Longitudinal brain activity changes in asymptomatic Alzheimer disease (pages 221–230)
Kari-Elise T. Codispoti, Lori L. Beason-Held, Michael A. Kraut, Richard J. O’Brien, Gay Rudow, Olga Pletnikova, Barbara Crain, Juan C. Troncoso and Susan M. Resnick
Article first published online: 20 MAR 2012 | DOI: 10.1002/brb3.47
This study is based on PET and autopsy data collected in the Baltimore Longitudinal Study of Aging. We describe changes in brain function that occur over a 7 year period in older individuals who are cognitively normal during the PET scanning period, but subsequently go on to receive differential diagnoses at autopsy. Differences in brain activation patterns are presented for those with Asymptomatic Alzheimer disease (normal cognition despite substantial Alzheimer disease pathology) and those with cognitive impairment and Alzheimer pathology relative to cognitively and pathologically normal individuals.