• Open Access

Urinary tract infection increases subsequent urinary tract cancer risk: A population-based cohort study

Authors

  • Li-Min Sun,

    1. Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan
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    • These authors contributed equally to this work.
  • Cheng-Li Lin,

    1. Institute of Public Health, College of Public Health, China Medical University, Taichung, Taiwan
    2. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
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  • Ji-An Liang,

    1. Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
    2. Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan
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    • These authors contributed equally to this work.
  • Shu-Hui Liu,

    1. Institute of Public Health, College of Public Health, China Medical University, Taichung, Taiwan
    2. Department of Health Care and Social Work, Yu Da University, Miaoli, Taiwan
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  • Fung-Chang Sung,

    1. Institute of Public Health, College of Public Health, China Medical University, Taichung, Taiwan
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  • Yen-Jung Chang,

    Corresponding author
    1. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan
    2. Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
    • Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan
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  • Chia-Hung Kao

    Corresponding author
    1. Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan
    2. Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan
    • Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan
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To whom correspondence should be addressed.

E-mail: d10040@mail.cmuh.org.tw

Abstract

This study examines the possible association between urinary tract infection (UTI) and urinary tract cancer (UTC). Data from the National Health Insurance system of Taiwan were used for the analysis. The UTI cohort included 70 116 patients who were diagnosed and recruited between 1997 and 2010. Each patient was randomly frequency-matched with two people without UTI from the general population based on their age, sex, and month of UTI diagnosis. Cox's proportional hazard regression analysis was used to estimate the effects of UTI on UTC risk until the end of follow-up on December 31, 2010. Patients with UTI had a significantly higher risk of developing UTC than healthy people (adjusted hazard ratio, 4.66; 95% confidence interval, 3.55–6.10). Further analyses indicated that risks are potentially related to the level of the lesion site. This study indicated that patients with UTI had a higher risk of developing UTC.

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