Funding Information Ministry of Education, Culture, Sports, Science, and Technology, Japan.
5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation
Article first published online: 28 JAN 2014
© 2013 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Volume 105, Issue 3, pages 290–296, March 2014
How to Cite
Cancer Sci 105 (2014) 290–296
- Issue published online: 6 MAR 2014
- Article first published online: 28 JAN 2014
- Accepted manuscript online: 18 DEC 2013 01:08PM EST
- Manuscript Accepted: 14 DEC 2013
- Manuscript Revised: 12 DEC 2013
- Manuscript Received: 13 NOV 2013
- Ministry of Education, Culture, Sports, Science, and Technology, Japan
Fig. S1. The expression level of CysLT1 is upregulated by EGF stimulation in A431 cells.
Fig. S2. CysLT1 antagonist MK-571 and montelukast suppress the migration of A431 cells.
Fig. S3. CysLT1 signaling regulates expression levels of Tiam1 protein in TT cells and EC109 cells.
Fig. S4. BU-4664L and AA-861 suppress the mRNA level of Tiam1 in A431 cells.
Fig. S5. The treatment of LTB4 or LTC4 cannot induce cell migration in A431 cells.
Fig. S6. The inhibitory effect of AA-861 on cell migration of A431 cells is canceled by the addition of LTD4.
Data S1. Methods.
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