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Cancer Science

Cover image for Vol. 105 Issue 2

February 2014

Volume 105, Issue 2

Pages February cover–February cover, i–iii, 143–243

  1. COVER IMAGE

    1. Top of page
    2. COVER IMAGE
    3. ISSUE INFORMATION
    4. IN THIS ISSUE
    5. REVIEW ARTICLE
    6. ORIGINAL ARTICLES
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      Roles of miR-148a in gastric cancer invasion by regulating MMP7 expression. MiR-148a expression in gastric cancer tissue detected by in situ hybridization. See also Sakamoto, N., et al. (pages 236–243 of this issue). (page February cover)

      Naoya Sakamoto, Yutaka Naito, Naohide Oue, Kazuhiro Sentani, Naohiro Uraoka, Htoo Zarni Oo, Kazuyoshi Yanagihara, Kazuhiko Aoyagi, Hiroki Sasaki and Wataru Yasui

      Article first published online: 10 FEB 2014 | DOI: 10.1111/cas.12344

  2. ISSUE INFORMATION

    1. Top of page
    2. COVER IMAGE
    3. ISSUE INFORMATION
    4. IN THIS ISSUE
    5. REVIEW ARTICLE
    6. ORIGINAL ARTICLES
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      Issue Information (pages i–ii)

      Article first published online: 10 FEB 2014 | DOI: 10.1111/cas.12255

  3. IN THIS ISSUE

    1. Top of page
    2. COVER IMAGE
    3. ISSUE INFORMATION
    4. IN THIS ISSUE
    5. REVIEW ARTICLE
    6. ORIGINAL ARTICLES
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      In This Issue (page iii)

      Article first published online: 16 JAN 2014 | DOI: 10.1111/cas.12345

  4. REVIEW ARTICLE

    1. Top of page
    2. COVER IMAGE
    3. ISSUE INFORMATION
    4. IN THIS ISSUE
    5. REVIEW ARTICLE
    6. ORIGINAL ARTICLES
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      Gist of Dr. Katsusaburo Yamagiwa's papers entitled “Experimental study on the pathogenesis of epithelial tumors” (I to VI reports) (pages 143–149)

      Hirota Fujiki

      Article first published online: 17 JAN 2014 | DOI: 10.1111/cas.12333

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      Drs. Yamagiwa and Ichikawa first published a comprehensive paper entitled “Experimental study on the pathogenesis of epithelial tumors” in 1915 in German. The essentials of their six reports under the same title have been translated into English as a short review. Scientists' comments on Yamagiwa's contribution are attached by way of introduction.

  5. ORIGINAL ARTICLES

    1. Top of page
    2. COVER IMAGE
    3. ISSUE INFORMATION
    4. IN THIS ISSUE
    5. REVIEW ARTICLE
    6. ORIGINAL ARTICLES
    1. BASIC AND CLINICAL IMMUNOLOGY

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      Role of plasmacytoid dendritic cells and inducible costimulator-positive regulatory T cells in the immunosuppression microenvironment of gastric cancer (pages 150–158)

      Xiao-Mei Huang, Xiao-Sun Liu, Xian-Ke Lin, Hang Yu, Jian-Yi Sun, Xiao-Kun Liu, Chao Chen, Hai-Long Jin, Ge-Er Zhang, Xiao-Xiao Shi, Qing Zhang and Ji-Ren Yu

      Article first published online: 4 JAN 2014 | DOI: 10.1111/cas.12327

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      We found that numbers of pDCs, Tregs and ICOS+ Tregs in peripheral blood were increased in GC patients compared with healthy donors. In tissue, Tregs and ICOS+ Tregs were found distributing mainly in carcinoma tissue, while pDCs mainly in peritumor tissue. Both pDCs and ICOS+ Tregs participate in the immunosuppression microenviroment of gastric cancer together.

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      Suppression of Tregs by anti-glucocorticoid induced TNF receptor antibody enhances the antitumor immunity of interferon-α gene therapy for pancreatic cancer (pages 159–167)

      Kouichirou Aida, Reina Miyakawa, Koji Suzuki, Kenta Narumi, Takeshi Udagawa, Yuki Yamamoto, Tatsuya Chikaraishi, Teruhiko Yoshida and Kazunori Aoki

      Article first published online: 4 JAN 2014 | DOI: 10.1111/cas.12332

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      The combination of GITR mAb and IFN-α gene therapy could be a promising therapeutic strategy for pancreatic cancer.

    3. CELL, MOLECULAR, AND STEM CELL BIOLOGY

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      Amino-terminal fragments of laminin γ2 chain retract vascular endothelial cells and increase vascular permeability (pages 168–175)

      Hiroki Sato, Jun Oyanagi, Eriko Komiya, Takashi Ogawa, Shouichi Higashi and Kaoru Miyazaki

      Article first published online: 7 JAN 2014 | DOI: 10.1111/cas.12323

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      An N-terminal fragment of the laminin gamma2 chain retracts vascular endothelial cells by inducing delocalization of VE-cadherin.

    4. CLINICAL RESEARCH

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      Macrophage inhibitory factor 1 acts as a potential biomarker in patients with esophageal squamous cell carcinoma and is a target for antibody-based therapy (pages 176–185)

      Xiao-Bing Wang, Xing-Ran Jiang, Xi-Ying Yu, Lin Wang, Shun He, Fei-Yue Feng, Li-Ping Guo, Wei Jiang and Shih-Hsin Lu

      Article first published online: 2 JAN 2014 | DOI: 10.1111/cas.12331

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      Serum MIC1 may serve as a diagnostic marker and an independent prognostic factor for ESCC. Additionally,monitoring of serum MIC1 after surgery is useful in evaluation of early recurrence. Notably, this study highlights that the over-expression of MIC1 was associated with lymph node metastasis and MIC1 can act as a therapeutic target for antibody-based therapy in the treatment of ESCC.

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      Apurinic/apyrimidinic endonuclease 1 induced upregulation of fibroblast growth factor 2 and its receptor 3 induces angiogenesis in human osteosarcoma cells (pages 186–194)

      Tao Ren, Yi Qing, Nan Dai, Mengxia Li, Chengyuan Qian, Yuxin Yang, Yi Cheng, Zheng Li, Shiheng Zhang, Zhaoyang Zhong and Dong Wang

      Article first published online: 27 JAN 2014 | DOI: 10.1111/cas.12334

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      APE1-siRNA markedly inhibited tumor angiogenesis by down-regulating FGF2/FGFR3 in vitro and in vivo. Therefore, the APE1-FGF2/FGFR3 pathway identified in this study may be a valuable molecular target for osteosarcoma therapy.

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      Bortezomib therapy-related lung disease in Japanese patients with multiple myeloma: Incidence, mortality and clinical characterization (pages 195–201)

      Kazutake Yoshizawa, Harumi Y. Mukai, Michiko Miyazawa, Makiko Miyao, Yoshimasa Ogawa, Kazuma Ohyashiki, Takao Katoh, Masahiko Kusumoto, Akihiko Gemma, Fumikazu Sakai, Yukihiko Sugiyama, Kiyohiko Hatake, Yuh Fukuda and Shoji Kudoh

      Article first published online: 21 JAN 2014 | DOI: 10.1111/cas.12335

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      Bortezomib therapy-related lung disease in Japanese patients with multiple myeloma: Incidence, mortality, and clinical characterization (radiographic pattern).

    7. DRUG DISCOVERY AND DELIVERY

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      Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines (pages 202–210)

      Tomomitsu Nasuno, Sachiyo Mimaki, Makito Okamoto, Hiroyasu Esumi and Katsuya Tsuchihara

      Article first published online: 5 DEC 2013 | DOI: 10.1111/cas.12322

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      There is a demand for effective molecular target drugs for esophageal cancer that combine an improved therapeutic efficacy with fewer adverse effects. Esophageal squamous cell carcinoma cell lines were screened with recently developed PARP inhibitors and a specific cell line, TE-6 exhibited better sensitivity.

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      Enhanced susceptibility of B lymphoma cells to measles virus by Epstein–Barr virus type III latency that upregulates CD150/signaling lymphocytic activation molecule (pages 211–218)

      Satoshi Takeda, Daiki Kanbayashi, Takako Kurata, Hironori Yoshiyama and Jun Komano

      Article first published online: 12 JAN 2014 | DOI: 10.1111/cas.12324

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      The type III Epstein-Barr virus (EBV) latency in B lymphoma cells augments the cytolytic activity of measles virus. This is attributed to the up-regulation of CD150 by EBV-encoded oncoprotein LMP1.

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      N1-guanyl-1,7-diaminoheptane sensitizes bladder cancer cells to doxorubicin by preventing epithelial–mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2 activation (pages 219–227)

      Jinsong Yang, Haogang Yu, Mo Shen, Wei Wei, Lihong Xia and Peng Zhao

      Article first published online: 7 JAN 2014 | DOI: 10.1111/cas.12328

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      Doxorubicin-induced EMT reduced the chemotherapeutic effect of doxorubicin treatment in bladder cancer cells. GC7, which inhibited activity of eIF5A2, sensitized bladder cancer cells to doxorubicin via preventing EMT. Combined treatment of GC7 and doxorubicin provides a new insight to clinic bladder cancer therapy.

    10. PATHOLOGY

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      MicroRNA-143 regulates collagen type III expression in stromal fibroblasts of scirrhous type gastric cancer (pages 228–235)

      Yutaka Naito, Naoya Sakamoto, Naohide Oue, Masakazu Yashiro, Kazuhiro Sentani, Kazuyoshi Yanagihara, Kosei Hirakawa and Wataru Yasui

      Article first published online: 8 JAN 2014 | DOI: 10.1111/cas.12329

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      MicroRNA-143 regulates the collagen type III expression through activation of transforming growth factor-β/SMAD pathway in stromal fibroblasts of scirrhous type gastric cancer.

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      MicroRNA-148a is downregulated in gastric cancer, targets MMP7, and indicates tumor invasiveness and poor prognosis (pages 236–243)

      Naoya Sakamoto, Yutaka Naito, Naohide Oue, Kazuhiro Sentani, Naohiro Uraoka, Htoo Zarni Oo, Kazuyoshi Yanagihara, Kazuhiko Aoyagi, Hiroki Sasaki and Wataru Yasui

      Article first published online: 6 JAN 2014 | DOI: 10.1111/cas.12330

      Thumbnail image of graphical abstract

      miR-148a expression was significantly downregulated in gastric cancer, and its downregulation was significantly correlated with an worse clinico-pathologic characters. MMP7 was found to be a direct and functional target of miR-148a, participating in cell invasion.

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