• 1
    Kotsakis A, Yousem S, Gadgeel SM. Is histologic subtype significant in the management of NSCLC ? Open Lung Cancer J 2010; 3: 6672.
  • 2
    Yakut T, Schulten HJ, Demir A et al. Assessment of molecular events in squamous and non-squamous cell lung carcinoma. Lung Cancer 2006; 54: 293301.
  • 3
    Cohen MH, Cortazar P, Justice R et al. Approval summary: pemetrexed maintenance therapy of advanced/metastatic nonsquamous, non-small cell lung cancer (NSCLC). Oncologist 2010; 15: 13528.
  • 4
    Reck M, Pawel JV, Zatloukal P et al. Manegold, Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. J Clin Oncol 2009; 27: 122734.
  • 5
    Scagliotti GV, Parikh P, Pawel JV et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008; 26: 354351.
  • 6
    Sandler A, Gray R, Perry MC et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. New Engl J Med 2006; 355: 254250.
  • 7
    Meuwissen R, Berns A. Mouse models for human lung cancer. Genes Dev 2005; 19: 64364.
  • 8
    Chen Z, Zhang Y, Yang J et al. Estrogen promotes benzo[a]pyrene-induced lung carcinogenesis through oxidative stress damage and cytochrome c-mediated caspase-3 activation pathways in female mice. Cancer Lett 2011; 308: 1422.
  • 9
    Mernitz H, Smith DE, Zhu AX et al. 9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2. Cancer Lett 2006; 244: 1018.
  • 10
    Mauderly JL, Gigliotti AP, Barr EB et al. Chronic inhalation exposure to mainstream cigarette smoke increases lung and nasal tumor incidence in rats. Toxicol Sci 2004; 81: 28092.
  • 11
    Yoshimoto T, Hirao F, Sakatani M et al. Induction of squamous cell carcinoma in the lung of C57BL/6 mice by intratracheal instillation of benzo[a]pyrene with charcoal powder. Gann 1977; 68: 34352.
  • 12
    Yoshimoto T, Inoue T, Iizuka H et al. Differential induction of squamous cell carcinomas and adenocarcinomas in mouse lung by intratracheal instillation of benzo(a)pyrene and charcoal powder. Cancer Res 1980; 40: 43017.
  • 13
    Rehm S, Lijinsky W, Singh G et al. Mouse bronchiolar cell carcinogenesis. Histologic characterization and expression of clara cell antigen in lesions induced by N-nitrosobis-(2-chloroethyl) ureas. Am J Pathol 1991; 139: 41322.
  • 14
    Singh SV, Benson PJ, Hu X et al. Gender-related differences in susceptibility of A/J mouse to benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis. Cancer Lett 1998; 128: 197204.
  • 15
    Wei M, Hamoud AS, Yamaguchi T et al. Potassium bromate enhances N-ethyl-N hydroxyethylnitrosamine-induced kidney carcinogenesis only at high doses in Wistar rats: indication of the existence of an enhancement threshold. Toxicol Pathol 2009; 37: 98391.
  • 16
    Renne R, Brix A, Harkema J et al. Proliferative and nonproliferative lesions of the rat and mouse respiratory tract. Toxicol Pathol 2009; 37: 5S73S.
  • 17
    Wakai K, Inoue M, Mizoue T et al. Tobacco smoking and lung cancer risk: an evaluation based on a systematic review of epidemiological evidence among the Japanese population. Jpn J Clin Oncol 2006; 36: 30924.
  • 18
    Funai K, Yokose T, Ishii G et al. Clinicopathologic characteristics of peripheral squamous cell carcinoma of the lung. Am J Surg Pathol 2003; 27: 97884.
  • 19
    Watanabe Y, Yokose T, Sakuma Y et al. Alveolar space filling ratio as a favorable prognostic factor in small peripheral squamous cell carcinoma of the lung. Lung Cancer 2011; 73: 21721.
  • 20
    Jetten AM, Nervi C, Vollberg TM et al. Control of squamous differentiation in tracheobronchial and epidermal epithelial cells: role of retinoids. J Natl Cancer Inst Monogr 1992; 13: 93100.
  • 21
    Sun W, Zhang K, Zhang X et al. Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization. Cancer Lett 2004; 212: 8393.
  • 22
    Debus E, Moll R, Franke WW et al. Immunohistochemical distinction of human carcinomas by cytokeratin typing with monoclonal antibodies. Am J Pathol 1984; 114: 12130.
  • 23
    Kargi A, Gurel D, Tuna B et al. The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas. Appl Immunohistochem Mol Morphol 2007; 15: 41520.
  • 24
    Liu W, Innocenti F, Chen P et al. Interethnic difference in the allelic distribution of human epidermal growth factor receptor intron 1 polymorphism. Clin Cancer Res 2003; 9: 100912.
  • 25
    Cragg MS, Kuroda J, Puthalakath H et al. Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med 2007; 4: e316.
  • 26
    Willmarth NE, Baillo A, Dziubinski ML et al. Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop. Cell Signal 2009; 21: 2129.
  • 27
    Half E, Sun Y, Sinicrope FA et al. Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells. Cancer Lett 2007; 251: 23746.
  • 28
    Morinaga R, Okamoto I, Fujita Y et al. Association of epidermal growth factor receptor (EGFR) gene mutations with EGFR amplification in advanced non-small cell lung cancer. Cancer Sci 2008; 99: 245560.
  • 29
    Paez JG, Janne PA, Lee JC et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 307: 1497500.
  • 30
    Skrzypski M, Jassem E, Taron M et al. Three-gene expression signature predicts survival in early-stage squamous cell carcinoma of the lung. Clin Cancer Res 2008; 14: 47949.
  • 31
    Hussenet T, Dali S, Exinger J et al. SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas. PLoS ONE 2010; 5: e8960.
  • 32
    Bass AJ, Watanabe H, Mermel CH et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 2009; 41: 123842.
  • 33
    Sasaki H, Hikosaka Y, Okuda Y et al. NFE2L2 gene mutation in male Japanese squamous cell carcinoma of the lung. J Thorac Oncol 2010; 5: 7869.
  • 34
    McDowell EM, Keenan KP, Huang M et al. Restoration of mucociliary tracheal epithelium following deprivation of vitamin A. A quantitative morphologic study. Virchows Arch B Cell Pathol Incl Mol Pathol 1984; 45: 22140.
  • 35
    Hong KU, Reynolds SD, Watkins S et al. Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. Am J Pathol 2004; 164: 57788.
  • 36
    Zhang XM, McDowell EM. Vitamin A deficiency and inflammation: the pivotal role of secretory cells in the development of atrophic, hyperplastic and metaplastic change in the tracheal epithelium in vivo. Virchows Arch B Cell Pathol Incl Mol Pathol 1992; 61: 37587.
  • 37
    Rehm S, Lijinsky W. Squamous metaplasia of bronchiolar cell-derived adenocarcinoma induced by N-nitrosomethyl-n-heptylamine in syrian hamsters. Vet Pathol 1994; 31: 56171.
  • 38
    Cui T, Chen Y, Yang L et al. Diagnostic and prognostic impact of desmocollins in human lung cancer. J Clin Pathol 2012; 65: 11006.
  • 39
    Wang Y, Zhang Z, Yan Y et al. A chemically induced model for squamous cell carcinoma of the lung in mice: histopathology and strain susceptibility. Cancer Res 2004; 64: 164754.
  • 40
    Hudish TM, Opincariu LI, Mozer AB et al. N-nitroso-tris-chloroethylurea induces premalignant squamous dysplasia in mice. Cancer Prev Res (Phila) 2012; 5: 2839.
  • 41
    Stellman SD, Muscat JE, Hoffmann D et al. Impact of filter cigarette smoking on lung cancer histology. Prev Med 1997; 26: 4516.
  • 42
    Huang RY, Li MY, Hsin MK et al. 4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor. Oncogene 2011; 30: 10616.
  • 43
    West KA, Brognard J, Clark AS et al. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J Clin Invest 2003; 111: 8190.
  • 44
    Hung YH, Hung WC. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) enhances invasiveness of lung cancer cells by up-regulating contactin-1 via the alpha7 nicotinic acetylcholine receptor/ERK signaling pathway. Chem Biol Interact 2009; 179: 1549.
  • 45
    Wang Y, Zhang Z, Garbow JR et al. Chemoprevention of lung squamous cell carcinoma in mice by a mixture of Chinese herbs. Cancer Prev Res (Phila) 2009; 2: 63440.
  • 46
    Seranno SD, Meuwissen R. Progress and applications of mouse models for human lung cancer. Eur Respir J 2010; 35: 42643.
  • 47
    Doi K, Sakai K, Tanaka R et al. Chemopreventive effects of 13alpha, 14alpha-epoxy-3beta-methoxyserratan-21beta-ol (PJJ-34), a serratane-type triterpenoid, in a rat multi-organ carcinogenesis bioassay. Cancer Lett 2010; 289: 1619.
  • 48
    Doi K, Wanibuchi H, Salim EI et al. Revised rat multi-organ carcinogenesis bioassay for whole-body detection of chemopreventive agents: modifying potential of S-methylcysteine. Cancer Lett 2004; 206: 1526.
  • 49
    Khan N, Afaq F, Kweon MH et al. Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res 2007; 67: 347582.