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Cancer Science

Cover image for Vol. 104 Issue 12

December 2013

Volume 104, Issue 12

Pages December cover–December cover, i–iii, 1553–1730

  1. COVER IMAGE

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    2. COVER IMAGE
    3. PRELIMINARY PAGE
    4. IN THIS ISSUE
    5. REVIEW ARTICLE
    6. ORIGINAL ARTICLES
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  2. PRELIMINARY PAGE

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    2. COVER IMAGE
    3. PRELIMINARY PAGE
    4. IN THIS ISSUE
    5. REVIEW ARTICLE
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      Preliminary Page (pages i–ii)

      Version of Record online: 6 DEC 2013 | DOI: 10.1111/j.1349-7006.2013.02406.x

  3. IN THIS ISSUE

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      In This Issue (page iii)

      Version of Record online: 30 NOV 2013 | DOI: 10.1111/cas.12312

  4. REVIEW ARTICLE

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      P16INK4A as a surrogate biomarker for human papillomavirus-associated oropharyngeal carcinoma: Consideration of some aspects (pages 1553–1559)

      Hongzhi Wang, Rui Sun, Hui Lin and Wei-han Hu

      Version of Record online: 8 NOV 2013 | DOI: 10.1111/cas.12287

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      Human papillomavirus-associated oropharyngeal carcinomas have been extensively recognized a distinct entity. P16INK4A is evidenced to be a surrogate biomarker of HPV status. However, there is diversity of sensitivity and specificity about p16 in surrogate detection of HPV infection or transactivation. We summarized the current knowledge to explain the discrepancy between p16INK4A expression and HPV infection, and recommended suitable method of HPV status detection for clinical use. In addition, we reviewed the prognosis of p16INK4A or HPV associated entity and pointed out the cautious perspective for deintensified treatment.

  5. ORIGINAL ARTICLES

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    3. PRELIMINARY PAGE
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    1. CARCINOGENESIS

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      Novel medium-term carcinogenesis model for lung squamous cell carcinoma induced by N-nitroso-tris-chloroethylurea in mice (pages 1560–1566)

      Yoshiyuki Tago, Shotaro Yamano, Min Wei, Anna Kakehashi, Mitsuaki Kitano, Masaki Fujioka, Naomi Ishii and Hideki Wanibuchi

      Version of Record online: 24 NOV 2013 | DOI: 10.1111/cas.12289

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      We have established a new mouse model for lung SCC. Our findings indicated that the NTCU treatment duration-dependent increase in lung SCC is related to the up-regulation of cytokeratin 5/6 and EGFR expression.

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      Tumor-suppressive microRNA-143/145 cluster targets hexokinase-2 in renal cell carcinoma (pages 1567–1574)

      Hirofumi Yoshino, Hideki Enokida, Toshihiko Itesako, Satoko Kojima, Takashi Kinoshita, Shuichi Tatarano, Takeshi Chiyomaru, Masayuki Nakagawa and Naohiko Seki

      Version of Record online: 11 OCT 2013 | DOI: 10.1111/cas.12280

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      Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors (pages 1575–1585)

      Takehiro Suzuki, Satoshi Yamashita, Toshikazu Ushijima, Shota Takumi, Tomoharu Sano, Takehiro Michikawa and Keiko Nohara

      Version of Record online: 8 NOV 2013 | DOI: 10.1111/cas.12298

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      This study further revealed that the gene body region of the oncogene Fosb is highly methylated and its expression is greatly increased in the tumors of gestationally arsenic-exposed mice in comparison with the tumors of control mice. These results suggest that DNA methylation changes are involved in the alteration in tumor phenotype by gestational arsenic exposure.

    4. CELL, MOLECULAR, AND STEM CELL BIOLOGY

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      Involvement of homologous recombination in the synergism between cisplatin and poly (ADP-ribose) polymerase inhibition (pages 1593–1599)

      Kenji Sakogawa, Yoshiro Aoki, Keizo Misumi, Yoichi Hamai, Manabu Emi, Jun Hihara, Lin Shi, Kazuteru Kono, Yasunori Horikoshi, Jiying Sun, Tsuyoshi Ikura, Morihito Okada and Satoshi Tashiro

      Version of Record online: 10 OCT 2013 | DOI: 10.1111/cas.12281

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      B3GNT3 expression suppresses cell migration and invasion and predicts favorable outcomes in neuroblastoma (pages 1600–1608)

      Wan-Ling Ho, Mei-Ieng Che, Chih-Hsing Chou, Hsiu-Hao Chang, Yung-Ming Jeng, Wen-Ming Hsu, Kai-Hsin Lin and Min-Chuan Huang

      Version of Record online: 28 OCT 2013 | DOI: 10.1111/cas.12294

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      B3GNT3 expression suppresses cell migration and invasion and predicts favorable outcomes in neuroblastoma.

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      Hypoxia-induced downregulation of miR-30c promotes epithelial-mesenchymal transition in human renal cell carcinoma (pages 1609–1617)

      Jiwei Huang, Xiaoying Yao, Jin Zhang, Baijun Dong, Qi Chen, Wei Xue, Dongming Liu and Yiran Huang

      Version of Record online: 27 OCT 2013 | DOI: 10.1111/cas.12291

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      miR-30c was reported to be down-regulated in several types of cancer. However, its role in human renal cell carcinoma (RCC) remains largely unknown. Here, our findings propose a model that hypoxia induces EMT in RCC cells through down-regulation of miR-30c which leads to subsequent increase of Slug expression and repression of E-cadherin production, and suggest a potential application of miR-30c in RCC treatment.

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      Heregulin induces resistance to lapatinib-mediated growth inhibition of HER2-amplified cancer cells (pages 1618–1625)

      Yuji Sato, Masakazu Yashiro and Nobuyuki Takakura

      Version of Record online: 28 OCT 2013 | DOI: 10.1111/cas.12290

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      Here, we investigated whether and how HRG1 causes resistance to lapatinib in gastric and gastroesophageal junction cancers in vitro. Exposure to HRG1 together with lapatinib rescued cells from lapatinib-induced cell cycle arrest and apoptosis.

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      Plasma miR-21 is a novel diagnostic biomarker for biliary tract cancer (pages 1626–1631)

      Tomoya Kishimoto, Hidetoshi Eguchi, Hiroaki Nagano, Shogo Kobayashi, Hirofumi Akita, Naoki Hama, Hiroshi Wada, Koichi Kawamoto, Akira Tomokuni, Yoshito Tomimaru, Koji Umeshita, Yuichiro Doki and Masaki Mori

      Version of Record online: 12 NOV 2013 | DOI: 10.1111/cas.12300

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      In the present study, we evaluated the usefulness of plasma miR-21 as a diagnostic biomarker for biliary tract cancer (BTC). Judging solely by CA19-9 levels, many BTC patients were within the normal range. More BTC patients could be diagnosed by miR-21 levels. (Black circle, BTC patients; blue circle, HVs; red circle, BBD patients).

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      Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells (pages 1632–1639)

      Su-Hoon Lee, Mi-Ju Kim, Dong-Wan Kim, Chi-Dug Kang and Sun-Hee Kim

      Version of Record online: 12 NOV 2013 | DOI: 10.1111/cas.12299

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      Potentiation of TRAIL cytotoxicity of colon CSCs by amurensin G.

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      Paracrine activation of MET promotes peritoneal carcinomatosis in scirrhous gastric cancer (pages 1640–1646)

      Lu Zhao, Kazuo Yasumoto, Atsuhiro Kawashima, Takayuki Nakagawa, Shinji Takeuchi, Tadaaki Yamada, Kunio Matsumoto, Kazuhiko Yonekura, Osamu Yoshie and Seiji Yano

      Version of Record online: 13 NOV 2013 | DOI: 10.1111/cas.12301

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      We demonstrated the role of the paracrine HGF in peritoneal carcinomatosis with massive ascites produced in scirrhous gastric cancer, and the therapeutic potential of MET-TKIs by using preclinical models. Clinical trials of MET-TKIs for peritoneal carcinomatosis are therefore warranted to improve the prognosis of scirrhous gastric cancer.

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      Histone acetyltransferase Hbo1 destabilizes estrogen receptor α by ubiquitination and modulates proliferation of breast cancers (pages 1647–1655)

      Masayoshi Iizuka, Takao Susa, Yoshihisa Takahashi, Mimi Tamamori-Adachi, Takashi Kajitani, Hiroko Okinaga, Toshio Fukusato and Tomoki Okazaki

      Version of Record online: 25 NOV 2013 | DOI: 10.1111/cas.12303

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      Approximately two-thirds of breast cancers are dependent for proliferation and they respond to anti-hormone therapy. However, some breast cancers show resistance against anti-hormone therapy and recurrence occurs. The molecular mechanism of the resistance is largely unknown. Iizuka et al. uncovered a novel regulation of stability of estrogen receptor alpha, a central player for the estrogen-dependent growth of breast cancers. They found that DNA replication-associated histone acetyltransferase, Hbo1, promotes degradation of estrogen receptor alpha by ubiquitination.

    13. CLINICAL RESEARCH

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      Metabolic tumor volume by positron emission tomography/computed tomography as a clinical parameter to determine therapeutic modality for early stage Hodgkin's lymphoma (pages 1656–1661)

      Moo-Kon Song, Joo-Seop Chung, Je-Jung Lee, Shin Young Jeong, Sang-Min Lee, Jun-Shik Hong, Ari Chong, Joon-Ho Moon, Ji-Hyun Kim, Seok-Mo Lee, Seong Jang Kim and Ho-Jin Shin

      Version of Record online: 23 OCT 2013 | DOI: 10.1111/cas.12282

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      UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan (pages 1662–1669)

      Shoichi Hazama, Hideyuki Mishima, Ryouichi Tsunedomi, Yusuke Okuyama, Takeshi Kato, Ken-ichi Takahashi, Hiroshi Nozawa, Hideaki Ando, Michiya Kobayashi, Hiroyoshi Takemoto, Naoki Nagata, Shinsuke Kanekiyo, Yuka Inoue, Yoshihiko Hamamoto, Yusuke Fujita, Yuji Hinoda, Naoko Okayama, Koji Oba, Jun-ichi Sakamoto and Masaaki Oka

      Version of Record online: 27 OCT 2013 | DOI: 10.1111/cas.12283

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      The toxicities were significantly more frequent in patients with UGT1A1*6, UGT1A7 (387G), and UGT1A9*22 reference alleles (T9). Six out of 7 patients who were homozygous for UGT1A1*28 or *6 experienced severe hematological toxicity despite the fact that their response rate was not impaired (42.9%).

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      MIB-1 labeling index as a prognostic factor for patients with follicular lymphoma treated with rituximab plus CHOP therapy (pages 1670–1674)

      Eri Yamamoto, Naoto Tomita, Seiji Sakata, Naoko Tsuyama, Kengo Takeuchi, Yuki Nakajima, Kazuho Miyashita, Takayoshi Tachibana, Hirotaka Takasaki, Masatsugu Tanaka, Chizuko Hashimoto, Hideyuki Koharazawa, Katsumichi Fujimaki, Jun Taguchi, Hiroshi Harano, Shigeki Motomura and Yoshiaki Ishigatsubo

      Version of Record online: 27 NOV 2013 | DOI: 10.1111/cas.12288

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      The MIB-1 labeling index of 10% at diagnosis of FL is a useful cut-off point which predicts the PFS and OS. The multivariate analysis also show the independent significances with PFS and OS, respectively.

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      HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway (pages 1675–1682)

      Xiao-Song Ge, Hua-Juan Ma, Xiao-Hui Zheng, Hong-Lian Ruan, Xiao-Yu Liao, Wen-Qiong Xue, Yuan-Bin Chen, Ying Zhang and Wei-Hua Jia

      Version of Record online: 29 OCT 2013 | DOI: 10.1111/cas.12296

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      HOTAIR, a long non coding RNA, has been linked to the progression of several types of human cancer. In this study, we found that HOTAIR was not only significantly up-regulated in tumor tissues, but also significantly associated with poor clinical outcome in patients with esophageal squamous cell carcinoma (ESCC). ESCC cells with HOTAIR overexpression displayed aberrant activated WNT signaling pathway by inhibiting the expression of WNT-inhibitor factor 1, thereby promote the migration and invasion of ESCC cells. On the contrary, silencing of HOTAIR in ESCC cells led to decreased migration and invasion ability. Together, these results suggest that HOTAIR overexpression may serve as a novel prognostic biomarker and potential therapeutic target for the treatment of human ESCC.

    17. DRUG DISCOVERY AND DELIVERY

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      Nucleoside analog inhibits microRNA-214 through targeting heat-shock factor 1 in human epithelial ovarian cancer (pages 1683–1689)

      Yi-Fei Chen, Zhangli Dong, Yi Xia, Jingjie Tang, Ling Peng, Shuying Wang and Dongmei Lai

      Version of Record online: 22 OCT 2013 | DOI: 10.1111/cas.12277

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      Therapeutic role of EF24 targeting glucose transporter 1-mediated metabolism and metastasis in ovarian cancer cells (pages 1690–1696)

      Dandan Zhang, Yan Wang, Lina Dong, Yangang Huang, Jing Yuan, Wei Ben, Yang Yang, Ning Ning, Meisong Lu and Yongmei Guan

      Version of Record online: 12 NOV 2013 | DOI: 10.1111/cas.12293

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      We report in this study the inhibition effect of EF24 against the energy metabolism in ovarian cancer cells and tumors through the down-regulation of Glut1 expression. This effect may further lead to the inhibition of cell migration, invasion and tumor metastasis. Therefore, EF24 is likely a possible candidate for anti-metastasis therapeutic applications for ovarian cancer.

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      Small compound bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells (pages 1697–1704)

      Jing-Lei Liu, Guang-Zhi Zeng, Xiao-Li Liu, Yong-Qiang Liu, Zhong-Guo Hu, Ying Liu, Ning-Hua Tan and Guang-Biao Zhou

      Version of Record online: 8 NOV 2013 | DOI: 10.1111/cas.12295

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      A natural compound bigelovin arrests cell cycle at S phase by triggering proteolysis of oncoprotein E2F1, which is overexpressed in multiple myeloma cells.

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      In vivo delivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer (pages 1705–1710)

      Takahiro Koyanagi, Yasuhiro Suzuki, Yasushi Saga, Shizuo Machida, Yuji Takei, Hiroyuki Fujiwara, Mitsuaki Suzuki and Yasufumi Sato

      Version of Record online: 8 NOV 2013 | DOI: 10.1111/cas.12297

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      Administration of siRNA targeting a novel angiogenesis stimulator, vasohibin-2, with atelocollagen biomaterial retarded ovarian tumor growth through decrease of angiogenesis and acceleration of vascular normalization. These results demonstrated the effectiveness of molecular targeting of vasohibin-2 in ovarian cancer.

    21. EPIDEMIOLOGY AND PREVENTION

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      Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis (pages 1711–1717)

      Shugo Suzuki, Kazuhide Shiraga, Shinya Sato, Wanisa Punfa, Aya Naiki-Ito, Yoriko Yamashita, Tomoyuki Shirai and Satoru Takahashi

      Version of Record online: 28 OCT 2013 | DOI: 10.1111/cas.12292

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      Apocynin, a NADPH oxidase inhibitor, suppressed prostate carcinogenesis in TRAP model with reduction of reactive oxygen species (ROS) generation and cell proliferation in vivo. it also inhibited ROS production and blocked cell growth by inducing G0/G1 arrest with down-regulation of clusterin and cyclin D1 in LNCaP cells. These data suggest that apocynin possesses a chemopreventive potential for prostate cancer.

    22. PATHOLOGY

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      Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion (pages 1718–1725)

      Yuichiro Nakashima, Keiji Yoshinaga, Hiroyuki Kitao, Koji Ando, Yasue Kimura, Hiroshi Saeki, Eiji Oki, Masaru Morita, Yoshihiro Kakeji, Minako Hirahashi, Yoshinao Oda and Yoshihiko Maehara

      Version of Record online: 22 OCT 2013 | DOI: 10.1111/cas.12286

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      We focused on the expression of podoplanin in esophageal squamous cell carcinoma and inestigated the correlation of podoplanin and epithelial-mesenchymal transition. Podoplanin was significantly associated with and likely contibutes to the invasion of esophageal squamous cell caricinoma in absence of epithelial mesenchymal transition.

  6. REPORT

    1. Top of page
    2. COVER IMAGE
    3. PRELIMINARY PAGE
    4. IN THIS ISSUE
    5. REVIEW ARTICLE
    6. ORIGINAL ARTICLES
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