These authors contributed equally to this work.
Urinary tract infection increases subsequent urinary tract cancer risk: A population-based cohort study
Article first published online: 26 MAR 2013
© 2013 Japanese Cancer Association
Volume 104, Issue 5, pages 619–623, May 2013
How to Cite
(Cancer Sci 2013; 104: 619–623)
- Issue published online: 15 APR 2013
- Article first published online: 26 MAR 2013
- Accepted manuscript online: 14 FEB 2013 01:38AM EST
- Manuscript Accepted: 7 FEB 2013
- Manuscript Revised: 3 FEB 2013
- Manuscript Received: 9 JAN 2013
- Taiwan Department of Health Clinical Trial and Research Center
- Taiwan Department of Health Cancer Research Center for Excellence. Grant Number: DOH102-TD-C-111-005
This study examines the possible association between urinary tract infection (UTI) and urinary tract cancer (UTC). Data from the National Health Insurance system of Taiwan were used for the analysis. The UTI cohort included 70 116 patients who were diagnosed and recruited between 1997 and 2010. Each patient was randomly frequency-matched with two people without UTI from the general population based on their age, sex, and month of UTI diagnosis. Cox's proportional hazard regression analysis was used to estimate the effects of UTI on UTC risk until the end of follow-up on December 31, 2010. Patients with UTI had a significantly higher risk of developing UTC than healthy people (adjusted hazard ratio, 4.66; 95% confidence interval, 3.55–6.10). Further analyses indicated that risks are potentially related to the level of the lesion site. This study indicated that patients with UTI had a higher risk of developing UTC.