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Prospects in the Total Synthesis of Protein Therapeutics


  • Justin M. Chalker

    1. Department of Chemistry and Biochemistry, The University of Tulsa, Keplinger Hall M245, 800 South Tucker Drive, Tulsa, OK 74104-9700, USA
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Corresponding author: Justin M. Chalker,


Protein therapeutics are gaining headway in the treatment and prevention of a variety of maladies. Critical to the success and growing use of biologic-level pharmaceuticals is the development of methods for their precise synthesis. This review highlights the emerging techniques for the total synthesis of proteins, with a special focus on the possibility of accessing therapeutic targets through chemoselective peptide ligations.