Computational Studies of Novel Chymase Inhibitors Against Cardiovascular and Allergic Diseases: Mechanism and Inhibition
Article first published online: 25 OCT 2012
© 2012 John Wiley & Sons A/S
Chemical Biology & Drug Design
Volume 80, Issue 6, pages 862–875, December 2012
How to Cite
Arooj, M., Thangapandian, S., John, S., Hwang, S., Park, J. K. and Lee, K. W. (2012), Computational Studies of Novel Chymase Inhibitors Against Cardiovascular and Allergic Diseases: Mechanism and Inhibition. Chemical Biology & Drug Design, 80: 862–875. doi: 10.1111/cbdd.12006
- Issue published online: 25 OCT 2012
- Article first published online: 25 OCT 2012
- Accepted manuscript online: 27 JUL 2012 04:34AM EST
- Received 3 April 2012, revised 30 May 2012 and accepted for publication 4 July 2012
Figure S1. Overall 3D structure of human chymase and the zoomed view that clearly shows the important catalytic residues.
Figure S2. Molecular docking validation results: overlay of the docked poses (gray) of inhibitors with their crystal structure conformation (green for 3N7O, pink for 3SON).
|CBDD_12006_sm_FigS1-S2.doc||1160K||Supporting info item|
|CBDD_12006_sm_FigS1.tif||4143K||Supporting info item|
|CBDD_12006_sm_FigS2.tif||1756K||Supporting info item|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.