Characterization of common marmoset dysgerminoma-like tumor induced by the lentiviral expression of reprogramming factors (pages 402–408)
Saori Yamaguchi, Tomotoshi Marumoto, Takenobu Nii, Hirotaka Kawano, Jiyuan Liao, Yoko Nagai, Michiyo Okada, Atsushi Takahashi, Hiroyuki Inoue, Erika Sasaki, Hiroshi Fujii, Shinji Okano, Hayao Ebise, Tetsuya Sato, Mikita Suyama, Hideyuki Okano, Yoshie Miura and Kenzaburo Tani
Version of Record online: 5 APR 2014 | DOI: 10.1111/cas.12367
Reprogramming factors for iPSC generation can be oncogenic, and thus reprogramming factor transduced cells might have tumorigenic potential. Here we characterized common marmoset dysgerminoma like tumor, CM DGs, generated by the lentivirally transduced reprogramming factors into fibroblasts. The growth of CM DGs was dependent on c-MYC expression and bFGF signaling. Moreover CM DGs were highly sensitive to DNA damaging agents, irradiation and FGFR inhibitors. Therefore irradiation, DNA damaging agents and FGFR inhibitors might be effective for controlling reprogramming factor related tumors that may be found in patients treated with iPSC-based medicine.