• Open Access

P16INK4A as a surrogate biomarker for human papillomavirus-associated oropharyngeal carcinoma: Consideration of some aspects

Authors

  • Hongzhi Wang,

    1. Sun Yat-sen University Cancer Center, Guangdong, China
    2. State Key Laboratory of Oncology in South China, Guangdong, China
    3. Collaborative Innovation Center for Cancer Medicine, Guangdong, China
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  • Rui Sun,

    1. Sun Yat-sen University Cancer Center, Guangdong, China
    2. State Key Laboratory of Oncology in South China, Guangdong, China
    3. Collaborative Innovation Center for Cancer Medicine, Guangdong, China
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  • Hui Lin,

    1. Guangdong General Hospital, Guangdong, China
    2. Guangdong Academy of Medical Sciences, Guangdong, China
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  • Wei-han Hu

    Corresponding author
    1. Sun Yat-sen University Cancer Center, Guangdong, China
    2. State Key Laboratory of Oncology in South China, Guangdong, China
    3. Collaborative Innovation Center for Cancer Medicine, Guangdong, China
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Abstract

Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCCs) frequently show different clinical and pathological features, which tend to be younger age, better performance status, less tobacco and alcohol consumption, more poorly differentiated histopathology, but usually with better treatment response and prognosis compared with HPV-negative OPSCCs. In tumor tissue, HPV infection is closely correlated with p16INK4A expression, which has been suggested to be a surrogate biomarker of HPV infection. However, there is diversity of sensitivity and specificity about p16INK4A in surrogate detection of HPV status. Herein, we summarize the current knowledge and note some aspects for consideration concerning p16INK4A as a surrogate biomarker for HPV-associated OPSCC.

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