SEARCH

SEARCH BY CITATION

Figure S1. Raw data for the titration of 0.415 mM TC with 0.09 mm BSA at pH 7.4 and 25 °C, showing the calorimetric response as successive injections of the ligand are added to the sample cell (upper panels), and the corresponding integrated heat profile (lower panels).

Figure S2. Raw data for the titration of 0.415 mM RTC with 0.15 mm BSA at pH 7.4 and 25 °C, showing the calorimetric response as successive injections of the ligand are added to the sample cell (upper panels), and the corresponding integrated heat profile (lower panels).

Figure S3. ITC profile for the titration of 0.415 mM RTC to 0.15 mM BSA in the presence of (A) 0.01 M NaCl, (B) 0.05 M NaCl at pH 7.4 and 25 °C.

Figure S4. ITC profile for the titration of 0.415 mM RTC to 0.15 mM BSA in the presence of 0.02 M TBAB at pH 7.4 and 25 °C.

Figure S5. ITC profile for the titration of 0.415 mM RTC to 0.15 mM BSA in the presence of (A) 0.5 M sucrose, (B) 1.0 M sucrose at pH 7.4 and 25 °C.

Figure S6. ITC profile for the titration of 0.415 mM RTC to 0.15 mM BSA in the presence of 0.35 mM TX-100 at pH 7.4 and 25 °C.

Figure S7. (A) Intrinsic fluorescence emission spectra of BSA in the presence of increasing [RTC]/[BSA] molar ratio, (B) Plot of Fo/(FoF) against 1/[RTC] at pH 7.4.

Figure S8. Plot of F0/F (▲:TC, ■:RTC)and τ0/τ (●:TC, ▼:RTC) against quenching concentration.

Figure S9. Circular Dichroism (CD) spectra of BSA in the presence of RTC: (A) far-UV CD spectrum and (B) near-UV CD spectrum at different drug to protein molar ratios.

Figure S10. Intrinsic fluorescence emission spectra of BSA-warfarin complex in presence of increasing [RTC]/[BSA] molar ratios, (B) Intrinsic fluorescence emission spectra of BSA-RTC complex in presence of increasing [warfarin]/[BSA] molar ratios.

FilenameFormatSizeDescription
CBDD_12009_sm_FigS1-S10.doc2744KSupporting info item

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.