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cas12175-sup-0001-DataS1-FigS1-S11.docxWord document1640K

Data S1. Materials and methods.

Fig. S1. The absence of the known driver mutations.

Fig. S2. Suppression of RET mRNA in siRET-treated cells.

Fig. S3. RET-dependent transcriptome profile in LC-2/ad cells.

Fig. S4. Dose-dependent effect of vandetanib in PC-9 cells.

Fig. S5. WST-8 assay with various kinase inhibitors.

Fig. S6. Effect of sunitinib and sorafenib on G1 phase population of LC-2/ad cells.

Fig. S7. Effect of sunitinib and sorafenib on apoptosis of LC-2/ad cells.

Fig. S8. Dose-dependent effect of AZD6244 and BEZ235 in LC-2/ad cells.

Fig. S9. WST-8 assay of LC-2/ad cells treated with AZD6244 and BEZ235.

Fig. S10. Body weight of the vandetanib-, sunitinib-, sorafenib- and vehicle-treated mice.

Fig. S11. Effect of sunitinib and sorafenib in vivo.

cas12175-sup-0002-TableS1.docxWord document21KTable S1. Polymerase chain reaction primers.
cas12175-sup-0003-TableS2.xlsapplication/msexcel292KTable S2. Summary of the microarray data.

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