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Fig. S1. Other inhibitors cannot block HRG1-mediated phosphorylation of HER3 and AKT.

Fig. S2. Other inhibitors cannot abrogate HRG1-mediated resistance.

Fig. S3. Trastuzumab cannot inhibit HRG1-mediated phosphorylation of HER3 and AKT and HRG1-mediated resistance to lapatinib.

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