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Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis

  1. Top of page
  2. Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis
  3. Paracrine activation of MET promotes peritoneal carcinomatosis in scirrhous gastric cancer
  4. In vivo delivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer
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Page 1711–7

In this exciting new study, Suzuki and colleagues investigated whether apocynin, a catecholamine, could suppress prostate carcinogenesis in a transgenic rat model. Working through the inhibition of the NADPH oxidase complex, a complex known to generate reactive oxygen species, apocynin downregulated cell proliferation and served to stall rapidly dividing cells in the G0 phase of cell division. Furthermore, apocynin showed no toxic effects on the rats. This evidence furthers the idea that prostate cancer is promoted and perhaps even induced by reactive oxygen species, and that non-toxic compounds such as apocynin could prove life-saving in those at risk of prostate cancer. doi: 10.1111/cas.12292

Paracrine activation of MET promotes peritoneal carcinomatosis in scirrhous gastric cancer

  1. Top of page
  2. Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis
  3. Paracrine activation of MET promotes peritoneal carcinomatosis in scirrhous gastric cancer
  4. In vivo delivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer
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Page 1640–6

The molecular mechanisms by which scirrhous gastric cancer efficiently produces peritoneal carcinomatosis with massive ascites are poorly understood. In this study, Zhao and colleagues investigated the possible role of the HGF-MET axis in the pathogenesis of peritoneal carcinomatosis caused by human gastric cancer. They demonstrated the critical role of the paracrine HGF in peritoneal carcinomatosis with massive ascites by scirrhous gastric cancer without MET amplification and the therapeutic potential of MET tyrosine kinase inhibitors (TKIs) using preclinical models. This breakthrough paper could serve not only as the basis for a better understanding of the pathogenesis of peritoneal carcinomatosis with malignant ascites, but also as a stepping stone for future researchers to develop targeted treatments for this lethal cancer. doi: 10.1111/cas.12301

In vivo delivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer

  1. Top of page
  2. Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis
  3. Paracrine activation of MET promotes peritoneal carcinomatosis in scirrhous gastric cancer
  4. In vivo delivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer
Thumbnail image of

Page 1705–10

Anti-angiogenesis is a well-established mechanism to impair tumor growth; clinical trials have shown the beneficial effects of inhibiting vascular formation in a variety of cancers. Ovarian cancer is one such malignancy, for which data suggests angiogenesis may be an effective target to improve clinical outcomes. In this article, Koyanagi and coworkers elaborate on prior work with vasohibin-2, an angiogenic stimulator. In a xenograft model of ovarian cancer, the authors used a sophisticated method for in vivo gene silencing with siRNA and an atelocollagen delivery system. Using this method, the siRNA could achieve a significant knockdown of the VASH2 gene, which the authors show is associated with inhibition of angiogenesis and tumor growth. This work is an important step toward developing additional tools to overcome tumor resistance. doi: 10.1111/cas.12297