In 2013, the Japan Diabetes Society established The Japan Diabetes Society/Japanese Cancer Association (JDS/JCA) Joint Committee on Diabetes and Cancer, which published the final committee report in J Japan Diab Soc 2013; 56: 374–90 (in Japanese).1 This is the English language translation of that report published in the official journal of the JDS, Diabetology International, in 2013, and has been jointly published in Cancer Science and Diabetology International by The Japanese Cancer Association and The Japan Diabetes Society.
Report of the Japan Diabetes Society/Japanese Cancer Association joint committee on diabetes and cancer
Version of Record online: 24 JUL 2013
© 2013 The Japanese Cancer Association and the Japan Diabetes Society
Volume 104, Issue 7, pages 965–976, July 2013
How to Cite
(Cancer Sci 2013; 104: 965–976)
Members of the Japan Diabetes Society/Japanese Cancer Association Joint Committee on Diabetes and Cancer. Japan Diabetes Society (JDS): Masato Kasuga, Kohjiro Ueki, Naoko Tajima, Mitsuhiko Noda, and Ken Ohashi. Editorial assistants: Hiroshi Noto, Atsushi Goto, and Wataru Ogawa Japanese Cancer Association (JCA): Ryuichi Sakai, Shoichiro Tsugane, Nobuyuki Hamajima, Hitoshi Nakagama, Kazuo Tajima, Kohei Miyazono, and Kohzoh Imai.
- Issue online: 24 JUL 2013
- Version of Record online: 24 JUL 2013
- Manuscript Accepted: 12 MAY 2013
- Manuscript Received: 10 MAY 2013
In recent years, diabetes has been shown to be associated with cancer risk, and this has led to a joint committee being formed, enlisting experts from the Japan Diabetes Society and the Japanese Cancer Association to address this issue. Epidemiological data in Japan provides evidence to demonstrate that diabetes is associated with increased risk for cancers, especially colorectal, liver, and pancreatic cancers. The mechanisms through which diabetes is assumed to promote oncogenesis include insulin resistance and associated hyperinsulinemia, hyperglycemia, and inflammation. Common risk factors for type 2 diabetes and cancer include aging, male sex, obesity, physical inactivity, inappropriate diet (excessive red/processed meat intake, inadequate vegetable/fruit/dietary fiber intake), excessive alcohol drinking, and smoking. Given that inappropriate diet/exercise, smoking and excessive alcohol drinking are common risk factors for diabetes and cancer, diet/exercise therapy, smoking cessation and alcohol moderation may be associated with decreased risk for cancer in diabetic patients. There is as yet limited evidence as to whether any particular antidiabetic agents may influence cancer risk.