UGT1A1*6, 1A7*3, and 1A9*22 genotypes predict severe neutropenia in FOLFIRI-treated metastatic colorectal cancer in two prospective studies in Japan (pages 1662–1669)
Shoichi Hazama, Hideyuki Mishima, Ryouichi Tsunedomi, Yusuke Okuyama, Takeshi Kato, Ken-ichi Takahashi, Hiroshi Nozawa, Hideaki Ando, Michiya Kobayashi, Hiroyoshi Takemoto, Naoki Nagata, Shinsuke Kanekiyo, Yuka Inoue, Yoshihiko Hamamoto, Yusuke Fujita, Yuji Hinoda, Naoko Okayama, Koji Oba, Jun-ichi Sakamoto and Masaaki Oka
Version of Record online: 27 OCT 2013 | DOI: 10.1111/cas.12283
The toxicities were significantly more frequent in patients with UGT1A1*6, UGT1A7 (387G), and UGT1A9*22 reference alleles (T9). Six out of 7 patients who were homozygous for UGT1A1*28 or *6 experienced severe hematological toxicity despite the fact that their response rate was not impaired (42.9%).