Epigenetic dysregulation in glioma

Authors

  • Yutaka Kondo,

    Corresponding author
    1. Division of Epigenomics, Aichi Cancer Center Research Institute, Nagoya, Japan
    2. Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    • Correspondence

      Yutaka Kondo, Division of Epigenomics, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.

      Tel/Fax: +81-52-764-2994;

      E-mail: ykondo@aichi-cc.jp

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  • Keisuke Katsushima,

    1. Division of Epigenomics, Aichi Cancer Center Research Institute, Nagoya, Japan
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  • Fumiharu Ohka,

    1. Division of Epigenomics, Aichi Cancer Center Research Institute, Nagoya, Japan
    2. Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    3. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan
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  • Atsushi Natsume,

    1. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan
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  • Keiko Shinjo

    1. Division of Epigenomics, Aichi Cancer Center Research Institute, Nagoya, Japan
    2. Division of Molecular Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan
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Abstract

Given that treatment options for patients with glioblastoma are limited, much effort has been made to clarify the underlying mechanisms of gliomagenesis. Recent genome-wide genomic and epigenomic analyses have revealed that mutations in epigenetic modifiers occur frequently in gliomas and that dysregulation of epigenetic mechanisms is closely associated with glioma formation. Given that epigenetic changes are reversible, understanding the epigenetic abnormalities that arise in gliomagenesis might be key to developing more effective treatment strategies for glioma. In this review, we focus on the recent advancements in epigenetic research with respect to gliomas, consider how epigenetic mechanisms dynamically regulate tumor cells, including the cancer stem cell population, and discuss perspectives and challenges for glioma treatment in the near future.

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