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Cancer Science

Cover image for Vol. 105 Issue 4

April 2014

Volume 105, Issue 4

Pages April cover–April cover, i–iii, 363–498

  1. COVER IMAGE

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      ECT2 serves as a new biomarker for early-stage lung adenocarcinoma. A FISH image for a tumor showing high ECT2 amplification. Red signal shows the ECT2 gene, and green signal shows chromosome 3 enumeration. (page April cover)

      Yoshihiko Murata, Yuko Minami, Reika Iwakawa, Jun Yokota, Shingo Usui, Koji Tsuta, Kouya Shiraishi, Shingo Sakashita, Kaishi Satomi, Tatsuo Iijima and Masayuki Noguchi

      Version of Record online: 11 APR 2014 | DOI: 10.1111/cas.12384

  2. ISSUE INFORMATION

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      Issue Information (pages i–ii)

      Version of Record online: 11 APR 2014 | DOI: 10.1111/cas.12257

  3. IN THIS ISSUE

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    4. IN THIS ISSUE
    5. REVIEW ARTICLES
    6. ORIGINAL ARTICLES
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  4. REVIEW ARTICLES

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      Epigenetic dysregulation in glioma (pages 363–369)

      Yutaka Kondo, Keisuke Katsushima, Fumiharu Ohka, Atsushi Natsume and Keiko Shinjo

      Version of Record online: 24 MAR 2014 | DOI: 10.1111/cas.12379

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      In this review, we focus on the recent advancements in epigenetic research with respect to gliomas, consider how epigenetic mechanisms dynamically regulate tumor cells, including the cancer stem cell population, and discuss perspectives and challenges for glioma treatment in the near future.

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      Targeting DNA damage response in cancer therapy (pages 370–388)

      Noriko Hosoya and Kiyoshi Miyagawa

      Version of Record online: 21 MAR 2014 | DOI: 10.1111/cas.12366

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      This review explains various approaches for taking advantage of the cancer-specific properties of the DNA damage response in cancer therapy. It includes the mechanism of the DNA damage response, aberrations of DNA damage responses in cancers, and the results of the preclinical and clinical studies on inhibitors of DNA damage response pathways.

  5. ORIGINAL ARTICLES

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    1. BASIC AND CLINICAL IMMUNOLOGY

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      Heat shock protein DNAJB8 is a novel target for immunotherapy of colon cancer-initiating cells (pages 389–395)

      Rena Morita, Satoshi Nishizawa, Toshihiko Torigoe, Akari Takahashi, Yasuaki Tamura, Tomohide Tsukahara, Takayuki Kanaseki, Alice Sokolovskaya, Vitaly Kochin, Toru Kondo, Satoshi Hashino, Masahiro Asaka, Isao Hara, Yoshihiko Hirohashi and Noriyuki Sato

      Version of Record online: 24 FEB 2014 | DOI: 10.1111/cas.12362

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      A novel colon cancer-initiating antigen, DNAJB8 has role in the maintenance of colon cancer-initiating cells, and can be a target of CTLs.

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      Identification of anti-CD98 antibody mimotopes for inducing antibodies with antitumor activity by mimotope immunization (pages 396–401)

      Misa Saito, Masahiro Kondo, Motohiro Ohshima, Kazuki Deguchi, Hideki Hayashi, Kazuyuki Inoue, Daiki Tsuji, Takashi Masuko and Kunihiko Itoh

      Version of Record online: 17 MAR 2014 | DOI: 10.1111/cas.12365

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      Mimotope immunization and phage display selection provide antibody reactive with native tumor antigen.

    3. CARCINOGENESIS

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      Characterization of common marmoset dysgerminoma-like tumor induced by the lentiviral expression of reprogramming factors (pages 402–408)

      Saori Yamaguchi, Tomotoshi Marumoto, Takenobu Nii, Hirotaka Kawano, Jiyuan Liao, Yoko Nagai, Michiyo Okada, Atsushi Takahashi, Hiroyuki Inoue, Erika Sasaki, Hiroshi Fujii, Shinji Okano, Hayao Ebise, Tetsuya Sato, Mikita Suyama, Hideyuki Okano, Yoshie Miura and Kenzaburo Tani

      Version of Record online: 5 APR 2014 | DOI: 10.1111/cas.12367

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      Reprogramming factors for iPSC generation can be oncogenic, and thus reprogramming factor transduced cells might have tumorigenic potential. Here we characterized common marmoset dysgerminoma like tumor, CM DGs, generated by the lentivirally transduced reprogramming factors into fibroblasts. The growth of CM DGs was dependent on c-MYC expression and bFGF signaling. Moreover CM DGs were highly sensitive to DNA damaging agents, irradiation and FGFR inhibitors. Therefore irradiation, DNA damaging agents and FGFR inhibitors might be effective for controlling reprogramming factor related tumors that may be found in patients treated with iPSC-based medicine.

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      Human papillomavirus and p53 mutations in head and neck squamous cell carcinoma among Japanese population (pages 409–417)

      Hiromi Maruyama, Toshimichi Yasui, Tomoko Ishikawa-Fujiwara, Eiichi Morii, Yoshifumi Yamamoto, Tadashi Yoshii, Yukinori Takenaka, Susumu Nakahara, Takeshi Todo, Tadashi Hongyo and Hidenori Inohara

      Version of Record online: 30 MAR 2014 | DOI: 10.1111/cas.12369

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      Head and neck squamous cell carcinoma (HNSCC) is etiologically classified into virus-related and virus-unrelated subgroups. In virus-related HNSCC p53 mutations are uncommon with the absence of a disruptive mutation, whereas in virus-unrelated HNSCC p53 mutations are common, and disruptive mutagenesis of p53 is closely related with oropharyngeal and hypopharyngeal carcinoma.

    5. CELL, MOLECULAR, AND STEM CELL BIOLOGY

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      Context-dependent activation of Wnt signaling by tumor suppressor RUNX3 in gastric cancer cells (pages 418–424)

      Xiaoli Ju, Tomo-o Ishikawa, Kazuhito Naka, Kosei Ito, Yoshiaki Ito and Masanobu Oshima

      Version of Record online: 18 FEB 2014 | DOI: 10.1111/cas.12356

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      Approximately 73% of RUNX3 positive gastric cancer cells are positive for beta-catenin, indicating that Wnt signaling is activated by RUNX3 in KatoIII cells.

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      MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells (pages 425–430)

      Hiroaki Sakai, Ai Sato, Yuki Aihara, Yoshinori Ikarashi, Yutaka Midorikawa, Michael Kracht, Hitoshi Nakagama and Koji Okamoto

      Version of Record online: 24 MAR 2014 | DOI: 10.1111/cas.12380

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      MKK7 is a novel target of miR-493 and plays a major role in miR-493-mediated suppression of liver metastasis of colon cancer. These findings are clinically relevant, because immunohistochemical examination in human primary colon tumors revealed that the occurrence of liver metastasis is associated with elevated levels of MKK7.

    7. CLINICAL RESEARCH

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      Increased risk of cancer in patients with early-onset cataracts: A nationwide population-based study (pages 431–436)

      Chun Chi Chiang, Cheng-Li Lin, Chiao-Ling Peng, Fung-Chang Sung and Yi-Yu Tsai

      Version of Record online: 11 MAR 2014 | DOI: 10.1111/cas.12360

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      Usually cataract is considered as an isolated ophthalmic disease. This manuscript provides an interesting aspect of relationship between early onset cataract and cancer. We analyzed varied cancers and the possible associations.

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      Association between BACH2 expression and clinical prognosis in diffuse large B-cell lymphoma (pages 437–444)

      Satoshi Ichikawa, Noriko Fukuhara, Hiroki Katsushima, Taro Takahashi, Joji Yamamoto, Hisayuki Yokoyama, Osamu Sasaki, Osamu Fukuhara, Jun Nomura, Kenichi Ishizawa, Ryo Ichinohasama, Akihiko Muto, Kazuhiko Igarashi and Hideo Harigae

      Version of Record online: 8 MAR 2014 | DOI: 10.1111/cas.12361

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      BACH2 expression level is a promising predictor of prognosis for diffuse large B-cell lymphoma. That is, high BACH2 expression level could be associated with worse prognosis.

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      Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress (pages 445–454)

      Jun-gang Zhang, De-fei Hong, Cheng-wu Zhang, Xiao-dong Sun, Zhi-fei Wang, Ying Shi, Jun-wei Liu, Guo-liang Shen, Yuan-biao Zhang, Jian Cheng, Chun-you Wang and Gang Zhao

      Version of Record online: 17 MAR 2014 | DOI: 10.1111/cas.12364

      We explore the effect of SIRT1 in the regulation of adaptive response in chemotherapy-induced stress which is involved in chemoresistance to pancreatic ductal adenocarcinoma (PDAC). In this article, we imply that blocking SIRT1 activity with targeting drug might be a novel treatment to enhance the chemosensitivity of PDAC, which lay a foundation of further study.

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      Japanese phase I study of GC33, a humanized antibody against glypican-3 for advanced hepatocellular carcinoma (pages 455–462)

      Masafumi Ikeda, Shinichi Ohkawa, Takuji Okusaka, Shuichi Mitsunaga, Satoshi Kobayashi, Chigusa Morizane, Ikue Suzuki, Shunsuke Yamamoto and Junji Furuse

      Version of Record online: 25 MAR 2014 | DOI: 10.1111/cas.12368

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      GC33 administered at up to 20 mg/kg weekly was well tolerated in Japanese patients with advanced hepatocellular carcinoma. Seven of the 13 patients showed stable disease, the other six showed progressive disease. Furthermore, three patients showed long stable disease of more than 5 months.

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      Effect of microRNA-210 on prognosis and response to chemotherapeutic drugs in pediatric acute lymphoblastic leukemia (pages 463–472)

      Yanyan Mei, Chao Gao, Kailing Wang, Lei Cui, Weijing Li, Xiaoxi Zhao, Feifei Liu, Minyuan Wu, Guoren Deng, Wei Ding, Hongti Jia and Zhigang Li

      Version of Record online: 30 MAR 2014 | DOI: 10.1111/cas.12370

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      In the current study, we first demonstrate the clinical significance of microRNA-210 and its effects on the response of leukemic cells to chemotherapeutic drugs in pediatric acute lymphoblastic leukemia, which to our knowledge has not been reported before.

    12. DRUG DISCOVERY AND DELIVERY

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      2-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinase (pages 473–480)

      Shan Kuang, Chunting Qi, Jiawei Liu, Xiaoxiao Sun, Qing Zhang, Zhenhua Sima, Jingli Liu, Wuguo Li and Qiang Yu

      Version of Record online: 3 MAR 2014 | DOI: 10.1111/cas.12359

      Natural compound from Polygonum cuspidatum as a promising anticancer drug candidate by inhibiting STAT3 and NF-κB signalling. A novel dual kinase inhibitor of JAK2 and IKKβ. May form adducts with the thiols of the cysteins in the JAK2 and IKKβ proteins.

    13. GENETICS, GENOMICS AND PROTEOMICS

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      Array-comparative genomic hybridization profiling of immunohistochemical subgroups of diffuse large B-cell lymphoma shows distinct genomic alterations (pages 481–489)

      Ying Guo, Ichiro Takeuchi, Sivasundaram Karnan, Tomoko Miyata, Koichi Ohshima and Masao Seto

      Version of Record online: 24 MAR 2014 | DOI: 10.1111/cas.12378

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      Characteristic genomic differences were found between GCB and non-GCB DLBCL from the array data. We also found completely different mutations in BCL6+ and BCL6- non-GCB type DLBCL.

    14. PATHOLOGY

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      ECT2 amplification and overexpression as a new prognostic biomarker for early-stage lung adenocarcinoma (pages 490–497)

      Yoshihiko Murata, Yuko Minami, Reika Iwakawa, Jun Yokota, Shingo Usui, Koji Tsuta, Kouya Shiraishi, Shingo Sakashita, Kaishi Satomi, Tatsuo Iijima and Masayuki Noguchi

      Version of Record online: 18 MAR 2014 | DOI: 10.1111/cas.12363

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      Abnormality of the ECT2 gene occurs at a relatively early stage of lung adenocarcinogenesis and would be applicable as a new biomarker for prognostication of patients with lung adenocarcinoma.

  6. Correction

    1. Top of page
    2. COVER IMAGE
    3. ISSUE INFORMATION
    4. IN THIS ISSUE
    5. REVIEW ARTICLES
    6. ORIGINAL ARTICLES
    7. Correction
    1. You have full text access to this OnlineOpen article

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