• Open Access

Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma

Authors

  • Xiao-Hong Guo,

    1. Center for Salivary Gland Diseases of Peking University School and Hospital of Stomatology, Department of Physiology and Pathophysiology, Peking University Health Science Center and Key Laboratory of Molecular Cardiovascular Sciences, Beijing, China
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  • Jin-Yu Wang,

    1. Center for Salivary Gland Diseases of Peking University School and Hospital of Stomatology, Department of Physiology and Pathophysiology, Peking University Health Science Center and Key Laboratory of Molecular Cardiovascular Sciences, Beijing, China
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  • Yan Gao,

    1. Department of Oral Pathology, Peking University School and Hospital of Stomatology, Beijing, China
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  • Min Gao,

    1. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China
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  • Guang-Yan Yu,

    1. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China
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  • Ruo-Lan Xiang,

    1. Center for Salivary Gland Diseases of Peking University School and Hospital of Stomatology, Department of Physiology and Pathophysiology, Peking University Health Science Center and Key Laboratory of Molecular Cardiovascular Sciences, Beijing, China
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  • Li Li,

    1. Center for Salivary Gland Diseases of Peking University School and Hospital of Stomatology, Department of Physiology and Pathophysiology, Peking University Health Science Center and Key Laboratory of Molecular Cardiovascular Sciences, Beijing, China
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  • Ning-Yan Yang,

    1. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China
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  • Xin Cong,

    1. Center for Salivary Gland Diseases of Peking University School and Hospital of Stomatology, Department of Physiology and Pathophysiology, Peking University Health Science Center and Key Laboratory of Molecular Cardiovascular Sciences, Beijing, China
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  • Xiao-Yan Xu,

    1. Department of Pathology, Peking University Health Science Center, Beijing, China
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  • Sheng-Lin Li,

    1. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China
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  • Xin Peng,

    Corresponding author
    1. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China
    • Center for Salivary Gland Diseases of Peking University School and Hospital of Stomatology, Department of Physiology and Pathophysiology, Peking University Health Science Center and Key Laboratory of Molecular Cardiovascular Sciences, Beijing, China
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  • Li-Ling Wu

    Corresponding author
    • Center for Salivary Gland Diseases of Peking University School and Hospital of Stomatology, Department of Physiology and Pathophysiology, Peking University Health Science Center and Key Laboratory of Molecular Cardiovascular Sciences, Beijing, China
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To whom correspondence should be addressed.

E-mails: pathophy@bjmu.edu.cn; pxpengxin@263.net

Abstract

Circulating adiponectin levels are inversely associated with risk of various obesity-related cancers. However, the effect of adiponectin on carcinogenesis and progression of tongue squamous cell carcinoma (TSCC) remains unknown. We measured serum adiponectin levels in 59 patients with TSCC and 50 healthy controls. Expression of adiponectin and its receptors in paired tumor and paracancerous specimens were determined by immunohistochemical staining (= 37) and western blot (= 30), respectively. Serum adiponectin level was lower in patients than in controls (5.0 ± 2.4 vs 8.4 ± 3.5 μg/mL, P < 0.01), and was inversely associated with histological grade and lymph node metastasis but not tumor size. Local adiponectin levels in tumor tissue gradually decreased as tumor-node-metastasis stage increased, while the expression of adiponectin receptors was unchanged. In addition, serum adiponectin levels in the TSCC patients without metabolic and cardiovascular diseases, or without smoking and drinking habits, were still lower than in controls. Furthermore, adiponectin inhibited the migration, but not proliferation, of SCC15 cells in vitro. These results indicate that a decreased adiponectin level is associated with risk of TSCC. Hypoadiponectinemia might be used as a biomarker to predict an aggressive phenotype of TSCC.

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