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Cancer Science

Cover image for Vol. 105 Issue 6

June 2014

Volume 105, Issue 6

Pages June cover–June cover, i–iii, 623–748

  1. COVER IMAGE

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    3. ISSUE INFORMATION
    4. IN THIS ISSUE
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    6. ORIGINAL ARTICLES
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      Low CD274 expression increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma. Anti-CD274 staining of a clinical specimen from a patient with cholangiocarcinoma by surgical resection (page June cover)

      Keiichi Tamai, Mao Nakamura, Masamichi Mizuma, Mai Mochizuki, Misa Yokoyama, Hiroyuki Endo, Kazunori Yamaguchi, Takayuki Nakagawa, Masaaki Shiina, Michiaki Unno, Koji Muramoto, Ikuro Sato, Kennichi Satoh, Kazuo Sugamura and Nobuyuki Tanaka

      Version of Record online: 4 JUN 2014 | DOI: 10.1111/cas.12423

  2. ISSUE INFORMATION

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      Issue Information (pages i–ii)

      Version of Record online: 4 JUN 2014 | DOI: 10.1111/cas.12259

  3. IN THIS ISSUE

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      In This Issue (page iii)

      Version of Record online: 14 MAY 2014 | DOI: 10.1111/cas.12424

  4. REVIEW ARTICLE

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      Disease-specific mutations in mature lymphoid neoplasms: Recent advances (pages 623–629)

      Mamiko Sakata-Yanagimoto, Terukazu Enami, Yasuhisa Yokoyama and Shigeru Chiba

      Version of Record online: 12 MAY 2014 | DOI: 10.1111/cas.12408

      In this review, we focused on the disease-specific gene mutations in mature lymphoid neoplasm (MLNs), which were discovered by us and others, using recent massive sequencing technologies. We further discussed the possible application of these mutations in diagnosis of MLN subtypes and as molecular targets of therapies.

  5. ORIGINAL ARTICLES

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    1. CARCINOGENESIS

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      Capn4 is a marker of poor clinical outcomes and promotes nasopharyngeal carcinoma metastasis via nuclear factor-κB-induced matrix metalloproteinase 2 expression (pages 630–638)

      Pei-Chan Zheng, Xiong Chen, Hong-Wu Zhu, Wei Zheng, Li-Hua Mao, Cheng Lin, Jing-Nan Liu and Ming Zheng

      Version of Record online: 20 MAY 2014 | DOI: 10.1111/cas.12416

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      Capn4 is a marker of poor clinical outcomes that promotes nasopharyngeal carcinoma metastasis via NF-kB induced MMP2 expression.

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      Peripheral blood mitochondrial DNA content, A10398G polymorphism, and risk of breast cancer in a Han Chinese population (pages 639–645)

      Huangang Jiang, Hong Zhao, Hui Xu, Liu Hu, Wenbo Wang, Yuehua Wei, You Wang, Xiaohong Peng and Fuxiang Zhou

      Version of Record online: 30 MAY 2014 | DOI: 10.1111/cas.12412

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      Our finding suggested that the peripheral blood mtDNA content might be potentially used as a tool to estimate risk of breast cancer for selected Chinese women. The risk of breast cancer was associated with decreased mtDNA content in premenstrual women. On the contrary, increased mtDNA content is associated with breast cancer risk in aged and postmenopausal women.

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      Impact of epidermal growth factor single-nucleotide polymorphism on recurrence of hepatocellular carcinoma after hepatectomy in patients with chronic hepatitis C virus infection (pages 646–650)

      Shohei Yoshiya, Yukiko Fujimoto, Yuki Bekki, Hideyuki Konishi, Yo-ichi Yamashita, Toru Ikegami, Tomoharu Yoshizumi, Ken Shirabe, Yoshinao Oda and Yoshihiko Maehara

      Version of Record online: 15 MAY 2014 | DOI: 10.1111/cas.12415

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      EGF *61 AA was associated with a lower risk of recurrence after curative hepatectomy for HCC in patients with hepatitis C virus infection than other genotypes. EGFR expression in cancer cells was not significantly associated with prognosis.

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      MGr1-Ag/37LRP induces cell adhesion-mediated drug resistance through FAK/PI3K and MAPK pathway in gastric cancer (pages 651–659)

      Li Sun, Lili Liu, Xiangqiang Liu, Yafang Wang, Mengbin Li, Liping Yao, Jianjun Yang, Genlin Ji, Changcun Guo, Yanglin Pan, Shuhui Liang, Biaoluo Wang, Jie Ding, Hongwei Zhang and Yongquan Shi

      Version of Record online: 12 MAY 2014 | DOI: 10.1111/cas.12414

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      In this study, our experimental results showed that gastric cancer MDR cell lines mediated CAM-DR via up-regulation of Bcl-2 by MGr1-Ag interaction with LN. Further study found that, as a receptor of ECM components, MGr1-Ag/37LRP may activate the downstream signal pathway PI3K/AKT and MAPK/ERK via the interaction with pFAK.

    5. CELL, MOLECULAR, AND STEM CELL BIOLOGY

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      LIM protein JUB promotes epithelial–mesenchymal transition in colorectal cancer (pages 660–666)

      Xing-Hua Liang, Guang-Xian Zhang, Yue-bin Zeng, Hai-Feng Yang, Wen-Hong Li, Qi-Long Liu, Yue-liang Tang, Wen-guang He, Yan-Nian Huang, Lei Zhang, Li-Na Yu and Xian-Cheng Zeng

      Version of Record online: 10 MAY 2014 | DOI: 10.1111/cas.12404

      Ajuba family proteins were reported to be transcription repressors regulating kinds of physiological process. However, roles of Ajuba family proteins in colorectal cancer (CRC) remain poorly studied. We found that JUB was highly upregulated in clinical specimens and CRC cell lines. JUB induced EMT and enhanced motility and invasiveness in CRC. Mechanistic studies revealed that JUB induces EMT via Snail and JUB is also required for Snail-induced EMT. These findings uncovered that the LIM protein JUB serves as an oncogene in CRC by promoting EMT. Thus this may provide a novel target for therapy of metastatic CRC.

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      Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma (pages 667–674)

      Keiichi Tamai, Mao Nakamura, Masamichi Mizuma, Mai Mochizuki, Misa Yokoyama, Hiroyuki Endo, Kazunori Yamaguchi, Takayuki Nakagawa, Masaaki Shiina, Michiaki Unno, Koji Muramoto, Ikuro Sato, Kennichi Satoh, Kazuo Sugamura and Nobuyuki Tanaka

      Version of Record online: 7 MAY 2014 | DOI: 10.1111/cas.12406

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      Novel function of CD274 involving in the negative regulation of CSC-related phenotypes in human cholangiocarcinoma.

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      Loss of B-cell translocation gene 2 expression in estrogen receptor-positive breast cancer predicts tamoxifen resistance (pages 675–682)

      Maiko Takahashi, Tetsu Hayashida, Hiroshi Okazaki, Kazuhiro Miyao, Hiromitsu Jinno and Yuko Kitagawa

      Version of Record online: 2 MAY 2014 | DOI: 10.1111/cas.12410

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      Tamoxifen treatment effectively inhibits tumor progression with BTG2 expression in mouse xenograft experiment.

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      Peroxisome proliferator-activated receptor γ agonist efatutazone impairs transforming growth factor β2-induced motility of epidermal growth factor receptor tyrosine kinase inhibitor-resistant lung cancer cells (pages 683–689)

      Masakuni Serizawa, Haruyasu Murakami, Masaru Watanabe, Toshiaki Takahashi, Nobuyuki Yamamoto and Yasuhiro Koh

      Version of Record online: 10 MAY 2014 | DOI: 10.1111/cas.12411

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      We previously reported that EGFR-TKI-resistant NSCLC cells acquire the enhanced motility via TGF-β2-induced activation of the TGF-β/Smad2 pathway. In this study, we revealed that efatutazone, a novel third-generation PPARγ agonist attenuated the enhanced motility of EGFR-TKI-resistant cells by downregulating TGF-β2 transcription regardless of the resistance mechanisms. Therefore, this study implies that efatutazone may serve as a potential therapeutic agent to prevent metastasis after developing acquired resistance to EGFR-TKIs regardless of the resistance mechanisms.

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      Stathmin1 regulates p27 expression, proliferation and drug resistance, resulting in poor clinical prognosis in cholangiocarcinoma (pages 690–696)

      Akira Watanabe, Hideki Suzuki, Takehiko Yokobori, Mariko Tsukagoshi, Bolag Altan, Norio Kubo, Shigemasa Suzuki, Kenichiro Araki, Satoshi Wada, Kenji Kashiwabara, Yasuo Hosouchi and Hiroyuki Kuwano

      Version of Record online: 26 MAY 2014 | DOI: 10.1111/cas.12417

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      We revealed that stathmin1 contributes to poor prognosis and cancer progression in EHCC and interact with p27 on cytoplasm of cholangiocarcinoma cells, and consequently the regulation of p27 by STMN1 could provide new insight for overcoming therapeutic target in EHCC.

    10. CLINICAL RESEARCH

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      Risk factors for hepatitis B virus reactivation after conformal radiotherapy in patients with hepatocellular carcinoma (pages 697–703)

      Wei Huang, Wei Zhang, Min Fan, Yanda Lu, Jian Zhang, Hongsheng Li and Baosheng Li

      Version of Record online: 20 APR 2014 | DOI: 10.1111/cas.12400

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      Hepatitis following systemic chemotherapy has been reported in 60%, which is mostly attributed to HBV reactivation. In recent years, 3D-CRT and IMRT are widely and increasingly used in HCC patients. However, whether HBV reactivation could be observed in HCC patients after radiotherapy and what are the risk factors for HBV reactivation are not clear. The study is an assessment of the occurrence condition and risk factors for HBV reactivation in HCC patients after precise radiotherapy.

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      Downregulation of DAB2IP results in cell proliferation and invasion and contributes to unfavorable outcomes in bladder cancer (pages 704–712)

      Yi-Jun Shen, Zhao-Lu Kong, Fang-Ning Wan, Hong-Kai Wang, Xiao-Jie Bian, Hua-Lei Gan, Chao-Fu Wang and Ding-Wei Ye

      Version of Record online: 8 MAY 2014 | DOI: 10.1111/cas.12407

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      Low expression of DAB2IP is associated with features of biologically aggressive bladder cancer. Down-regulation of DAB2IP results in cell proliferation, migration and invasion of bladder cancer in vitro. DAB2IP has an independent prognostic value in RC patients and may serve as a novel biomarker and potential therapeutic target for bladder cancer.

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      Anti-tumor effects of suberoylanilide hydroxamic acid on Epstein–Barr virus-associated T cell and natural killer cell lymphoma (pages 713–722)

      Mohammed N.A. Siddiquey, Hikaru Nakagawa, Seiko Iwata, Tetsuhiro Kanazawa, Michio Suzuki, Ken-Ichi Imadome, Shigeyoshi Fujiwara, Fumi Goshima, Takayuki Murata and Hiroshi Kimura

      Version of Record online: 12 MAY 2014 | DOI: 10.1111/cas.12418

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      SAHA inhibits tumor growth and metastasis of EBV-positive NK cell lymphoma. EBER-positive cells were detected by in situ hybridization in organ tissues of SAHA-treated or control mice.

    13. DRUG DISCOVERY AND DELIVERY

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      Lenvatinib in combination with golvatinib overcomes hepatocyte growth factor pathway-induced resistance to vascular endothelial growth factor receptor inhibitor (pages 723–730)

      Takayuki Nakagawa, Tomohiro Matsushima, Satoshi Kawano, Youya Nakazawa, Yu Kato, Yusuke Adachi, Takanori Abe, Taro Semba, Akira Yokoi, Junji Matsui, Akihiko Tsuruoka and Yasuhiro Funahashi

      Version of Record online: 27 APR 2014 | DOI: 10.1111/cas.12409

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      Several VEGFR inhibitors are approved for the treatment of tumor patient however, intrinsic or acquired resistance of tumor is coming serious problem. In this study we discovered that HGF from tumor cells confers resistance to tumor endothelial cells against VEGFR inhibitors and that combination therapy of VEGFR inhibitors with Met inhibitors may be effective for overcoming resistance to VEGFR inhibitors.

    14. EPIDEMIOLOGY AND PREVENTION

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      Genetic variants at 8q24 are associated with risk of esophageal squamous cell carcinoma in a Chinese population (pages 731–735)

      Ningbin Dai, Mingfeng Zheng, Cheng Wang, Yong Ji, Jiangbo Du, Chen Zhu, Yisha He, Meng Zhu, Xun Zhu, Min Sun, Juncheng Dai, Hongxia Ma, Jingyu Chen, Zhibin Hu, Haiyong Gu, Guangfu Jin and Hongbing Shen

      Version of Record online: 13 APR 2014 | DOI: 10.1111/cas.12399

      We evaluated the relationship of gastric cancer (GC) risk-related variants at 1q22, 3q13.3, 5p13.1 and 8q24 with the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese population with 2139 cases and 2273 controls. We found the T allele of rs2294008, an intronic variant of PSCA at 8q24 that was associated with an increased risk of GC, was inversely associated with a decreased risk of ESCC (OR = 0.90, 95 %CI: 0.81–0.99, P = 0.034).

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      Serum carotenoid levels and risk of lung cancer death in US adults (pages 736–743)

      Kyoung-bok Min and Jin-young Min

      Version of Record online: 6 MAY 2014 | DOI: 10.1111/cas.12405

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      High serum levels of alpha-carotene and beta-cryptoxanthin at baseline were significantly associated with a lower risk of lung cancer mortality after adjustment for potential covariates.The mortality risk of current smokers was significantly decreased to 46% (95% CI, 0.31–0.94) for alpha-carotene and 61% (95% CI, 0.19–0.80) for beta-cryptoxanthin, respectively. By contrast, no association was observed among never/former smokers at baseline.

  6. REPORT

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      Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone (pages 744–748)

      Mika Kato Kaneko, Xing Liu, Hiroharu Oki, Satoshi Ogasawara, Takuro Nakamura, Noriko Saidoh, Yuta Tsujimoto, Yuka Matsuyama, Akira Uruno, Masato Sugawara, Takashi Tsuchiya, Mitsunori Yamakawa, Masayuki Yamamoto, Michiaki Takagi and Yukinari Kato

      Version of Record online: 4 JUN 2014 | DOI: 10.1111/cas.12413

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      This is the first report to describe IDH mutations in giant cell tumor of bone (GCTB), and MsMab-1 can be anticipated for use in immunohistochemical determination of IDH1/2 mutation-bearing GCTB.

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