Gist of Dr. Katsusaburo Yamagiwa's papers entitled “Experimental study on the pathogenesis of epithelial tumors” (I to VI reports)
Article first published online: 17 JAN 2014
© 2013 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Volume 105, Issue 2, pages 143–149, February 2014
How to Cite
Cancer Sci 105 (2014) 143–149
- Issue published online: 10 FEB 2014
- Article first published online: 17 JAN 2014
- Accepted manuscript online: 8 DEC 2013 10:02PM EST
- Manuscript Accepted: 4 DEC 2013
- Manuscript Revised: 2 DEC 2013
- Manuscript Received: 28 OCT 2013
- Carcinomatous medium;
- folliculoepithelioma papillosum;
- irritation theory;
- tar painting
The concept of cancer and inflammation has a long history. Virchow's irritation theory based on human cancer engendered the essential role of inflammation in carcinogenesis. Drs. Yamagiwa and Ichikawa first published a comprehensive paper entitled “Experimental study on the pathogenesis of epithelial tumors” (I report) in 1915 in German, and went on to publish five more reports (1915–1924) under the same title. They succeeded in demonstrating that inflammation is an important carcinogenic factor, and the mechanisms are now being investigated by numerous scientists all over the world. In order to introduce Yamagiwa's work to modern cancer researchers, the essentials of their six reports have been translated into English as a short review. Scientists' comments on Yamagiwa's contribution are attached by way of introduction.