Increased risk of cancer in patients with early-onset cataracts: A nationwide population-based study
Article first published online: 11 MAR 2014
© 2014 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Volume 105, Issue 4, pages 431–436, April 2014
How to Cite
Cancer SciCancer Sci 105 (2014) 431–436
- Issue published online: 11 APR 2014
- Article first published online: 11 MAR 2014
- Accepted manuscript online: 23 JAN 2014 04:03AM EST
- Manuscript Accepted: 18 JAN 2014
- Manuscript Revised: 17 JAN 2014
- Manuscript Received: 19 OCT 2013
- National Sciences Council, Executive Yuan. Grant Number: SC99-2621-M-039-001
- China Medical University Hospital. Grant Number: 1MS1, DMR-103-065 and DMR-103-067
- Taiwan Department of Health Clinical Trial and Research Center for Excellence. Grant Number: DOH101-TD-B-111-004
- Cancer Research Center of Excellence. Grant Number: DOH101-TD-C-111-005
- cohort study;
- early-onset cataracts;
Early-onset cataracts are associated with insufficient antioxidative activity, and, therefore, a potential risk of cancer. This study investigated the risk of cancer after being diagnosed with early-onset cataracts. Retrospective claims data from the Taiwan National Health Insurance Research Database were analyzed. Study subjects were comprised of patients with early-onset cataracts, aged 20–55 years (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] code 366.00, 366.01, 366.02, 366.03, 366.04, 366.09, 366.17 and 366.18) and newly diagnosed between 1997 and 2010 (n = 1281), and a comparison cohort without the disease (n = 5124). Both cohorts were followed up until 2010 to estimate the incidences of cancer. We used the Poisson regression model to compare incidence rate ratios and the 95% confidence interval (CI). Cox proportional hazards regression was used to assess the hazard ratio (HR) of cancer associated with early-onset cataracts. The overall incidence rate of all cancers was 2.19-fold higher in the early-onset cataract cohort than in the comparison cohort (8.06 vs 3.68 per 1000 person-years) with an adjusted HR of 2.13 (95% CI = 1.48, 3.07). The site-specific analysis also showed a strong relationship, with adjusted HR of 3.24 ((95% CI = 1.30, 8.10) for head and neck cancer, 3.29 (95% CI 1.16, 9.31) for hepatoma and 3.19 (95% CI 1.34, 7.58) for breast cancer. The present study suggests that patients with early-onset cataracts are at an increased risk of being diagnosed with cancer in subsequent years.