratt, Brian Levine and Sandra E. Black

      Article first published online: 7 DEC 2011 | DOI: 10.1002/brb3.28

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      The antisaccade task, a hands- and language-free metric, may provide a functional index of the Dorsolateral Prefrontal Cortex (DLPFC), a region damaged in the later stages of Alzheimer's Disease (AD). Our findings indicate that antisaccade impairments exist in mild AD, suggesting clinically detectable DLPFC pathology may be present earlier than suggested by previous studies.

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      Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice (pages 22–31)

      Jana P. Lim, Mimi E. Zou, Patricia H. Janak and Robert O. Messing

      Article first published online: 6 JAN 2012 | DOI: 10.1002/brb3.29

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      Although genetic background alters responses to ethanol, there has not yet been a methodical quantification of differences in ethanol-related behaviors between inbred and hybrid mice commonly used in gene targeting studies. Here, we compared C57BL/6NTac x 129S6/SvEvTac F1 hybrid mice (B6129S6) with C57BL/6NTac inbred mice (B6NT), and C57BL/6J x 129X1/SvJ F1 (B6129X1) and C57BL/6J x 129S4/SvJae F1 hybrids (B6129S4) with C57BL/6J mice (B6J), in five commonly used tests: continuous access 2-bottle choice drinking, intermittent limited-access binge drinking, ethanol clearance, ethanol-induced loss of the righting reflex, and conditioned place preference for ethanol. Our findings indicate that it may not be necessary to backcross hybrids to an inbred B6 background to study many ethanol-related behaviors in gene-targeted mice.

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      Beyond vascularization: aerobic fitness is associated with N-acetylaspartate and working memory (pages 32–41)

      Kirk I. Erickson, Andrea M. Weinstein, Bradley P. Sutton, Ruchika Shaurya Prakash, Michelle W. Voss, Laura Chaddock, Amanda N. Szabo, Emily L. Mailey, Siobhan M. White, Thomas R. Wojcicki, Edward McAuley and Arthur F. Kramer

      Article first published online: 9 JAN 2012 | DOI: 10.1002/brb3.30

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      We find that the effect of fitness on the human brain extends beyond vascularization; aerobic fitness is associated with neuronal viability in the frontal cortex of older adults.

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      Computational fluid dynamic characterization of carotid bifurcation stenosis in patient-based geometries (pages 42–52)

      Clemens M. Schirmer and Adel M. Malek

      Article first published online: 13 JAN 2012 | DOI: 10.1002/brb3.25

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      Hemodynamic forces play a role in determining endothelial cell (EC) phenotype and influence vascular remodeling. We present a lesion-based computational fluid dynamic (CFD) pilot analysis to understand the complex spatial and temporal hemodynamic changes that prevail in patients with high-grade carotid artery stenosis (CS). High-resolution three-dimensional (3D) rotational angiography datasets were acquired in eight patients, and used to generate computational meshes. CFD analysis was carried out implementing realistic shear-dependent viscosity for blood.

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      Neuron-oligodendrocyte myelination co-culture derived from embryonic rat spinal cord and cerebral cortex (pages 53–67)

      Yi Pang, Baoying Zheng, Simpson L. Kimberly, Zhengwei Cai, Philip G. Rhodes and Rick C. S. Lin

      Article first published online: 30 JAN 2012 | DOI: 10.1002/brb3.33

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      In this paper, we describe a simple and reproducible myelination culture method using dissociated neuron-oligodendrocyte co-cultures from embryonic rat spinal cord or cerebral cortex. We further showed that this in vitro model can be a useful tool for myelin deficit investigation.

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      Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation (pages 68–73)

      Toru Kono, Machiko Satomi, Manabu Suno, Norihisa Kimura, Hirotaka Yamazaki, Hiroyuki Furukawa and Kazuo Matsubara

      Article first published online: 30 JAN 2012 | DOI: 10.1002/brb3.34

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      Role of transient receptor potential melastatin 8 (TRPM8) as a mediator of oxaliplatin cold hypersensitivity using menthol.

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      Verbal and facial-emotional Stroop tasks reveal specific attentional interferences in sad mood (pages 74–83)

      Linda Isaac, Janna N. Vrijsen, Paul Eling, Iris van Oostrom, Anne Speckens and Eni S. Becker

      Article first published online: 30 JAN 2012 | DOI: 10.1002/brb3.38

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      Attentional interference for mood-congruent depressive words and threat-related angry facial expressions have significant influences on attentional processes among people in a sad mood state.

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